Phase 3 Randomized Study of Telcyta + Doxorubicin Versus Doxorubicin in Platinum Refractory or Resistant Ovarian Cancer

NCT ID: NCT00350948

Last Updated: 2013-11-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

244 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-05-31

Study Completion Date

2008-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this research study is to determine if Telcyta® given in combination with liposomal doxorubicin is more effective than liposomal doxorubicin alone in treating women who have recurrent ovarian epithelial cancer, fallopian tube cancer or primary peritoneal cancer that is refractory or resistant to platinum chemotherapy.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This is a randomized, open label, multicenter, multinational Phase 3 study of TLK286 (Telcyta) in combination with liposomal doxorubicin (Doxil/Caelyx) as compared to the active control therapy with liposomal doxorubicin (Doxil/Caelyx) as second line therapy in patients with platinum refractory or resistant recurrent ovarian cancer. Patients will be randomly assigned to receive either TLK286 (Telcyta) in combination with liposomal doxorubicin (Doxil/Caelyx) or active control liposomal doxorubicin (Doxil/Caelyx).

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Ovarian Neoplasms

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

Ovary

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Telcyta + Liposomal Doxorubicin

Telcyta at 1000 mg/m2 followed by Liposomal Doxorubicin at 50 mg/m2 on Day 1 of each four-week treatment cycle

Group Type EXPERIMENTAL

Telcyta

Intervention Type DRUG

Day 1 of 28 day Cycle.

Liposomal Doxorubicin

Intervention Type DRUG

Day 1 of 28 Day Cycle. 50 mg/m2

Liposomal Doxorubicin

Liposomal Doxorubicin at 50 mg/m2 on Day 1 of each four-week treatment cycle

Group Type ACTIVE_COMPARATOR

Liposomal Doxorubicin

Intervention Type DRUG

Day 1 of 28 Day Cycle. 50 mg/m2

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Telcyta

Day 1 of 28 day Cycle.

Intervention Type DRUG

Liposomal Doxorubicin

Day 1 of 28 Day Cycle. 50 mg/m2

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

TLK286 canfosfamide Doxil Caelyx

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Are a woman 18 years of age or older
* Have histologically or cytologically confirmed epithelial cancer or primary peritoneal cancer
* Have platinum refractory or resistant cancer
* Measurable disease according to radiographic RECIST criteria progression

Exclusion Criteria

* Had treatment with first-line chemotherapy other than a platinum-containing regimen
* Have clinically significant cardiac disease
* Have any sign of intestinal obstruction interfering with nutrition
* Are pregnant or lactating
* Had prior treatment with liposomal doxorubicin
* Had prior treatment with Telcyta
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Telik

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Gail L. Brown, MD, MBA

Role: STUDY_DIRECTOR

Telik

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Desert Oasis Cancer Center

Casa Grande, Arizona, United States

Site Status

Hematology Oncology Services of Arkansas

Little Rock, Arkansas, United States

Site Status

University of Arkansas for Medical Sciences

Little Rock, Arkansas, United States

Site Status

East Bay Medical Oncology/Hematology Medical Associates, Inc.

Antioch, California, United States

Site Status

Bay Area Cancer Research Group, LLC

Concord, California, United States

Site Status

East Bay Medical Oncology/Hematology Medical Associates

Concord, California, United States

Site Status

California Oncology of the Central Valley

Fresno, California, United States

Site Status

Women's Cancer Research Foundation

Newport Beach, California, United States

Site Status

Southwest Cancer Care

Poway, California, United States

Site Status

Desert Hematology Oncology Medical Group

Rancho Mirage, California, United States

Site Status

Southern California Permanente Medical Group

San Diego, California, United States

Site Status

East Bay Medical Oncoogy/Hematology Medical Associates, Inc.

San Leandro, California, United States

Site Status

Diablo Valley Oncology & Hematology Medical Group, Inc.

Walnut Creek, California, United States

Site Status

Gynecologic Oncology Associates, Inc

Hollywood, Florida, United States

Site Status

Shands Jacksonville Medical Center

Jacksonville, Florida, United States

Site Status

University of Florida College of Medicine-Jacksonville

Jacksonville, Florida, United States

Site Status

Florida Hospital Cancer Institute

Orlando, Florida, United States

Site Status

Florida Hospital

Orlando, Florida, United States

Site Status

Gynecologic Oncology Associates, Inc

Pembroke Pines, Florida, United States

Site Status

Memorial Health University Medical Center

Savannah, Georgia, United States

Site Status

Kaiser Permanente Moanalua Medical Center

Honolulu, Hawaii, United States

Site Status

Flossmoor Cancer Care (JOHA DBA)

Flossmoor, Illinois, United States

Site Status

Joliet Oncology-Hematology Associates

Joliet, Illinois, United States

Site Status

Joliet Oncology-Hematology Associates, LTD.

