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Oxytocin Effects on Cytokines and Endocrine Parameters After LPS Induced Systemic Inflammatory Effects in Healthy Volunteers

NCT ID: NCT00360048

Last Updated: 2007-12-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

10 participants

Study Classification

OBSERVATIONAL

Study Start Date

2006-08-31

Brief Summary

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The aim of this study is to determine if oxytocin administration is able to blunt LPS induced increase of cytokines (TNF-α) and if there is a change in the endocrine response after lipopolysaccharide administration in humans.

Detailed Description

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Conditions

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Sepsis

Keywords

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oxytocin tnf sepsis lps

Study Design

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Study Time Perspective

PROSPECTIVE

Interventions

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oxytocin

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Men aged 18 years or older with no disease history
* Written informed consent

Exclusion Criteria

* Receiving any medication
* Probands who suffer from infectious disease
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Medical University of Vienna

OTHER

Sponsor Role lead

Principal Investigators

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Martin Clodi, MD, Associate Professor

Role: PRINCIPAL_INVESTIGATOR

Medical University of Vienna

Locations

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Medical University of Vienna

Vienna, , Austria

Site Status

Countries

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Austria

References

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Vila G, Riedl M, Resl M, van der Lely AJ, Hofland LJ, Clodi M, Luger A. Systemic administration of oxytocin reduces basal and lipopolysaccharide-induced ghrelin levels in healthy men. J Endocrinol. 2009 Oct;203(1):175-9. doi: 10.1677/JOE-09-0227. Epub 2009 Jul 8.

Reference Type DERIVED
PMID: 19587265 (View on PubMed)

Other Identifiers

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EK-Nr.: 014/2006

Identifier Type: -

Identifier Source: secondary_id

2006-000246-39

Identifier Type: -

Identifier Source: org_study_id