Moderate Alcohol Consumption, Risk of Cardiovascular Disease and Type 2 Diabetes: Influence of Alcohol Oxidation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-03-31

Study Completion Date

2006-06-30

Brief Summary

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Moderate alcohol consumption is associated with a decreased risk of cardiovascular disease and type 2 diabetes. The association of alcohol consumption with cardiovascular disease is mediated by a functional polymorphism of alcohol dehydrogenase 1c, but the effect of this polymorphism on alcohol metabolism is only investigated in vitro.

The risk reduction of moderate alcohol consumption for cardiovascular disease is explained largely by an increase of HDL cholesterol, but an increase of adiponectin concentrations after moderate alcohol consumption may also be involved. It seems likely that adiponectin is a mediator for the association of moderate alcohol consumption with type 2 diabetes. The mechanism by which moderate alcohol consumption increases adiponectin concentrations is unknown, but ppar-gamma activation may be involved.

effects of this polymorphism on mediators of this relation are not known. This study therefore investigates the effect of moderate alcohol consumption and the influence of alcohol dehydrogenase 1c polymorphism on ppar-gamma activated gene expression and risk factors of cardiovascular disease and type 2 diabetes.

Detailed Description

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Objectives :

To investigate the effect of moderate alcohol consumption and influence of genetic variation of ethanol oxidation on:

* PPAR-γ activated gene expression
* Markers of coronary heart disease or type 2 diabetes
* Postprandial changes of HPA-axis activity among 36 postmenopausal women with ADH1C genotype associated with slow or fast alcohol metabolism.

Design : Randomized, controlled, not blinded crossover trial with 1 week wash-out preceding each treatment period

Participants

* Description : Apparently healthy postmenopausal women
* Number : 36

Study substances

* Test substance : White wine (ca. 25 g alcohol/day)
* Reference substance : White grape juice

Study treatments Treatment A: 250 ml white wine daily (ca. 25 g alcohol/day) Treatment B: 250 ml white grape juice daily

Study period

\- Duration : two periods of 6 weeks preceded by 1 week wash-out period

Test parameters:

* Adiponectin mRNA expression
* Expression of PPAR-gamma activated genes: CD36, lipoprotein lipase, AP2
* Markers of cardiovascular disease (blood lipid profile, Lp-PLA2 activity, hs-CRP, fibrinogen)
* Markers of type 2 diabetes (adiponectin, adiponectin oligomers, insulin sensitivity)
* Parameters of alcohol oxidation (postprandial: blood alcohol and acetate, acetaldehyde)
* HPA-axis activity (postprandial \& fasting: cortisol, ACTH, testosterone)

Conditions

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Cardiovascular Disease Type 2 Diabetes

Keywords

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Moderate alcohol consumption Alcohol dehydrogenase 1c polymorphism PPAR-gamma activated gene expression

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Interventions

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Alcohol: 25 gday (white wine)

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Healthy women aged 40 to 65 years
* Absence of menstrual period for at least 2 years
* Homozygotes for the ADH1C\*1 or ADH1C\*2 allele of ADH1C I349V polymorphism
* Alcohol consumption ≥ 5 and ≤ 21 units/week

Exclusion Criteria

* Smoking
* Family history of alcoholism
* History of medical or surgical events that may significantly affect the study outcome, particularly metabolic or endocrine disorders and gastrointestinal disorders
* Recent blood donation

Minimum Eligible Age

40 Years

Maximum Eligible Age

65 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Principal Investigators

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Henk FJ Hendriks, PhD.

Role: PRINCIPAL_INVESTIGATOR

TNO

References

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Joosten MM, Schrieks IC, Hendriks HF. Effect of moderate alcohol consumption on fetuin-A levels in men and women: post-hoc analyses of three open-label randomized crossover trials. Diabetol Metab Syndr. 2014 Feb 18;6(1):24. doi: 10.1186/1758-5996-6-24.

Reference Type DERIVED

PMID: 24548643 (View on PubMed)

Joosten MM, Beulens JW, Kersten S, Hendriks HF. Moderate alcohol consumption increases insulin sensitivity and ADIPOQ expression in postmenopausal women: a randomised, crossover trial. Diabetologia. 2008 Aug;51(8):1375-81. doi: 10.1007/s00125-008-1031-y. Epub 2008 May 27.