Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
400 participants
OBSERVATIONAL
2006-04-07
2011-03-23
Brief Summary
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* Cancer stem cells in breast cancer have been identified as a small population of tumor cells whose self-renewal mechanism is highly deregulated. This deregulation seems to be necessary for cancer to develop.
* These cells can be identified by certain surface markers that overlap with markers associated with normal embryonic stem cells.
Objective: To isolate tumor stem cells using the same methods generally used to isolate human embryonic stem cells.
Eligibility:
* Tissue samples will be obtained from the human cooperative network.
* Samples will include normal tissues from individuals who have no opportunistic diseases and from individuals with cancer.
Design: Breast cancer stem cells will be isolated, grown in the laboratory and characterized.
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Detailed Description
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Recently, cancer stem cells have been identified as a small population of tumor cells which possess the stem cell properties in that their self-renewal pathway is highly deregulated. This deregulation seems to be the prerequisite for the development of cancer.
Conditions
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
ALL
No
Sponsors
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National Institutes of Health (NIH)
NIH
National Cancer Institute (NCI)
NIH
Locations
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National Cancer Institute (NCI), 9000 Rockville Pike
Bethesda, Maryland, United States
Countries
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Other Identifiers
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06-C-N140
Identifier Type: -
Identifier Source: secondary_id
999906140
Identifier Type: -
Identifier Source: org_study_id
NCT00900315
Identifier Type: -
Identifier Source: nct_alias
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