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Oral Tolerance in Cow's Milk Allergy in the Infant

NCT ID: NCT00298376

Last Updated: 2007-04-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2006-03-31

Brief Summary

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This study aims to determine if there is a link between cow's milk allergy in infants and regulatory T cells dysfunction that should be transient in infant acquiring oral tolerance after 12 month avoiding food and persistent in others.

Cow's milk allergy is evaluated by basophils activation test, T cells activation test, specific humoral response (IgA, IgE, IgG) in allergic infants before and after 12 month avoiding food, before and after low dose milk exposure, before and after oral challenge.

Number and function of regulatory T cells and microflora composition are measured at the same time.

Allergic infants are compared to age matched control group.

Detailed Description

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Conditions

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Cow's Milk Allergy

Keywords

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Cow's milk allergy, food allergy oral tolerance, infant, regulatory T cells, intestinal microflora

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

male or female, age before 6 month, cow's milk allergy with positive prick or patch test for cow's milk

Control group: male or female, age before 6 month or within 12 and 18 month, eating cow's milk every day

Exclusion Criteria

immunodeficiency syndrome, lactose intolerance Control group: other food allergy, atopic dermatitis.
Minimum Eligible Age

1 Month

Maximum Eligible Age

15 Months

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Hospices Civils de Lyon

OTHER

Sponsor Role lead

Principal Investigators

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Alain LACHAUX, MD

Role: PRINCIPAL_INVESTIGATOR

Hospices Civils de Lyon

Locations

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Alain Lachaux

Lyon, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Florence VILLARD-TRUC, MD

Role: CONTACT

Phone: 33 472 110 390

Email: [email protected]

Dominique KAISERLIAN, PhD

Role: CONTACT

Email: [email protected]

Facility Contacts

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Alain LACHAUX, MD

Role: primary

Other Identifiers

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2005.389

Identifier Type: -

Identifier Source: org_study_id