Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
Recruitment Status
COMPLETED
Clinical Phase
PHASE4
Total Enrollment
200 participants
Study Classification
INTERVENTIONAL
Study Start Date
2006-04-30
Study Completion Date
2008-09-30
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
The purpose of the study is to determine the analgetic effect of nitrous oxide during colonoscopy, compared to no sedation and intravenous (IV) sedation.
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Background
Colonoscopy is the gold standard for diagnosis and endoscopic treatment of diseases in the colon and rectum (1). However, many patients experience discomfort during the procedure. Therefore, IV sedation and/or analgesia is routinely given during colonoscopy at the majority of centers around the world.
Midazolam, the most frequent sedative, is a benzodiazepine with hypnotic and sedative effects (2). The half-life of the substance is about 1-2.5 hours, and thus substantially longer than the duration of a colonoscopy (approximately 30 minutes). Additionally, Midazolam gives pronounced amnesia that lasts even longer than the hypnotic effect. Opioids are also frequently used during colonoscopy, with Pethidine as the most common one (half-life: 3 hours).
Use of the above mentioned drugs make it necessary to closely monitor the patients after colonoscopy for several hours, often in specially designed resource-demanding recovery units. Furthermore, due to the amnesia, it is often not possible to give information about findings and further work-up or surveillance to patients after colonoscopy. Finally, patients are not allowed to drive a car for the rest of the day after IV sedation during colonoscopy (2).
Nitrous oxide (N2O) is used as an inhalative gas during anesthesia, labour and at some dentist practices, most frequent in a fixed 50:50 combination with O2. N2O has a strong analgetic effect, and none or only slight sedative effects in concentrations \< 80%. N2O has a very rapid onset of effect (a few seconds), and its half-life in the human body after the stop of inhalation is shorter than 1 minute (3). Patients receiving N2O in a 50:50 combination with O2 are awake, don't need post-procedure recovery and may drive their own car home (4). However, as N2O diffuses quickly through biological membranes, caution is warranted when used for patients with the following conditions: sinusitis, otitis, ileus, bowl obstruction, and megacolon. Pregnant women should not be exposed to N2O.
There are some small studies showing good analgetic effects of N2O during colonoscopy, without significant side-effects (5,6,7). One additional study, however, reported on the poor effects of N2O during colonoscopy (8). This study has, however, been subject for critique because it lacks in methodology (9).
N2O is currently used only at some hospitals around the world.
The use of N2O in colonoscopy instead of IV drugs seems to be attractive for several reasons:
* Adequate analgesia without disturbing sedation during the procedure. The patient is awake and co-operative.
* No amnesia. All information can be given to the patient immediately after the procedure.
* The patient can control inhalation of the analgetic N2O himself. This may enhance patient satisfaction.
* Rapid stop of effect after stopped administration. No surveillance needed, patients can leave the hospital immediately.
* N2O does not impair psychomotoric abilities (4,10). Thus, patients may use their own car to and from the appointment. This is resource-sparing for the patient and/or payer. Moreover, it may increase compliance for colonoscopy in rural areas.
Hypothesis/endpoint
Primary endpoint:
* Does the use of N2O during colonoscopy result in adequate analgesia for the patient?
Secondary endpoints
* Are there any side-effects due to the use of N2O during colonoscopy?
* Is there a reduction in the number of patients needing IV sedation?
* Is there any dose reduction of IV drugs?
Methods
The study is a randomised, controlled, double-blinded, single-center trial. Participants, after giving written informed consent, are randomised to one of two treatment groups:
1. Group 1: N2O inhalation (verum)
2. Group 2: O2 inhalation (placebo)
All patients in both groups will start their examination without any use of sedatives/analgetics. On demand, the patients will then be instructed to use the mask for inhalation of gas (N2O in verum group, O2 in placebo group). In case of insufficient effect of inhalation, patients in both groups will be given midazolam and/or pethidine until satisfactorily relieved from pain or discomfort.
Both the patient and the endoscopist are blinded with regard to the type of gas used. The endoscopy assistant handles the gas couplings on scene. Randomisation will be done 1:1 for the groups, in blocks of 6 patients, using a computer program and sealed envelopes for concealment on scene.
