Study of Asenapine in Elderly Subjects With Psychosis (A7501021)(P05717)

NCT ID: NCT00281320

Last Updated: 2022-02-09

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

122 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-02-28

Study Completion Date

2008-12-31

Brief Summary

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This study evaluates the safety and tolerability of Asenapine in elderly patients with psychosis.

Detailed Description

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Conditions

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Psychosis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Asenapine 2-10 mg BID

Dose titration from 2 mg to 5 mg to 10 mg twice daily (BID)

Group Type EXPERIMENTAL

Asenapine

Intervention Type DRUG

Asenapine 2 mg twice daily (BID) on Days 1 and 2, 5 mg BID on Days 3 and 4, followed by 10 mg BID on Day 5 through the end of the trial (Week 6); or Asenapine 5 mg BID on Days 1 to 4 followed by 10 mg BID on Day 5 through the end of the trial (Week 6).

Asenapine 5-10mg BID

Dose titration from 5 mg to 10 mg BID

Group Type EXPERIMENTAL

Asenapine

Intervention Type DRUG

Asenapine 2 mg twice daily (BID) on Days 1 and 2, 5 mg BID on Days 3 and 4, followed by 10 mg BID on Day 5 through the end of the trial (Week 6); or Asenapine 5 mg BID on Days 1 to 4 followed by 10 mg BID on Day 5 through the end of the trial (Week 6).

Interventions

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Asenapine

Asenapine 2 mg twice daily (BID) on Days 1 and 2, 5 mg BID on Days 3 and 4, followed by 10 mg BID on Day 5 through the end of the trial (Week 6); or Asenapine 5 mg BID on Days 1 to 4 followed by 10 mg BID on Day 5 through the end of the trial (Week 6).

Intervention Type DRUG

Other Intervention Names

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Saphris

Eligibility Criteria

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Inclusion Criteria

* Elderly subjects with psychosis

Exclusion Criteria

* Have an uncontrolled, unstable clinically significant

medical condition.

* Have an established diagnosis of dementia
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Organon and Co

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

References

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Dubovsky SL, Frobose C, Phiri P, de Greef R, Panagides J. Short-term safety and pharmacokinetic profile of asenapine in older patients with psychosis. Int J Geriatr Psychiatry. 2012 May;27(5):472-82. doi: 10.1002/gps.2737. Epub 2011 Jul 13.

Reference Type RESULT
PMID: 21755540 (View on PubMed)

Other Identifiers

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A7501021

Identifier Type: -

Identifier Source: secondary_id

P05717

Identifier Type: -

Identifier Source: org_study_id

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