High-Resolution Ultrasound Imaging of the Retina and Choroid for Detection on Age Related Macular Degeneration

NCT ID: NCT00277784

Last Updated: 2008-03-07

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 40 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2005-07-31
• Study Completion Date: 2006-06-30

Brief Summary

The macula is the site of central vision within the retina. The retina is oxygenated by the underlying choroid. These tissues are less than 1 mm thick in total. While optical techniques can reveal much about the structure of the retina, ultrasound allows imaging of the choroid and deeper tissues. This study will investigate use of high frequency (20 MHz) ultrasound for imaging of the retina and choroid in patients with age-related macular degeneration, a prime cause of blindness. The investigation will involve use of novel post-processing methodologies to achieve maximum resolution of the fine tissue structures involved in this disease.

Detailed Description

Age-related macular degeneration (AMD), a condition affecting over 40% of individuals 70 years or age or more, causes progressive loss of central vision. Photocoagulation has long been used to slow the progress of AMD, but new vision-preserving methods are currently under investigation. Because destroyed photoreceptors are permanently lost, early management is essential for preservation of vision. The aim of this project will be to study AMD using a suite of new high-resolution ultrasound imaging techniques that have been developed. Specifically, high-resolution ultrasound will be used to generate images of the retina and choroid, including perfusion measurements using slow-flow methods developed by our research group. Ultrasound studies will be performed in conjunction with optical coherence tomography (OCT) imaging in a series of patients and age-matched control subjects with the aim of determining if choroidal thickness and/or perfusion might be used as an early indicator of AMD and thus aid in patient management.

We will study 20 subjects diagnosed with AMD. We will attempt to have an approximately equal number of subjects with wet and dry forms of AMD. A control group consisting of 20 non-AMD age-matched subjects will also be recruited. Ultrasound scan sequences will consist of B-mode images of the macula and surrounding tissues.

Conditions

Age Related Macular Degeneration

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: PROSPECTIVE

Study Groups

1

Individuals with age related macular degeneration

Ultrasound examination

Intervention Type: PROCEDURE

one ultrasound examination

Interventions

Ultrasound examination

one ultrasound examination

Intervention Type: PROCEDURE

Other Intervention Names

High Frequency Ultrasound

Eligibility Criteria

Inclusion Criteria

Age related macular degeneration age matched control

Exclusion Criteria

none

• Minimum Eligible Age: 45 Years
• Maximum Eligible Age: 90 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Weill Medical College of Cornell University

OTHER

Sponsor Role: lead

Responsible Party

Weill Cornell Medical College

Principal Investigators

Ronald H Silverman, PhD

Role: PRINCIPAL_INVESTIGATOR

Weill Medical College of Cornell University

D. Jackson Coleman, MD

Role: STUDY_CHAIR

Weill Cornell Medical College - New York Presbyterian Hospital

Locations

Weill Cornell Medical College

New York, New York, United States

Countries

United States

References

Silverman RH. Ultrasound versus AC OCT. J Cataract Refract Surg. 2005 Aug;31(8):1475; author reply 1475-7. doi: 10.1016/j.jcrs.2005.08.011. No abstract available.

Reference Type: BACKGROUND

PMID: 16129261 (View on PubMed)

Coleman DJ, Silverman RH, Chabi A, Rondeau MJ, Shung KK, Cannata J, Lincoff H. High-resolution ultrasonic imaging of the posterior segment. Ophthalmology. 2004 Jul;111(7):1344-51. doi: 10.1016/j.ophtha.2003.10.029.

Reference Type: BACKGROUND

PMID: 15234135 (View on PubMed)

Coleman DJ, Silverman RH, Rondeau MJ, Lloyd HO, Khanifar AA, Chan RV. Age-related macular degeneration: choroidal ischaemia? Br J Ophthalmol. 2013 Aug;97(8):1020-3. doi: 10.1136/bjophthalmol-2013-303143. Epub 2013 Jun 5.

Reference Type: DERIVED

PMID: 23740965 (View on PubMed)

Other Identifiers

AIUM #1-2005

Identifier Type: -

Identifier Source: org_study_id