Study medication
N2O or O2 is to be administrated by inhalation via a mouth/nose mask. N2O and O2 is delivered by the central hospital gas system. The mask contains a tight circle, where gas is only released from the mask by negative pressure from inspiration of the patient. This is to prevent leakage of gas to the environment. The mask is held by the patient and the patient controls the use of the mask (patient-controlled analgesia). The gas system has been approved by the local department of medical equipment. Measurements of N2O concentrations in the endoscopy room are frequently performed by an independent body, in accordance with Norwegian law.
Midazolam (standard dose 2.5 mg) and pethidin (standard dose 25 mg) are used as IV drugs.
Stopping rules
If any adverse effects are observed, blinding is to be broken. The endoscopist decides changes in the sedation procedure, as appropriate in the individual situation.
Measurement of pain and discomfort
After the examination, study participants receive a questionnaire about pain and discomfort during and after the examination. This questionnaire has been used in our department for several years, and is validated for the use in colonoscopy (11, 12). The questionnaire contains a 4-point scale (4-VRS) for the patient's characterisation of pain and discomfort. Additionally, the questionnaire asks about any side-effects observed by the patient.
The questionnaire is to be filled in by the patient at home the day after the procedure, and to be mailed back to the center in a prepaid envelope.
Exclusion criteria:
1. Patients who don't understand information given
2. Age under 18 years
3. Pregnancy
4. Otitis/sinusitis
5. Ileus/bowel obstruction
6. Megacolon
7. Suspected pneumothorax
Power calculation
As there is only limited knowledge from the literature, we will perform a pilot study including 10 patients in each group. The data of the pilot study will then serve for a power calculation to find out the number of individuals needed in the study.
Ethics
The Norwegian version of the protocol has been approved by the regional ethics committee of Southern Norway (no. S-05225). The Norwegian Data Inspectorate has been informed about the study (no. 25660). The study is registered in a clinical trials registry (www.clinicaltrials.gov).
Ownership and publication
All generated data are owned by Rikshospitalet University Hospital. A manuscript dealing with the data will be submitted to a medical journal for publication, regardless of the nature of the results. Authorship will be according to the Vancouver rules (13).
Literature
1. Aabakken L. Gastrointestinal endoskopi. Oslo 1997
2. Felleskatalogen 2004. Felleskatalogen as, Oslo 2004
3. Forth W, et al. Pharmakologie und Toxikologie. Wissenschaftsverlag. Mannheim 1992
4. Martin JP, et al. Inhaled patient-administered nitrous oxide/oxygen mixture does not impair driving ability when using as analgesia during screening flexible sigmoidoscopy. Gastrointest Endosc 2000;51:701-3.
5. Harding TA, et al. The use of inhaled nitrous oxide for flexible sigmoidoscopy: a placebo-controlled trial. Endoscopy 2000;32:457-80
6. Notini-Gudmarson AK, et al. Nitrous oxide: a valuable alternative for pain relief and sedation during routine colonoscopy Endoscopy 1996;28:283-7
7. Hedenbro J, et al. Lustgas øverlæget vid koloskopi. Lakartidningen 1996;93:257-8
8. Forbes GM, Collins BJ. Nitrous oxide for colonoscopy; a randomized controlled study. Gastrointest Endosc 2000;51:271-7.
9. Faddy SC. Substantial surveillance bias in an unblended study of pain and adverse effects associated with nitrous oxide inhalation or standard medication for colonoscopy. Gastrointest Endosc 2001;54 (letter).
10. Trojan J, et al. Immediate recovery of psychomotor function after patient-administered nitrous oxide/oxygen inhalation for colonoscopy. Endoscopy 1997;29:17-22
11. Bretthauer M, et al. A randomized controlled trial to assess the safety and efficacy of carbon dioxide insufflation in colonoscopy. Gut 2002;50:604-7
12. Skovlund E, et al. Sensitivity of pain rating scales in an endoscopy trial. J Clin Pain, 2005, in press
13. Uniform requirements for manuscripts submitted to biomedical journals: writing and editing for biomedical
Colonoscopy is the gold standard for diagnosis and endoscopic treatment of diseases in the colon and rectum (1). However, many patients experience discomfort during the procedure. Therefore, IV sedation and/or analgesia is routinely given during colonoscopy at the majority of centers around the world.
Midazolam, the most frequent sedative, is a benzodiazepine with hypnotic and sedative effects (2). The half-life of the substance is about 1-2.5 hours, and thus substantially longer than the duration of a colonoscopy (approximately 30 minutes). Additionally, Midazolam gives pronounced amnesia that lasts even longer than the hypnotic effect. Opioids are also frequently used during colonoscopy, with Pethidine as the most common one (half-life: 3 hours).
