TRAUMEEL for Pain After Fracture of Neck of Femur

NCT ID: NCT00307905

Last Updated: 2010-10-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

PHASE3

Total Enrollment

224 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-01-31

Brief Summary

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We hypothesize that Traumeel S is more effective than placebo in reducing 48-hour mean cumulative morphine consumption in patients scheduled for surgical correction of fracture of neck of hip.

224 patients, meeting all inclusion and none of exclusion criteria, will be enrolled in the trial. Patients will be randomized to receive either intraoperative injection and post operative oral Traumeel S Tablets or placebo injection (normal saline) and indistinguishable oral placebo tablets. Baseline measurements of relevant outcome measures will taken preoperatively. Immediately after surgery, patients will receive an initial dose of morphine of 0.1mg/kg body weight. Patients will take the oral study medication for 21 days. Every four hours after surgery, patients will be asked to grade their pain on an NRS. Subsequent doses of morphine will be calculated based upon the patient's weight and current NRS, according to a preplanned scheme. Patients will be permitted to request additional morphine, beyond their calculated dose.

Detailed Description

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Conditions

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Pain Fracture of Neck of Femur

Keywords

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homeopathy pain traumeel s Fracture of neck of femur Surgical correction of fracture of neck of hip

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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A

TRAUMEEL S

Group Type ACTIVE_COMPARATOR

Traumeel S

Intervention Type DRUG

homeopathic remedy

B

placebo remedy

Group Type PLACEBO_COMPARATOR

Placebo remedy

Intervention Type DRUG

identical size, shape and taste of treatment medication

Interventions

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Traumeel S

homeopathic remedy

Intervention Type DRUG

Placebo remedy

identical size, shape and taste of treatment medication

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients of either sex undergoing surgical correction of unilateral fracture of neck of hip.
* Age over 18 years.
* Signature upon informed consent form

Exclusion Criteria

* Participation in another clinical trial within 4 weeks prior to enrollment.
* Refused to give verbal consent to the telephone interviews
* Impossibility to be reached during the 14-17 days post operative
* Inability to comply with the study protocol for any other reason
* Previous major surgical procedure on ipsilateral hip.
* Current use of analgesics for any other reason.
* A history of chronic pain syndrome.
* Abused legal or illicit drug use.
* Hypersensitivity to botanicals of the Compositae family
* Known sensitivity to paracetamol, codeine or tramadol.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shaare Zedek Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Shaare Zedek Medical Center,

Principal Investigators

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Menachem Oberbaum, MD

Role: PRINCIPAL_INVESTIGATOR

Shaare Zedek Medical Center, Jerusalem, Israel

Locations

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Dept. of Orthopedic Surgery, Shaare Zedek Medical Center

Jerusalem, , Israel

Site Status

Countries

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Israel

Other Identifiers

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NoF 06 CTIL

Identifier Type: -

Identifier Source: org_study_id