Safety Study of Apixaban in Recent Acute Coronary Syndrome

NCT ID: NCT00313300

Last Updated: 2015-12-30

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

1741 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-05-31

Study Completion Date

2008-05-31

Brief Summary

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The purpose of this clinical research study is to determine whether apixaban will be safe in people who have recently had unstable angina or a heart attack.

Detailed Description

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Conditions

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Acute Coronary Syndrome (ACS)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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A1

Group Type ACTIVE_COMPARATOR

Apixaban

Intervention Type DRUG

Tablets, Oral, 2.5 mg, twice daily, 26 weeks

A2

Group Type EXPERIMENTAL

Apixaban

Intervention Type DRUG

Tablets, Oral, 10 mg, once daily, 26 weeks

A3

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Tablets, Oral, 0, twice daily, 26 weeks

A4

Group Type EXPERIMENTAL

Apixaban

Intervention Type DRUG

Tablets, Oral 10 mg, twice daily, 26 weeks

Interventions

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Apixaban

Tablets, Oral, 2.5 mg, twice daily, 26 weeks

Intervention Type DRUG

Apixaban

Tablets, Oral, 10 mg, once daily, 26 weeks

Intervention Type DRUG

Placebo

Tablets, Oral, 0, twice daily, 26 weeks

Intervention Type DRUG

Apixaban

Tablets, Oral 10 mg, twice daily, 26 weeks

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Recent (\< = 7 days) Acute Coronary Syndrome (ACS).
* Clinically stable on optimal treatment

Exclusion Criteria

* High bleeding risk.
* Ongoing anticoagulant use.
* Need for chronic (\>3 months) daily nonsteroidal anti-inflammatory drug (NSAID) or chronic high dose acetylsalicylic acid (ASA) use (\>325 mg/day
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bristol-Myers Squibb

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bristol-Myers Squibb

Role: STUDY_DIRECTOR

Bristol-Myers Squibb

Locations

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Scottsdale Cardiovasular Research Institute

Scottsdale, Arizona, United States

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Los Angeles County & University Of Southern Ca. Medical Cen.

Los Angeles, California, United States

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Radiant Research,Santa Rosa

Santa Rosa, California, United States

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South Denver Cardiology Associates

Littleton, Colorado, United States

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Watson Clinic Center For Research

Lakeland, Florida, United States

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Heart & Vasc Inst Of Fl

Safety Harbor, Florida, United States

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Indian River Medical Center

Vero Beach, Florida, United States

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Cardiac Disease Specialists, P.C.

Atlanta, Georgia, United States

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Georgia Heart Specialists

Covington, Georgia, United States

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Heartcare Midwest

Peoria, Illinois, United States

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The Care Group, Llc.

Indianapolis, Indiana, United States

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Iowa Heart Center

Des Moines, Iowa, United States

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University Of Kentucky

Lexington, Kentucky, United States

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William Beaumont Hospital-Troy

Troy, Michigan, United States

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New York Cardiovascular Associates

New York, New York, United States

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Unc Hospitals, Department Of Medicine

Chapel Hill, North Carolina, United States

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Dumc

Durham, North Carolina, United States

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Carolina Heart Specialists

Gastonia, North Carolina, United States

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Piedmont Cardiology Associates

Hickory, North Carolina, United States

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Wake Forest Univ Health Sciences

Winston-Salem, North Carolina, United States

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Midwest Cardiology Research Foundation

Columbus, Ohio, United States

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The Dayton Heart Center

Dayton, Ohio, United States

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Oklahoma Cardiovascular Research Group

Oklahoma City, Oklahoma, United States

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Geisinger Clinic - Cardiology

Danville, Pennsylvania, United States

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Penn State Milton S. Hershey Medical Center

Hershey, Pennsylvania, United States

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Rhode Island Hospital

Providence, Rhode Island, United States

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Cardiovascular Associates, P.C

Kingsport, Tennessee, United States

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University Of Texas Medical School - San Antonio

San Antonio, Texas, United States

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Tyler Cardiovascular Consultants

Tyler, Texas, United States

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Virginia Commonwealth University

Richmond, Virginia, United States

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Local Institution

Feldkirch, , Austria

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Vienna, , Austria

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Vienna, , Austria

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Huy, Luik, Belgium

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Aalst, , Belgium

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Antwerp, , Belgium

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Brasschaat, , Belgium

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Bruges, , Belgium

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Brussels, , Belgium

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Genk, , Belgium

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Edmonton, Alberta, Canada

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Edmonton, Alberta, Canada

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Edmonton, Alberta, Canada

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Victoria, British Columbia, Canada

