Prevention of Suicide in Primary Care Elderly: Collaborative Trial (PROSPECT)
NCT ID: NCT00279682
Last Updated: 2006-01-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
1200 participants
INTERVENTIONAL
1999-05-31
2003-08-31
Brief Summary
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Detailed Description
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The aim of the study was to determine the extent to which an intervention taht combined treatment guidelines with care management reduced rates of depression and suicide ideation in older primary care patients. The study randomized 20 primary care practices from New York City, Philadelphia, and Pittsburgh regions into intervention or usual car. The used a two-stage sampling design that resulted in a representative sample with an oversample of depressed patients (total n=1238 subjects including 598 with a depression diagnosis and 640 with no depression diagnosis). Patients were assessed at baseline, 4, 8, 12, 18 and 24 months.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
NONE
Interventions
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treatment guidelines and depression care management
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* minimental status examination \<18
* ability to communicate in English
60 Years
ALL
Yes
Sponsors
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University of Pennsylvania
OTHER
University of Pittsburgh
OTHER
National Institute of Mental Health (NIMH)
NIH
Forest Laboratories
INDUSTRY
The John A. Hartford Foundation
OTHER
Weill Medical College of Cornell University
OTHER
Principal Investigators
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George S Alexopoulos, MD
Role: PRINCIPAL_INVESTIGATOR
Weill Medical College of Cornell University
Ira Katz, MD. Ph.D.
Role: PRINCIPAL_INVESTIGATOR
University of Pennsylvania
Charles F Reynolds, MD
Role: PRINCIPAL_INVESTIGATOR
University of Pittsburgh
Locations
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Weill Medical College of Cornell University
White Plains, New York, United States
Universilty of Pennsylvania
Philadelphia, Pennsylvania, United States
University of Pittsburgh
Pittsburgh, Pennsylvania, United States
Countries
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References
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Bruce ML, Pearson JL. Designing an intervention to prevent suicide: PROSPECT (Prevention of Suicide in Primary Care Elderly: Collaborative Trial). Dialogues Clin Neurosci. 1999 Sep;1(2):100-12. doi: 10.31887/DCNS.1999.1.2/mbruce.
Bruce ML, Ten Have TR, Reynolds CF 3rd, Katz II, Schulberg HC, Mulsant BH, Brown GK, McAvay GJ, Pearson JL, Alexopoulos GS. Reducing suicidal ideation and depressive symptoms in depressed older primary care patients: a randomized controlled trial. JAMA. 2004 Mar 3;291(9):1081-91. doi: 10.1001/jama.291.9.1081.
Alexopoulos GS, Katz IR, Bruce ML, Heo M, Ten Have T, Raue P, Bogner HR, Schulberg HC, Mulsant BH, Reynolds CF 3rd; PROSPECT Group. Remission in depressed geriatric primary care patients: a report from the PROSPECT study. Am J Psychiatry. 2005 Apr;162(4):718-24. doi: 10.1176/appi.ajp.162.4.718.
Gallo JJ, Bogner HR, Morales KH, Post EP, Ten Have T, Bruce ML. Depression, cardiovascular disease, diabetes, and two-year mortality among older, primary-care patients. Am J Geriatr Psychiatry. 2005 Sep;13(9):748-55. doi: 10.1176/appi.ajgp.13.9.748.
Gallo JJ, Hwang S, Truong C, Reynolds CF, Spira AP. Role of persistent and worsening sleep disturbance in depression remission and suicidal ideation among older primary care patients: the PROSPECT study. Sleep. 2020 Oct 13;43(10):zsaa063. doi: 10.1093/sleep/zsaa063.
Gilman SE, Fitzmaurice GM, Bruce ML, Ten Have T, Glymour MM, Carliner H, Alexopoulos GS, Mulsant BH, Reynolds CF 3rd, Cohen A. Economic inequalities in the effectiveness of a primary care intervention for depression and suicidal ideation. Epidemiology. 2013 Jan;24(1):14-22. doi: 10.1097/EDE.0b013e3182762403.
Bao Y, Alexopoulos GS, Casalino LP, Ten Have TR, Donohue JM, Post EP, Schackman BR, Bruce ML. Collaborative depression care management and disparities in depression treatment and outcomes. Arch Gen Psychiatry. 2011 Jun;68(6):627-36. doi: 10.1001/archgenpsychiatry.2011.55.
Alexopoulos GS, Reynolds CF 3rd, Bruce ML, Katz IR, Raue PJ, Mulsant BH, Oslin DW, Ten Have T; PROSPECT Group. Reducing suicidal ideation and depression in older primary care patients: 24-month outcomes of the PROSPECT study. Am J Psychiatry. 2009 Aug;166(8):882-90. doi: 10.1176/appi.ajp.2009.08121779. Epub 2009 Jun 15.
Other Identifiers
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