Topical Vitamin B12 in Chronic Plaque Psoriasis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

48 participants

Study Classification

INTERVENTIONAL

Study Start Date

2001-01-31

Study Completion Date

2004-12-31

Brief Summary

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Objective: To test the efficacy and tolerability of a vitamin B12 cream for the treatment of chronic plaque psoriasis.

Design: Multicenter, double-blind, randomized, placebo-controlled trial.

Detailed Description

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Objective: To test the efficacy and tolerability of a vitamin B12 cream for the treatment of chronic plaque psoriasis.

Design: Multicenter, double-blind, randomized, placebo-controlled trial. Setting: ambulatory patients in research or referral centers. Patients: Volunteer sample of 51 patients with chronic plaque psoriasis. Interventions: All Patients applied vitamin B12 cream twice daily for 8 weeks to one side of the body and placebo to the other.

Main outcome measures: Modified Psoriasis Area and Severity Index (PASI) at weeks 0, 2, 4, 6 and 8. Thickness and density of 3 references plaques determined by 20 MHz sonography. Assessment of efficiency and tolerability by patients and investigators.

Conditions

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Chronic Plaque Psoriasis

Keywords

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plaque psoriasis Vitamin B12

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Interventions

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topical vitamin B12

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* 18years
* chronic plaque psoriasis

Exclusion Criteria

* incapability of Vitamin B12
* necessity of systemic therapy
* use of other potentially psoriasis modifying drugs

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Principal Investigators

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Peter Altmeyer, Prof. Dr.

Role: PRINCIPAL_INVESTIGATOR

Ruhr University Bochum, Dep. Dermatology and Allergology

Locations

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Dep. Dermatology and Allergology, Ruhr-University Bochum

Bochum, , Germany

Site Status

Countries

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Germany

Other Identifiers

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1-Stucker

Identifier Type: -

Identifier Source: org_study_id