High-Frequency Repetitive Transcranial Magnetic Stimulation Assists In Smoking Cessation
NCT ID: NCT00284219
Last Updated: 2011-06-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
50 participants
INTERVENTIONAL
2005-07-31
Brief Summary
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The mesolimbic dopaminergic reward system plays a crucial role in mediating the reinforcing effects of nicotine. Recently, acute high frequency repetitive transcranial magnetic stimulation (rTMS) of frontal brain regions has been shown to efficiently modulate the mesolimbic dopamine systems in both animals and humans. For this reason, we investigated whether 10 high-frequency (10Hz) rTMS treatments over the left dorsolateral prefrontal cortex can help people to withdraw smoking in comparison to placebo rTMS.
Smokers seeking to quit are recruited through newspaper advertisements. Participants were randomized to 10 days of either real or placebo high frequency rTMS.
Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Real high frequency rTMS
The patients will undergo a series of treatments of high frequency rTMS
Transcranial Magnetic Stimulation 10Hz
3\. rTMS subjects will receive 20 trains of rTMS at a rate of 10 Hz for 6 seconds (1200 pulses/session). Pulses will be administered over the left dorsolateral prefrontal cortex, defined as 5 cm anterior and in a parasagital plane to the point of maximum stimulation of the abductor pollicis muscle. Pulse intensity will be set at 100% motor threshold.
Sham high frequency rTMS
The patients will receive a series of sham treatments.
Magnetic stimulation using a special sham coil
Sham stimulation will be given at the same location as the active, with special sham coil.
Interventions
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Transcranial Magnetic Stimulation 10Hz
3\. rTMS subjects will receive 20 trains of rTMS at a rate of 10 Hz for 6 seconds (1200 pulses/session). Pulses will be administered over the left dorsolateral prefrontal cortex, defined as 5 cm anterior and in a parasagital plane to the point of maximum stimulation of the abductor pollicis muscle. Pulse intensity will be set at 100% motor threshold.
Magnetic stimulation using a special sham coil
Sham stimulation will be given at the same location as the active, with special sham coil.
Eligibility Criteria
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Exclusion Criteria
18 Years
65 Years
ALL
Yes
Sponsors
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Sheba Medical Center
OTHER_GOV
Responsible Party
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Sheba Medical Center
Principal Investigators
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Revital A Amiaz, MD
Role: PRINCIPAL_INVESTIGATOR
Sheba Medical Center
Abraham Zangen, Phd
Role: STUDY_DIRECTOR
Weizmann Institute of Science
Locations
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Sheba Medical Center
Ramat Gan, , Israel
Countries
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Other Identifiers
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SHEBA-04-3401-RA-CTIL
Identifier Type: -
Identifier Source: org_study_id