Estimating the Incidence of HIV Infection Among Men Who Have Sex With Men in Peru and Ecuador

NCT ID: NCT00279331

Last Updated: 2013-09-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

2608 participants

Study Classification

OBSERVATIONAL

Study Completion Date

2006-11-30

Brief Summary

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The purpose of this observational study is to estimate the number of new HIV infections and the number and variability of antiretroviral-resistant HIV strains among men who have sex with men (MSM). Participants will be recruited from four sites in Peru and one site in Ecuador.

Detailed Description

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The governments of Peru and Ecuador signed an agreement with the Global Fund to Fight AIDS, Tuberculosis, and Malaria to help guarantee comprehensive quality of care to people living with HIV, including access to antiretrovirals (ARVs). Current methods of surveillance are inadequate in estimating the true burden of disease. Broad access to ARVs in countries without regular drug resistance testing can also cause rapid development of ARV resistance. By establishing a more sophisticated surveillance system able to capture HIV incidence, prevalence, patterns of HIV resistance, and genetic variability of viral strains, Peru and Ecuador will be better equipped to monitor the HIV epidemic, develop personalized prevention and control measures, and track patterns of HIV resistance among infected patients. This study will estimate the incidence of HIV, syphilis, and herpes simplex virus 2 (HSV-2) among MSM in Peru and Ecuador, as well as examine the number and variability of ARV-resistant HIV strains.

This study will last about 2 weeks. Medical history, a physical exam, an HIV rapid test, and HIV pre- and post-test counseling will occur at study entry. Those who test HIV positive will be asked to return to the test site in about 2 weeks to receive confirmatory test results. Patients confirmed to be infected with HIV will be referred to HIV treatment clinics in their area.

At study entry, participants will also undergo a syphilis test. Those who test positive for syphilis will receive same-day treatment at the clinic and be asked to return during Week 1 and 2 to complete treatment for sexually transmitted diseases (STDs) according to local guidelines. STD treatment will not be provided by the study. Those who test negative to both the HIV rapid test and the syphilis test at screening will not participate in any more study visits. Patients who consent to having samples stored for further investigations will also have their samples tested for HSV-2 infection following completion of the study.

Conditions

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HIV Infections Syphilis Sexually Transmitted Diseases

Keywords

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HIV Seronegativity Men who have Sex with Men MSM Peru Ecuador Incidence Prevalence Drug resistance, viral

Study Design

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Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* HIV uninfected or unaware of HIV infection status
* Male at birth
* Report having anal intercourse, either insertive or receptive, with another man 6 months prior to study entry
* Living in one of the participating study cities at time of study entry
* Self-report at least one of the following behaviors:

* No condom use during the last receptive or insertive anal intercourse
* Receptive or insertive anal intercourse with more than five sex partners 6 months prior to study entry
* Exchange of money, gifts, drugs, or shelter for sex 6 months prior to study entry
* STD symptoms 6 months prior to study entry
* Inconsistent condom use with an HIV infected sex partner 6 months prior to study entry

Exclusion Criteria

* HIV infected
* Unwilling to participate in HIV screening
* Any psychiatric or mental condition that may interfere with the study
Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Comprehensive International Program of Research on AIDS

OTHER

Sponsor Role collaborator

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Juan Guanira, MD, MPH

Role: STUDY_CHAIR

Asociación Civil Impacta Salud y Educación, Lima, Peru

Jorge Sanchez, MD, MPH

Role: PRINCIPAL_INVESTIGATOR

Asociación Civil Impacta Salud y Educación, Lima, Peru

Javier R. Lama, MD, MPH

Role: PRINCIPAL_INVESTIGATOR

Asociación Civil Impacta Salud y Educación, Lima, Peru

Locations

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Fundación Ecuatoriana Equidad CIPRA CRS

Guayaquil-Guayas, , Ecuador

Site Status

IMPACTA - Miraflores CIPRA CRS

Lima, , Peru

Site Status

IMPACTA - Lince CIPRA CRS

Lima, , Peru

Site Status

IMPACTA - San Miguel CIPRA Project 3B CRS

Lima, , Peru

Site Status

Policlinico Daniel Alcides Carrión CIPRA CRS

Lima, , Peru

Site Status

Asoc. de Servicios Generales de Salud y Educación CIPRA CRS

Sullana, , Peru

Site Status

Countries

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Ecuador Peru

References

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Bautista CT, Sanchez JL, Montano SM, Laguna-Torres VA, Lama JR, Sanchez JL, Kusunoki L, Manrique H, Acosta J, Montoya O, Tambare AM, Avila MM, Vinoles J, Aguayo N, Olson JG, Carr JK. Seroprevalence of and risk factors for HIV-1 infection among South American men who have sex with men. Sex Transm Infect. 2004 Dec;80(6):498-504. doi: 10.1136/sti.2004.013094.

Reference Type BACKGROUND
PMID: 15572623 (View on PubMed)

Caceres CF, Mendoza W. Monitoring trends in sexual behaviour and HIV/STIs in Peru: are available data sufficient? Sex Transm Infect. 2004 Dec;80 Suppl 2(Suppl 2):ii80-4. doi: 10.1136/sti.2004.012021.

Reference Type BACKGROUND
PMID: 15572646 (View on PubMed)

Goodreau SM, Goicochea LP, Sanchez J. Sexual role and transmission of HIV Type 1 among men who have sex with men, in Peru. J Infect Dis. 2005 Feb 1;191 Suppl 1(0 1):S147-58. doi: 10.1086/425268.

Reference Type BACKGROUND
PMID: 15627225 (View on PubMed)

Hirsch MS, Brun-Vezinet F, Clotet B, Conway B, Kuritzkes DR, D'Aquila RT, Demeter LM, Hammer SM, Johnson VA, Loveday C, Mellors JW, Jacobsen DM, Richman DD. Antiretroviral drug resistance testing in adults infected with human immunodeficiency virus type 1: 2003 recommendations of an International AIDS Society-USA Panel. Clin Infect Dis. 2003 Jul 1;37(1):113-28. doi: 10.1086/375597. Epub 2003 Jun 23.

Reference Type BACKGROUND
PMID: 12830416 (View on PubMed)

Other Identifiers

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I-U19-AI053218-01A2

Identifier Type: -

Identifier Source: secondary_id

Project 3B

Identifier Type: -

Identifier Source: secondary_id

10408

Identifier Type: REGISTRY

Identifier Source: secondary_id

CIPRA PE 002

Identifier Type: -

Identifier Source: org_study_id