Joliet, Illinois, United States

Site Status

Kankakee Cancer Center (JOHA DBA)

Kankakee, Illinois, United States

Site Status

Joliet Oncology-Hematology Associates

Morris, Illinois, United States

Site Status

St. Vincent Gynecologic Oncology

Indianapolis, Indiana, United States

Site Status

Central Baptist Hospital

Lexington, Kentucky, United States

Site Status

Hematology and Oncology Specialists, LLC

Metairie, Louisiana, United States

Site Status

LSU Health Sciences Center

Shreveport, Louisiana, United States

Site Status

Center for Cancer and Blood Disorders

Bethesda, Maryland, United States

Site Status

Arch Medical Services

St Louis, Missouri, United States

Site Status

Hematology & Oncology Consultants P.C.

Omaha, Nebraska, United States

Site Status

Horizon's West Medical Group

Scottsbluff, Nebraska, United States

Site Status

The Women's Center of Western Nebraska

Scottsbluff, Nebraska, United States

Site Status

Schwaartz Gynecologic Oncology, PLLC

Babylon, New York, United States

Site Status

The Mary Imogene Bassett Hospital

Cooperstown, New York, United States

Site Status

Monter Cancer Center

Lake Success, New York, United States

Site Status

North Shore University Hospital

Manhasset, New York, United States

Site Status

Long Island Jewish Medical Center

New Hyde Park, New York, United States

Site Status

Hope A Women's Cancer Center

Asheville, North Carolina, United States

Site Status

Blumenthal Cancer Center

Charlotte, North Carolina, United States

Site Status

Carolinas Medical Center

Charlotte, North Carolina, United States

Site Status

Presbyterian Hospital

Charlotte, North Carolina, United States

Site Status

Piedmont Hematology Oncology Associates-Lexington Satellite

Lexington, North Carolina, United States

Site Status

Piedmont Hematology Oncology Associates

Winston-Salem, North Carolina, United States

Site Status

Dakota Cancer Institute/Dakota Clinic Ltd.

Fargo, North Dakota, United States

Site Status

Gynecologic Oncology & Pelvic Surgery Associates

Columbus, Ohio, United States

Site Status

Garth Phibbs, M.D., FACOG

Toledo, Ohio, United States

Site Status

The Toledo Hospital

Toledo, Ohio, United States

Site Status

Kaiser Permanente NW, Oncology/Hematology

Portland, Oregon, United States

Site Status

Oregon Health & Science University

Portland, Oregon, United States

Site Status

Abington Memorial Hospital

Abington, Pennsylvania, United States

Site Status

Hematology & Oncology Associates of NEPA

Dunmore, Pennsylvania, United States

Site Status

Magee Women's Hospital of UPMC

Pittsburgh, Pennsylvania, United States

Site Status

Associates in Hematolog-Oncology, P.C.

Upland, Pennsylvania, United States

Site Status

Carolina Center of Gynecologic Oncology

Charleston, South Carolina, United States

Site Status

Palmetto Health Alliance-Richland

Columbia, South Carolina, United States

Site Status

South Carolina Oncology Associates

Columbia, South Carolina, United States

Site Status

Arlington Cancer Center

Arlington, Texas, United States

Site Status

Arlington Cancer Center

Trophy Club, Texas, United States

Site Status

Danville Hematology & Oncology, Inc.

Danville, Virginia, United States

Site Status

Carilion GYN Oncology Associates

Roanoke, Virginia, United States

Site Status

Algemeen Ziekenhuis Middelheim

Antwerp, , Belgium

Site Status

A.Z. Groeninge Oncologish Centrum

Kortrijk, , Belgium

Site Status

Universitaire Ziekenhuizen Leuven Dienst Oncologie

Leuven, , Belgium

Site Status

Hospital Vera Cruz-Instituto de Oncologia

Belo Horizonte, Minas Gerais, Brazil

Site Status

Centr de Oncologia do Instituto de Radiologia do Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo

Cerqueria Cesar, São Paulo, Brazil

Site Status

Fundacao Hospital Amaral Carvalho

Rua Dona Siilveria, São Paulo, Brazil

Site Status

Guy's & St. Thomas Cancer Centre

London, England, United Kingdom

Site Status

Ninewells Hospital and Medical School

Dundee, Scotland, United Kingdom

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States Belgium Brazil United Kingdom

References

Explore related publications, articles, or registry entries linked to this study.

Newhouse R, Nelissen E, El-Shakankery KH, Rogozinska E, Bain E, Veiga S, Morrison J. Pegylated liposomal doxorubicin for relapsed epithelial ovarian cancer. Cochrane Database Syst Rev. 2023 Jul 5;7(7):CD006910. doi: 10.1002/14651858.CD006910.pub3.

Reference Type DERIVED
PMID: 37407274 (View on PubMed)

Vergote I, Finkler NJ, Hall JB, Melnyk O, Edwards RP, Jones M, Keck JG, Meng L, Brown GL, Rankin EM, Burke JJ, Boccia RV, Runowicz CD, Rose PG. Randomized phase III study of canfosfamide in combination with pegylated liposomal doxorubicin compared with pegylated liposomal doxorubicin alone in platinum-resistant ovarian cancer. Int J Gynecol Cancer. 2010 Jul;20(5):772-80. doi: 10.1111/igc.0b013e3181daaf59.

Reference Type DERIVED
PMID: 20973267 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

TLK286.3025

Identifier Type: -

Identifier Source: org_study_id