Evaluation of a Mobile Cardiac Outpatient Telemetry System Versus Standard Loop Event Monitor

NCT ID: NCT00295204

Last Updated: 2006-08-03

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 300 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2005-04-30
• Study Completion Date: 2006-10-31

Brief Summary

Comparing the arrhythmia diagnostic yield of MCOT as compared to standard loop event monitors in patients presenting with palpitations, syncope or near syncope occurring less frequently than every 24 hours. Patients randomized and are enrolled for 30 days. Prior testing required: 24 hours of non diagnostic monitoring,

Detailed Description

Cardiac monitoring is used for diagnosing patient with symptoms. Holter monitoring or cardiac loop monitoring are the tests most ofter prescribed for patients depending on the frequency of symptoms. If the symptoms occur daily, a Holter may be prescribed, but when the symptoms become less frequent the diagnostic yield of Holter monitoring declines greatly. The current yields are approximately 5-10% depending on the indication. When the Holter is not longer an option for patients with infrequent symptoms a cardiac loop event monitor is prescribed to make a diagnosis. The yields on this monitoring also average approximately 25-35%. We feel that the yield on the Mobile Cardiac Ouptatient Telemetry (MCOT) service proviced by CardioNet is significantly higher due to the fact that every beat is analyzed using an algorithm and that many times the arrhythmia causing the symptoms has ended before the patient is able to press the button on the loop monitor to record the ECG. This study compares the MCOT service with Patients over 18 years of age experiencing syncope, near syncope or palpitations less frequently than daily. Require 24 hours of non-diagnostic ECG monitoring prior to randomization. Patients remain on monitoring for 30 days unless an arrhythmia diagnosis is made. The primary endpoint is confirmation of exclusion of a probable arrhythmic cause of pre-syncope, syncope or palpitations experienced by the subject prior to enrollment in the study. Secondary endpoints include time to diagnosis, time to detection of clinically significant arrhythmias, comparison of non-clinicaly significant arrhythmias, rate of asymptomatic arrhythmias both clinically and non clinically significant and a diagnosis related resource utilization. The study size is 300 subjects.

Conditions

Syncope; Pre-Syncope; Palpitations

Keywords

Syncope; pre-syncope; palpitations

Study Design

• Study Time Perspective: OTHER

Eligibility Criteria

Inclusion Criteria

• syncope, pre-syncope or palpitations less frequently than every 24 hours Pre-syncope without loss of consciousness defined as transient dizziness, leghtheadedness, unsteadiness or weak spells: syncopal events with or without warning: palpitations Subjects with non-diagnostic 24 hours of monitoring related to symptoms within 45 days of enrollment into study Subject able to understand, assent to , and willing to sign the Informed Consent Form.

Exclusion Criteria

• Class IV heart failure Post Myocardial infarction less than or equal to 3 months Unstable angina defined as chest pain at rest, new onset of angina, or a change in existing patterns of angina.

Subjects who are candidatees for or have had recent (less than or equal to 3 monthr) heart valve surgery History of sustained ventricualr tachycardia or ventricular fibrillation documented EF 35% or less with complex ectopy defined as PVC's 10 or greater per hour.

Subject is less than 18 years old at the time of signing informed consent. Any condition which may prohibit the completion of or compliance with the protocol.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Cardionet

INDUSTRY

Sponsor Role: lead

Principal Investigators

Stephen Rothman, MD

Role: PRINCIPAL_INVESTIGATOR

Mainline Arrhythmia and Cardiology Associates

Locations

Medicor Cardiology, PA

Bridgewater, New Jersey, United States

Garden State Cardiovascular Associates

Elizabeth, New Jersey, United States

Monmouth Cardiology Associates, LLC

Ocean City, New Jersey, United States

Cardiovascular Associates of NY

Flushing, New York, United States

Abington Medical Specialists

Abington, Pennsylvania, United States

Central Bucks Cardiology

Doylestown, Pennsylvania, United States

Central Bucks Specialitsts, LTD

Doylestown, Pennsylvania, United States

PA Heart and Vascular Group

Jenkintown, Pennsylvania, United States

Lancaster Heart and Stroke Foundation

Lancaster, Pennsylvania, United States

Southwestern PA Cardiology Associates

Pittsburgh, Pennsylvania, United States

Pottstown Medical Specialistsq

Pottstown, Pennsylvania, United States

Cardiology Consultants of Phladelphia

Yardley, Pennsylvania, United States

Virginia Cardiovascular Specialist

Richmond, Virginia, United States

Countries

United States

Other Identifiers

05-002

Identifier Type: -

Identifier Source: org_study_id