To Determine The Amount Of Voriconazole In The Brain After 2 Loading Doses And 3 Maintenance Doses Over 3 Days

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-03-31

Study Completion Date

2008-08-31

Brief Summary

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To determine the amount of voriconazole in the brain after 2 loading doses and 3 maintenance doses over 3 days and compare it to the amount of voriconazole in the plasma.

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Detailed Description

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Conditions

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Infections, Fungal

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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voriconazole

voriconazole twice daily

Group Type EXPERIMENTAL

voriconazole

Intervention Type DRUG

Multiple oral doses of voriconazole at 400 mg loading twice daily followed by 200 mg maintenance twice daily

Interventions

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voriconazole

Multiple oral doses of voriconazole at 400 mg loading twice daily followed by 200 mg maintenance twice daily

Intervention Type DRUG

Other Intervention Names

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Vfend

Eligibility Criteria

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Inclusion Criteria

* Subjects must be willing and able to provide informed consent.
* Subjects must be willing and able to be confined at the Clinical Research Unit as required by the protocol.