Obstructive Sleep Apnea Syndrome in Glaucoma

NCT ID: NCT00313092

Last Updated: 2015-10-02

Basic Information

• Recruitment Status: TERMINATED
• Total Enrollment: 60 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2005-01-31
• Study Completion Date: 2005-09-30

Brief Summary

The aim of the study is to determine if plasma matrix-metalloproteinase activity can predict glaucoma in patients with OSAS and if the level of plasma matrix-metalloproteinase activity will decrease after one month of nCPAP-treatment.

Detailed Description

Glaucoma is a leading cause of blindness world-wide. Chronic primary open-angle glaucoma is the most common form among Caucasian patients. The key feature of glaucoma is damage to the optic nerve head, which is not necessarily related to an increased intraocular pressure. The prevalence of glaucoma among the patients with sleep apnoea was 7,2%: normal-tension glaucoma 2,9%, primary open-angle glaucoma 4,3%. The prevalence of obstructive sleep apnoea syndrome (OSAS) is around 4-10% for men and 2-4% for women. Matrix metalloproteinases (MMPs) substrates include essentially all extracellular matrix components as well as a wide array of molecules involved in intracellular adhesion, cell-matrix interaction, and cell signalling. However, MMPs effects are not restricted to extracellular matrix degradation. The prevalence of increased MMP in patients with OSAS and its predicting value for an additional glaucoma are not known. Further, we do not know if treatment of OSAS with nasal continuous positive air pressure(nCPAP) can decrease the MMP activity. With this study, we want to determine the prevalence of MMP activity and the prevalence of glaucoma in patients with OSAS. Further, we want to investigate if a nCPAP treatment period of four weeks decreases the MMP activity.

Conditions

Obstructive Sleep Apnea Syndrome; Glaucoma

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: PROSPECTIVE

Interventions

nCPAP treatment

treatment with positive air pressure during night

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• OSAS planned begin of a nCPAP treatment

Exclusion Criteria

• Current malignancy
• Oral steroids

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 95 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University Hospital, Basel, Switzerland

OTHER

Sponsor Role: collaborator

Selim Orguel

OTHER

Sponsor Role: lead

Responsible Party

Selim Orguel

Prof. Dr.

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Selim Orgül, MD

Role: STUDY_DIRECTOR

University Eye Clinic Basel

Locations

University Hospital Basel, Eye Clinic

Basel, Canton of Basel-City, Switzerland

Countries

Switzerland

Other Identifiers

045-LEJ-2004-002

Identifier Type: -

Identifier Source: org_study_id