Use of the above mentioned drugs make it necessary to closely monitor the patients after colonoscopy for several hours, often in specially designed resource-demanding recovery units. Furthermore, due to the amnesia, it is often not possible to give information about findings and further work-up or surveillance to patients after colonoscopy. Finally, patients are not allowed to drive a car for the rest of the day after IV sedation during colonoscopy (2).
Nitrous oxide (N2O) is used as an inhalative gas during anesthesia, labour and at some dentist practices, most frequent in a fixed 50:50 combination with O2. N2O has a strong analgetic effect, and none or only slight sedative effects in concentrations \< 80%. N2O has a very rapid onset of effect (a few seconds), and its half-life in the human body after the stop of inhalation is shorter than 1 minute (3). Patients receiving N2O in a 50:50 combination with O2 are awake, don't need post-procedure recovery and may drive their own car home (4). However, as N2O diffuses quickly through biological membranes, caution is warranted when used for patients with the following conditions: sinusitis, otitis, ileus, bowl obstruction, and megacolon. Pregnant women should not be exposed to N2O.
There are some small studies showing good analgetic effects of N2O during colonoscopy, without significant side-effects (5,6,7). One additional study, however, reported on the poor effects of N2O during colonoscopy (8). This study has, however, been subject for critique because it lacks in methodology (9).
N2O is currently used only at some hospitals around the world.
The use of N2O in colonoscopy instead of IV drugs seems to be attractive for several reasons:
* Adequate analgesia without disturbing sedation during the procedure. The patient is awake and co-operative.
* No amnesia. All information can be given to the patient immediately after the procedure.
* The patient can control inhalation of the analgetic N2O himself. This may enhance patient satisfaction.
* Rapid stop of effect after stopped administration. No surveillance needed, patients can leave the hospital immediately.
* N2O does not impair psychomotoric abilities (4,10). Thus, patients may use their own car to and from the appointment. This is resource-sparing for the patient and/or payer. Moreover, it may increase compliance for colonoscopy in rural areas.
Hypothesis/endpoint
Primary endpoint:
* Does the use of N2O during colonoscopy result in adequate analgesia for the patient?
Secondary endpoints
* Are there any side-effects due to the use of N2O during colonoscopy?
* Is there a reduction in the number of patients needing IV sedation?
* Is there any dose reduction of IV drugs?
Methods
The study is a randomised, controlled, double-blinded, single-center trial. Participants, after giving written informed consent, are randomised to one of two treatment groups:
1. Group 1: N2O inhalation (verum)
2. Group 2: O2 inhalation (placebo)
All patients in both groups will start their examination without any use of sedatives/analgetics. On demand, the patients will then be instructed to use the mask for inhalation of gas (N2O in verum group, O2 in placebo group). In case of insufficient effect of inhalation, patients in both groups will be given midazolam and/or pethidine until satisfactorily relieved from pain or discomfort.
Both the patient and the endoscopist are blinded with regard to the type of gas used. The endoscopy assistant handles the gas couplings on scene. Randomisation will be done 1:1 for the groups, in blocks of 6 patients, using a computer program and sealed envelopes for concealment on scene.
Study medication
N2O or O2 is to be administrated by inhalation via a mouth/nose mask. N2O and O2 is delivered by the central hospital gas system. The mask contains a tight circle, where gas is only released from the mask by negative pressure from inspiration of the patient. This is to prevent leakage of gas to the environment. The mask is held by the patient and the patient controls the use of the mask (patient-controlled analgesia). The gas system has been approved by the local department of medical equipment. Measurements of N2O concentrations in the endoscopy room are frequently performed by an independent body, in accordance with Norwegian law.
Midazolam (standard dose 2.5 mg) and pethidin (standard dose 25 mg) are used as IV drugs.
Stopping rules
If any adverse effects are observed, blinding is to be broken. The endoscopist decides changes in the sedation procedure, as appropriate in the individual situation.
Measurement of pain and discomfort
After the examination, study participants receive a questionnaire about pain and discomfort during and after the examination. This questionnaire has been used in our department for several years, and is validated for the use in colonoscopy (11, 12). The questionnaire contains a 4-point scale (4-VRS) for the patient's characterisation of pain and discomfort. Additionally, the questionnaire asks about any side-effects observed by the patient.
