The Effects of Levetiracetam on Alcohol Dependent Subjects

NCT ID: NCT00325182

Last Updated: 2017-03-15

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE4
• Total Enrollment: 40 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2006-01-31
• Study Completion Date: 2009-10-31

Brief Summary

This study will attempt to examine whether Levetiracetam (Keppra (TM)) can help people with alcohol dependence cut down on their alcohol consumption. In addition, the investigation will assess the effectiveness of Keppra on reducing withdrawal symptoms post alcohol cessation. Matched group of historical controls of alcohol dependent patients receiving placebo will be used for comparison.Based on the mechanism of action of Keppra we hypothesize that it may be effective in promoting abstinence and reducing drinking behavior in alcohol dependent patients.

Detailed Description

Alcoholism is a chronic disease with numerous psychological, social and medical consequences. Alcohol use disorders are one of the most prevalent psychiatric disorders in general population in the US. Alcoholism not only disrupts an individual's life, health and ability to function in the society, has tremendous impact on families and communities, but also is associated with enormous economic cost for society. The medical and social impact of alcoholism can be reduced via effective treatments. Although medical, psychological and social approaches have demonstrated some efficacy, no specific method has consistently shown superiority. Similarly, currently available pharmacological treatments for alcohol use disorders are associated with moderate efficacy, indicating that further efforts are required to develop novel interventions.

The rewarding effects of alcohol are at least partially mediated via dopamine pathways that originate in the ventral tegmental area and project to the nucleus accumbens. Alcohol through its effects on GABA receptor activity decreases the inhibitory effect of GABA on the dopaminergic neurons in ventral tegmental area and therefore facilitates dopamine neurotransmission. Medications that modulate excitatory neurotransmission in the brain (glutamate) and facilitate inhibitory effects of GABA have been shown to be clinically effective in treatment of alcoholism.

Keppra is a novel antiepileptic medication currently approved for treatment of partial onset seizures as an adjunctive agent. It has a unique mechanism of action in that it reduces negative allosteric effects of Zn++ and Beta- carboline in two main inhibitory receptors in the CNS- the GABA A and glycine receptors. These modulators inhibit the influx of chloride though both of these receptor complexes and are therefore considered excitatory mediators. Keppra prevents the negative modulation and promotes chloride flux, thereby, inhibiting neurotransmission.

Limited laboratory work with levetiracetam (Keppra) has shown that the medication can reverse the anxiogenic effect of benzodiazepine withdrawal in mice (Y. Lamberty et al., 2002). Furthermore, Keppra was investigated for its potential to prevent alcohol withdrawal symptoms in mice. In this study levetiracetam dose-dependently prevented spontaneous tremors and handling induced convulsions in alcohol dependent mice. (Y. Lamberty et al., 2002). Based on the mechanism of action of Keppra we hypothesize that it may be effective in promoting abstinence and reducing drinking behavior in alcohol dependent patients.

Conditions

Alcoholism

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Intervention: Levetiracetam

Levetiracetam dose schedule Days 1-4 250 mg bid Days 5- 19 500 mg bid Days 20 -70 1000 mg bid Days 71-78 500 mg bid Days 79-85 250 mg bid Days 86-91

Group Type: EXPERIMENTAL

Levetiracetam

Intervention Type: DRUG

Historical controls

Historical controls from COMBINE study who receive a placebo

Group Type: PLACEBO_COMPARATOR

Historical controls

Intervention Type: OTHER

Interventions

Levetiracetam

Intervention Type: DRUG

Historical controls

Intervention Type: OTHER

Other Intervention Names

Keppra

Eligibility Criteria

Inclusion Criteria

• DSM IV TR Diagnosis of Alcohol Dependence
• Male or female age 21-60 years old
• Able to provide informed consent and comprehend study procedures
• Negative urine toxicological screen for narcotics, amphetamines, sedative hypnotics and cannabinoids. The test may be repeated within a week.
• Score of > 8 on Alcohol Use Disorder Identification Test during screening
• Must be suitable for outpatient management
• Express desire to stop drinking or reduce alcohol consumption with possible long-term goal of abstinence.
• Provide contact information for themselves or an alternate contact that the study staff will contact in case of missed appointment.
• Female subjects must be postmenopausal for at least one year, or practicing an effective method of birth control before entry and throughout the study
• Must be able to take oral medications, adhere to regimen and be willing to return for follow up visits
• Must have breath alcohol concentration of no more than 0.025% when signing the informed consent

Exclusion Criteria

• Dependent on or extensive abuse of drugs or substances other than ethanol, nicotine or caffeine
• DSM IV- TR diagnosis of any current Axis I diagnosis other than alcohol, nicotine or caffeine dependence that in the investigator's judgment might require intervention with either pharmacological or non-pharmacological therapy that might interfere with the course of the study
• Receiving inpatient or outpatient treatment for alcohol dependence (with the exception of AA or other self-help groups) within the 4 weeks prior to enrollment
• Subjects with a score of 10 or greater on the CIWA-Ar at visits one and two
• Currently being treated with disulfiram or naltrexone
• Currently being treated with any the following medications: a) Antipsychotic agent [b) Lithium Carbonate c) Anticonvulsant agent d) Hypnotics e) Antianxiety Agents f) Chronic opiate treatment with methadone, laam, buprenorphine; oxycodone, morphine, etc g) Stimulant treatment
• Subjects who are legally mandated to participate in alcohol treatment program
• Subjects who have had a suicide attempt or suicidal ideation within 30 days of the first visit
• Subjects with renal disease
• Subjects with AST and ALT >3 times the upper limit of the normal range during screening. Test may be repeated prior to enrollment. If repeat lab values are all within acceptable ranges subject may continue study participation.
• Major neurological disorder including seizures
• Subjects who are pregnant or lactating
• Subjects known to have clinically significant medical conditions, including, but not limited to: symptomatic CAD or PVD, malignancy or history of malignancy in the last 5 years, pulmonary disorders, endocrinological disorders
• Subjects with prior hypersensitivity to Keppra
• Subjects with history of medically complicated withdrawal from alcohol.
• Subjects who in the opinion of the investigator should not be enrolled in the study because of the precautions, warnings and contraindications outlined in the Keppra package insert
• Subjects with cardiac pacemaker or metal surgical implant

• Minimum Eligible Age: 21 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

UCB Pharma

INDUSTRY

Sponsor Role: collaborator

Boston University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Ofra Sarid-Segal, MD

Role: PRINCIPAL_INVESTIGATOR

Boston University

Locations

Boston University Dept of Psychiatry Clinical Studies Unit

Boston, Massachusetts, United States

Countries

United States

Other Identifiers

H-23008

Identifier Type: -

Identifier Source: org_study_id