Effects of Ketamine On Precipitated Opioid Withdrawal Under General Anaesthesia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-02-28

Study Completion Date

2006-06-30

Brief Summary

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The purpose of this study is to determine whether low-dose ketamine infusion is effective in suppressing the symptoms of opiate withdrawal during rapid opiate antagonist induction (RAI).

Detailed Description

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Conditions

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Opiate Dependence

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Interventions

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Ketamine

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Diagnosed opiate dependence according to ICD 10 and/or DSM 4;
* Duration of substance abuse more than 1 year
* No or minor co-morbidities;
* Grade I-II according to physical status classification system of American Society of Anesthesiologists.

Exclusion Criteria

* Current history of long acting opiate or poly-substance abuse;
* Acute medical or surgical condition;
* Pregnancy;
* Breastfeeding.

Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Principal Investigators

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Juozas Ivaskevicius, Prof.

Role: STUDY_DIRECTOR

Vilnius University Clinic of Anaesthesiology and Intensive Care

Tomas Jovaisa, MD

Role: PRINCIPAL_INVESTIGATOR

Vilnius University Clinic of Anaesthesiology and Intensive Care

Locations

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Vilnius University Emergency Hospital

Vilnius, , Lithuania

Site Status

Countries

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Lithuania

References

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Ivaskevicius J, Jovaisa T, Laurinenas G, Vosylius S, Sipylaite J, Badaras R. [Safety and effectiveness of opiate antagonist detoxification under general anesthesia]. Medicina (Kaunas). 2005;41(12):1011-8. Lithuanian.

Reference Type RESULT

PMID: 16401957 (View on PubMed)

Jovaisa T, Laurinenas G, Vosylius S, Sipylaite J, Badaras R, Ivaskevicius J. Effects of ketamine on precipitated opiate withdrawal. Medicina (Kaunas). 2006;42(8):625-34.