Efficacy and Safety Trial of SLITone(TM) Birch in Subjects With Hayfever

NCT ID: NCT00310466

Last Updated: 2013-05-14

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

226 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-06-30

Study Completion Date

2007-01-31

Brief Summary

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The trial is performed to assess the efficacy and safety of SLIT One birch for treatment of birch pollen induced allergy

Detailed Description

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Daily rhinoconjunctivits symptom and medication scores from patient diaries, adverse events

Conditions

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Allergy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Sublingual immunotherapy

sublingual immunotherapy with drops applied once daily by single dose containers (200 STU per dose)

Group Type ACTIVE_COMPARATOR

Sublingual immunotherapy

Intervention Type BIOLOGICAL

once daily intake of sublingual drops

Placebo

placebo sublingual drops

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type BIOLOGICAL

once daily intake of sublingual drops

Interventions

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Sublingual immunotherapy

once daily intake of sublingual drops

Intervention Type BIOLOGICAL

Placebo

once daily intake of sublingual drops

Intervention Type BIOLOGICAL

Other Intervention Names

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SLITone(TM) Birch

Eligibility Criteria

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Inclusion Criteria

* A history of birch pollen allergy
* Positive skin prick test to birch
* Positive conjunctival test to birch
* Positive specific Immunoglobulin E (IgE) to birch

Exclusion Criteria

* Forced expiratory volume in 1 second (FEV1)\<70% of predicted value
* History of seasonal allergy interfering with study
* History of symptomatic perennial allergy
* History of emergency visit or admission for asthma in the previous 12 month
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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ALK-Abelló A/S

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Hendrik Wolf, PhD

Role: STUDY_DIRECTOR

ALK-SCHERAX Arzneimittel GmbH

Margitta Worm, MD, Prof.

Role: PRINCIPAL_INVESTIGATOR

Charite University, Berlin, Germany

Locations

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Charité Klinik für Dermatologie, Venerologie und Allergologie

Berlin, State of Berlin, Germany

Site Status

Countries

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Germany

Other Identifiers

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SHX0712

Identifier Type: -

Identifier Source: org_study_id

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