Study to Determine the Effectiveness of Pillar Palatal Implants to Treat Obstructive Sleep Apnea

NCT ID: NCT00307957

Last Updated: 2007-12-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-10-31

Study Completion Date

2006-10-31

Brief Summary

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The Pillar palatal implant procedure is a minimally invasive and commercially available treatment for mild to moderate obstructive sleep apnea (OSA) in the United States and Europe. The implants are placed into the soft area in the roof of the mouth providing support to the soft palate. This research is being done to compare daytime sleepiness and sleep related quality of life after palatal implants.

Detailed Description

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Patients will be enrolled into the study based on sleep study results, a physical exam and inclusion/exclusion criteria. Once enrolled, patients are randomized into either the Pillar palatal implant group or a placebo/sham group.

In both cases, patients come into the office for placement of the implants. This is an outpatient procedure. Patients are followed at one week, one month and 3 months. At each follow-up visit, patients will undergo a physical exam and complete questionnaires related to sleep and quality of life. Patients will also undergo reaction time testing on hand-held device similar to a pocket video game. At the three month visit, patients will return to the sleep lab for another sleep study.

Conditions

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Obstructive Sleep Apnea

Keywords

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Obstructive Sleep Apnea Daytime Sleepiness Pillar Palatal Implants

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Interventions

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Pillar Palatal Implants

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* 18 years or older
* Body Mass Index equal to 32 or less
* Apnea-Hypopnea Index greater than/equal to 10 and less than/equal to 30
* Symptoms of daytime sleepiness

Exclusion Criteria

* Septal deviation or nasal obstruction
* Nasal polyps
* Severe seasonal allergies
* Soft palate length insufficient to accommodate implants
* Fujita Modified Mallampati Class 3
* Large tonsils
* Lingual tonsil hypertrophy
* Hypopharyngeal obstruction
* Previous pharyngeal surgery
* Previous upper respiratory tract cancer or radiation therapy
* Active respiratory tract infection
* Dysphagia or speech disorder
* Neurologic disorder
* Unstable psychiatric disorder
* Pregnant or breastfeeding
* History of falling asleep driving or MVA due to sleepiness
* Currently on CPAP therapy or other device for OSA
* Other sleep disorders
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Medtronic Xomed, Inc.

INDUSTRY

Sponsor Role collaborator

University of Cincinnati

OTHER

Sponsor Role lead

Principal Investigators

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David L Steward, MD

Role: PRINCIPAL_INVESTIGATOR

University Ear, Nose and Throat Specialists

Locations

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University of Indiana Medical Center

Indianapolis, Indiana, United States

Site Status

University Ear, Nose and Throat Specialists

Cincinnati, Ohio, United States

Site Status

Department of OTO-HNS Medical College of Wisconsin

Milwaukee, Wisconsin, United States

Site Status

Countries

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United States

Related Links

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http://www.restoremedical.com

Manufacturer's website for more information on Pillar Implants

Other Identifiers

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05-08-14-1

Identifier Type: -

Identifier Source: org_study_id