The questionnaire is to be filled in by the patient at home the day after the procedure, and to be mailed back to the center in a prepaid envelope.
Exclusion criteria:
1. Patients who don't understand information given
2. Age under 18 years
3. Pregnancy
4. Otitis/sinusitis
5. Ileus/bowel obstruction
6. Megacolon
7. Suspected pneumothorax
Power calculation
As there is only limited knowledge from the literature, we will perform a pilot study including 10 patients in each group. The data of the pilot study will then serve for a power calculation to find out the number of individuals needed in the study.
Ethics
The Norwegian version of the protocol has been approved by the regional ethics committee of Southern Norway (no. S-05225). The Norwegian Data Inspectorate has been informed about the study (no. 25660). The study is registered in a clinical trials registry (www.clinicaltrials.gov).
Ownership and publication
All generated data are owned by Rikshospitalet University Hospital. A manuscript dealing with the data will be submitted to a medical journal for publication, regardless of the nature of the results. Authorship will be according to the Vancouver rules (13).
Literature
1. Aabakken L. Gastrointestinal endoskopi. Oslo 1997
2. Felleskatalogen 2004. Felleskatalogen as, Oslo 2004
3. Forth W, et al. Pharmakologie und Toxikologie. Wissenschaftsverlag. Mannheim 1992
4. Martin JP, et al. Inhaled patient-administered nitrous oxide/oxygen mixture does not impair driving ability when using as analgesia during screening flexible sigmoidoscopy. Gastrointest Endosc 2000;51:701-3.
5. Harding TA, et al. The use of inhaled nitrous oxide for flexible sigmoidoscopy: a placebo-controlled trial. Endoscopy 2000;32:457-80
6. Notini-Gudmarson AK, et al. Nitrous oxide: a valuable alternative for pain relief and sedation during routine colonoscopy Endoscopy 1996;28:283-7
7. Hedenbro J, et al. Lustgas øverlæget vid koloskopi. Lakartidningen 1996;93:257-8
8. Forbes GM, Collins BJ. Nitrous oxide for colonoscopy; a randomized controlled study. Gastrointest Endosc 2000;51:271-7.
9. Faddy SC. Substantial surveillance bias in an unblended study of pain and adverse effects associated with nitrous oxide inhalation or standard medication for colonoscopy. Gastrointest Endosc 2001;54 (letter).
10. Trojan J, et al. Immediate recovery of psychomotor function after patient-administered nitrous oxide/oxygen inhalation for colonoscopy. Endoscopy 1997;29:17-22
11. Bretthauer M, et al. A randomized controlled trial to assess the safety and efficacy of carbon dioxide insufflation in colonoscopy. Gut 2002;50:604-7
12. Skovlund E, et al. Sensitivity of pain rating scales in an endoscopy trial. J Clin Pain, 2005, in press
13. Uniform requirements for manuscripts submitted to biomedical journals: writing and editing for biomedical
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Pain
Keywords
Explore important study keywords that can help with search, categorization, and topic discovery.
Pain
Colonoscopy
Sedation
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
Allocation Method
RANDOMIZED
Intervention Model
SINGLE_GROUP
Primary Study Purpose
TREATMENT
Blinding Strategy
DOUBLE
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Nitrous oxide
Intervention Type
DRUG
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Patients referred for colonoscopy
Exclusion Criteria
* Patients who don't understand information given
* Age under 18 years
* Pregnancy
* Otitis/sinusitis
* Ileus/bowel obstruction
* Megacolon
* Suspected pneumothorax
* Age under 18 years
* Pregnancy
* Otitis/sinusitis
* Ileus/bowel obstruction
* Megacolon
* Suspected pneumothorax
Minimum Eligible Age
18 Years
Maximum Eligible Age
90 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Rikshospitalet University Hospital
OTHER
Sponsor Role
lead
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Michael Bretthauer, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Oslo University Hospital
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Rikshospitalet University Hospital
Oslo, , Norway
Site Status
Countries
Review the countries where the study has at least one active or historical site.
Norway
References
Explore related publications, articles, or registry entries linked to this study.
Loberg M, Furholm S, Hoff I, Aabakken L, Hoff G, Bretthauer M. Nitrous oxide for analgesia in colonoscopy without sedation. Gastrointest Endosc. 2011 Dec;74(6):1347-53. doi: 10.1016/j.gie.2011.07.071.
Reference Type
DERIVED
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
s-05225
Identifier Type: -
Identifier Source: org_study_id