Cytogenetic Study of Ocular Melanoma

NCT ID: NCT00344799

Last Updated: 2021-03-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

95 participants

Study Classification

OBSERVATIONAL

Study Start Date

2005-01-08

Study Completion Date

2020-10-23

Brief Summary

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Patients who are diagnosed with choroidal melanoma and undergo I-125 plaque or enucleation surgery consent to participate in the study. A tumor sample taken during surgery is studied in the lab for genetic features. These features and features of subjects' clinical course are recorded. Analysis of the data may identify genetic features that are indicative of prognostic factors including risk of metastasis.

Detailed Description

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The Jules Stein Eye Institute Ocular Melanoma Research Group is conducting cytogenetic studies of choroidal melanoma to improve the screening of biopsy samples of choroidal melanoma through cytogenetic analysis. Our goal is to identify molecular probes that specifically target regions of chromosomes that undergo changes characteristic of metastatic choroidal melanoma.

Conditions

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Choroidal Melanoma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

1. Patient with diagnosis of ocular melanoma
2. Patient with local treatment plan for ocular melanoma- plaque brachytherapy or enucleation
3. Patient 18 years of age or older
4. Archival enucleation specimens with diagnosis of ocular melanoma

Exclusion Criteria

1. Patient who refuses local melanoma treatment
2. Patient who refuses to participate in this study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Jonsson Comprehensive Cancer Center

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Tara M McCannel, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Jules Stein Eye Institute, UCLA

Bradley R Straatsma, MD, JD

Role: STUDY_DIRECTOR

Jules Stein Eye Institute, UCLA

Lynn Gordon, MD, PhD

Role: STUDY_CHAIR

Jules Stein Eye Institute, UCLA

Ben Glasgow, MD

Role: STUDY_CHAIR

Jules Stein Eye Institute, UCLA

Nagesh P Rao, PhD

Role: STUDY_CHAIR

UCLA Pathology and Laboratory Medicine

Locations

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Jules Stein Eye Institute

Los Angeles, California, United States

Site Status

Countries

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United States

References

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McCannel TA, Burgess BL, Nelson SF, Eskin A, Straatsma BR. Genomic identification of significant targets in ciliochoroidal melanoma. Invest Ophthalmol Vis Sci. 2011 May 9;52(6):3018-22. doi: 10.1167/iovs.10-5864.

Reference Type DERIVED
PMID: 20688739 (View on PubMed)

Other Identifiers

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11-000847

Identifier Type: OTHER

Identifier Source: secondary_id

UCLA IRB#04-12-084

Identifier Type: -

Identifier Source: org_study_id

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