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St. John's, Newfoundland and Labrador, Canada

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Belleville, Ontario, Canada

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Chatham, Ontario, Canada

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Hamilton, Ontario, Canada

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London, Ontario, Canada

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Oshawa, Ontario, Canada

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Montreal, Quebec, Canada

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Montreal, Quebec, Canada

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Montreal, Quebec, Canada

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Saint-Charles-Borromée, Quebec, Canada

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Terrebonne, Quebec, Canada

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Arhus C, , Denmark

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Copenhagen, , Denmark

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Esbjerg, , Denmark

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Frederiksberg, , Denmark

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Glostrup Municipality, , Denmark

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Hellerup, , Denmark

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Herning, , Denmark

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Randers, , Denmark

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Amiens, , France

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Cholet, , France

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Dijon, , France

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Nantes, , France

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Paris, , France

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Pessac, , France

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Roubaix, , France

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Toulouse, , France

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Berlin, , Germany

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Berlin, , Germany

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Düren, , Germany

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Halle, , Germany

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Hanover, , Germany

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Krefeld, , Germany

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Langen, , Germany

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Ludwigshafen, , Germany

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Witten, , Germany

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Afula, , Israel

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Hadera, , Israel

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Haifa, , Israel

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Haifa, , Israel

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Jerusalem, , Israel

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Jerusalem, , Israel

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Jerusalem, , Israel

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Kfar Saba, , Israel

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Nazareth, , Israel

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Petah Tikva, , Israel

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Rehovot, , Israel

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Safed, , Israel

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Tel Aviv, , Israel

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Roma, , Italy

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Bialystok, , Poland

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Bydgoszcz, , Poland

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Bydgoszcz, , Poland

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Bydgoszcz, , Poland

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Gdansk, , Poland

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Katowice, , Poland

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Krakow, , Poland

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Krakow, , Poland

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Lodz, , Poland

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Opole, , Poland

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Torun, , Poland

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Warsaw, , Poland

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Zielona Góra, , Poland

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Kemerovo, , Russia

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Moscow, , Russia

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Moscow, , Russia

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Moscow, , Russia

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Moscow, , Russia

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Moscow, , Russia

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Moscow, , Russia

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Moscow, , Russia

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Saint Petersburg, , Russia

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Saint Petersburg, , Russia

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Saint Petersburg, , Russia

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Saint Petersburg, , Russia

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Saint Petersburg, , Russia

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Saint Petersburg, , Russia

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Saratov, , Russia

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Yaroslavl, , Russia

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Yaroslav, , Russia

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Baracaldo (Vizcaya), , Spain

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Barcelona, , Spain

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Hospitalet Llobregat Barcelona, , Spain

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León, , Spain

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Madrid, , Spain

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Málaga, , Spain

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Oviedo, , Spain

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Santiago de Compostela, , Spain

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Seville, , Spain

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Tarragona, , Spain

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Valladolid, , Spain

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Villajoyosa, , Spain

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Gothenburg, , Sweden

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Gothenburg, , Sweden

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Malmo, , Sweden

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Örebro, , Sweden

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Stockholm, , Sweden

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Sundsvall, , Sweden

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Uppsala, , Sweden

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Stockport, Cheshire, United Kingdom

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Harrow, Middlesex, United Kingdom

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Edinburgh, Midlothian, United Kingdom

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Portadown, Northern Ireland, United Kingdom

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Sheffield, South Yorkshire, United Kingdom

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York, Yorkshire, United Kingdom

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Croydon, , United Kingdom

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Leicester, , United Kingdom

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Countries

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Netherlands United States Austria Belgium Canada Denmark France Germany Israel Italy Poland Russia Spain Sweden United Kingdom

References

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APPRAISE Steering Committee and Investigators; Alexander JH, Becker RC, Bhatt DL, Cools F, Crea F, Dellborg M, Fox KA, Goodman SG, Harrington RA, Huber K, Husted S, Lewis BS, Lopez-Sendon J, Mohan P, Montalescot G, Ruda M, Ruzyllo W, Verheugt F, Wallentin L. Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: results of the Apixaban for Prevention of Acute Ischemic and Safety Events (APPRAISE) trial. Circulation. 2009 Jun 9;119(22):2877-85. doi: 10.1161/CIRCULATIONAHA.108.832139. Epub 2009 May 26.

Reference Type DERIVED
PMID: 19470889 (View on PubMed)

Other Identifiers

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CV185-023

Identifier Type: -

Identifier Source: org_study_id