Fenofibrate and Metformin Fixed Combination vs Rosiglitazone - FAME ROSI

NCT ID: NCT00361868

Last Updated: 2008-06-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

88 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-06-30

Study Completion Date

2007-12-31

Brief Summary

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Under conditions of first-line drug treatment in antidiabetic drug naïve/drug free patients with type 2 diabetes mellitus and dyslipidemia, to show that :- the efficacy of a fixed combination (FC) of fenofibrate and metformin on glycemic control is not inferior to that of rosiglitazone and the efficacy of FC of fenofibrate and metformin on triglyceride control is superior to that of rosiglitazone.

Detailed Description

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Conditions

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Dyslipidemia Glucose Metabolism Disorder

Keywords

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Treatment of Dyslipidemia and of Type 2 Diabetes Mellitus

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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1

Group Type EXPERIMENTAL

fenofibrate (F) + metformin (M) hydrochloride fixed combination

Intervention Type DRUG

First period: F80mg/M500mg - per os - twice a day during 2 weeks and F80mg/M850mg - per os - twice a day during 10 weeks - Second period: F54mg/M850mg - per os - three times a day during 12 weeks

2

Group Type ACTIVE_COMPARATOR

Rosiglitazone

Intervention Type DRUG

First period: 4 mg - per os - daily during 12 weeks - Second period: 4 mg - per os - twice a day during 12 weeks

Interventions

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fenofibrate (F) + metformin (M) hydrochloride fixed combination

First period: F80mg/M500mg - per os - twice a day during 2 weeks and F80mg/M850mg - per os - twice a day during 10 weeks - Second period: F54mg/M850mg - per os - three times a day during 12 weeks

Intervention Type DRUG

Rosiglitazone

First period: 4 mg - per os - daily during 12 weeks - Second period: 4 mg - per os - twice a day during 12 weeks

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patient with Type 2 diabetes mellitus and dyslipidemia inadequately controlled with lifestyle modifications.

Exclusion Criteria

* Type 1 diabetes.
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Solvay Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Solvay Pharmaceuticals

Principal Investigators

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Global Clinical Director Solvay

Role: STUDY_DIRECTOR

Solvay Pharmaceuticals

Locations

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Site105

Pula, , Croatia

Site Status

Site102

Rijeka, , Croatia

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Site103

Split, , Croatia

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Site104

Varaždin, , Croatia

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Site100

Zagreb, , Croatia

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Site101

Zagreb, , Croatia

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Site 205

Jyväskylä, , Finland

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Site 206

Kokkola, , Finland

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Site 208

Laukaa, , Finland

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Site 207

Oulu, , Finland

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Site 303

Bassens, , France

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Site 307

Bordeaux, , France

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Site 305

Mûrs-Erigné, , France

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Site 302

Seysses, , France

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Site 304

Strasbourg, , France

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Site 301

Thouars, , France

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Site 306

Vihiers, , France

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Site 405

Berlin, , Germany

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Site 410

Borna, , Germany

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Site 403

Bretten, , Germany

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Site 402

Dresden, , Germany

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Site 404

Frankfurt, , Germany

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Site 400

Freiburg im Breisgau, , Germany

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Site 401

Hanover, , Germany

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Site 409

Ilvesheim, , Germany

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Site 411

Ilvesheim, , Germany

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Site 407

Leipzig, , Germany

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Site 406

Rodgau, , Germany

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Site 413

Rotenburg (Wümme), , Germany

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Site 408

Schwerin, , Germany

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Site 412

Villingen-Schwenningen, , Germany

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Site 509

Almere Stad, , Netherlands

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Site 502

Breda, , Netherlands

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Site 503

Eindhoven, , Netherlands

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Site 504

Groningen, , Netherlands

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Site 505

Leiden, , Netherlands

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Site 506

Nijmegen, , Netherlands

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Site 500

Rotterdam, , Netherlands

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Site 507

Velp, , Netherlands

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Site 508

Zoetermeer, , Netherlands

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Site 610

Bialystok, , Poland

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Site 606

Elblag, , Poland

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Site 608

Gdansk, , Poland

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Site 600

Lodz, , Poland

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Site 605

Otolinska, , Poland

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Site 604

Radom, , Poland

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Site 613

Starogard Gdański, , Poland

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Site 601

Warsaw, , Poland

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Site 607

Warsaw, , Poland

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Site 612

Warsaw, , Poland

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Site 602

Wroclaw, , Poland

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Site 603

Wroclaw, , Poland

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Site 704

Brasov, , Romania

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Site 701

Bucharest, , Romania

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Site 703

Bucharest, , Romania

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Site 700

Cluj-Napoca, , Romania

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Site 702

Iași, , Romania

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Site 705

Târgu Mureş, , Romania

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Site 807

Kharkiv, , Ukraine

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Site 811

Kharkiv, , Ukraine

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Site 812

Kharkiv, , Ukraine

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Site 800

Kiev, , Ukraine

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Site 803

Kiev, , Ukraine

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Site 808

Kiev, , Ukraine

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Site 809

Kiev, , Ukraine

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Site 810

Kiev, , Ukraine

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Site 813

Kiev, , Ukraine

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Site 805

Lviv, , Ukraine

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Site 804

Odesa, , Ukraine

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Site 802

Vinnitsa, , Ukraine

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Countries

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Croatia Finland France Germany Netherlands Poland Romania Ukraine

Other Identifiers

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2005-006060-63

Identifier Type: -

Identifier Source: secondary_id

C LF23-0121 05 01

Identifier Type: -

Identifier Source: org_study_id