Combination Chemotherapy, Total-Body Irradiation, and Alemtuzumab in Treating Patients Undergoing an Autologous Stem Cell Transplant for Stage I, Stage II, Stage III, or Stage IV Chronic Lymphocytic Leukemia

NCT ID: NCT00276809

Last Updated: 2016-09-26

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 30 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2001-06-30
• Study Completion Date: 2004-09-30

Brief Summary

RATIONALE: Giving combination chemotherapy before a peripheral blood stem cell transplant stops the growth of cancer cells by stopping them from dividing or killing them. Giving colony-stimulating factors, such as G-CSF, and certain chemotherapy drugs, helps stem cells move from the bone marrow to the blood so they can be collected and stored. A monoclonal antibody, such as alemtuzumab, is given to kill any remaining cancer cells. Chemotherapy and radiation therapy (total-body irradiation) are given to prepare the bone marrow for the stem cell transplant. The stem cells are then returned to the patient to replace the blood-forming cells that were destroyed by the chemotherapy and radiation therapy. Giving combination chemotherapy, total-body irradiation, and alemtuzumab together with autologous peripheral stem cell transplant may kill more cancer cells.

PURPOSE: This phase II trial is studying how well giving combination chemotherapy together with total-body irradiation and alemtuzumab works in treating patients undergoing an autologous stem cell transplant for stage I, stage II, stage III, or stage IV chronic lymphocytic leukemia.

Detailed Description

OBJECTIVES:

Primary

• Determine the safety and feasibility of cytoreductive fludarabine and cyclophosphamide followed by high-dose myeloablative therapy comprising total-body irradiation, cyclophosphamide, and alemtuzumab in patients undergoing autologous filgrastim (G-CSF)-mobilized peripheral blood stem cell transplantation for stage I-IV chronic lymphocytic leukemia.

Secondary

• Determine the clinical and molecular remission rate and duration in patients treated with this regimen.
• Determine the overall survival of patients treated with this regimen.

OUTLINE: This is a multicenter, open label, nonrandomized study. Patients are assigned to 1 of 2 cohorts according to time of enrollment.

• Cytoreductive induction therapy: All patients receive fludarabine IV and cyclophosphamide IV on days 1-3. Treatment repeats every 28 days for 2-4 courses in the absence of disease progression or unacceptable toxicity. Patients achieving complete response (CR) or partial response (PR) proceed to stem cell mobilization. Patients with stage III or IV disease at this point are removed from study.
• Stem cell mobilization: All patients receive Dexa-BEAM comprising oral dexamethasone once daily on days 1-10; carmustine IV and melphalan IV on day 2; and cytarabine IV twice daily and etoposide IV once daily on days 4-7. Patients also receive filgrastim (G-CSF) subcutaneously beginning on day 8 and continuing until leukapheresis is completed. Patients undergo peripheral blood stem cell (PBSC) harvest between days 20 and 28. Patients without an adequate number of collected PBSCs may receive a second course of Dexa-BEAM. Patients achieving CR or very good PR proceed to high-dose myeloablative therapy and PBSC transplantation (PBSCT) with or without consolidation therapy.
• Consolidation therapy: Beginning between 1-2 months after completion of Dexa-BEAM, patients in cohort 2 receive alemtuzumab IV over 2 hours on days 1, 3, 5, 8, 10, 12, 15, 17, 19, 22, 24, and 26 and then proceed to high-dose myeloablative therapy and PBSCT within 1 month after completion of consolidation therapy. Patients in cohort 1 do not receive consolidation therapy and proceed directly to high-dose therapy within 3 months after completion of stem cell mobilization.
• High-dose myeloablative therapy and PBSCT: Patients undergo total-body irradiation on days -7 to -5. Patients then receive cyclophosphamide IV on days -4 and -3 and alemtuzumab IV over 2 hours on days -10, -9, -8, -6, and -4. Patients undergo PBSCT on day 0.

After completion of study treatment, patients are followed periodically.

PROJECTED ACCRUAL: A total of 30 patients will be accrued for this study.

Conditions

Chronic Lymphocytic Leukemia

Study Design

• Allocation Method: NON_RANDOMIZED
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Interventions

alemtuzumab

Intervention Type: BIOLOGICAL

filgrastim

Intervention Type: BIOLOGICAL

carmustine

Intervention Type: DRUG

cyclophosphamide

Intervention Type: DRUG

cytarabine

Intervention Type: DRUG

dexamethasone

Intervention Type: DRUG

etoposide

Intervention Type: DRUG

fludarabine phosphate

Intervention Type: DRUG

melphalan

Intervention Type: DRUG

autologous bone marrow transplantation

Intervention Type: PROCEDURE

peripheral blood stem cell transplantation

Intervention Type: PROCEDURE

radiation therapy

Intervention Type: RADIATION

Eligibility Criteria

Inclusion Criteria

DISEASE CHARACTERISTICS:

• Chronic lymphocytic leukemia (CLL), meeting 1 of the following stage criteria:

• Stage I-IV disease
• Binet stage B or C disease
• Binet stage A disease at high risk for rapid disease progression, as defined by both of the following criteria:

• Nonnodular marrow infiltration and/or lymphocyte doubling time < 12 months
• Thymidine kinase > 7.0 U/L and/or ß-2-microglobulin > 3.5 mg/L
• Polymerase chain reaction-amplifiable clonal CDR III rearrangement of the immunoglobulin variable heavy chain gene
• No Richter's syndrome or B-prolymphocytic leukemia

PATIENT CHARACTERISTICS:

• ECOG performance status 0-1
• No concurrent disease resulting in major organ dysfunction
• Not pregnant or nursing
• Fertile patients must use effective contraception
• No other concurrent malignancy
• No New York Heart Association class III or IV cardiac failure
• No cardiomyopathy
• No history of myocardial infarction
• No symptomatic coronary heart disease
• No severe cardiac arrhythmia
• No severe or uncontrolled hypertension
• No chronic pulmonary disease
• No pulmonary function test impairment
• No severe or uncontrolled diabetes mellitus
• Bilirubin or transaminases ≤ 1.5 times upper limit of normal
• Creatinine ≤ 1.4 mg/dL
• No cerebral dysfunction
• No severe psychiatric impairment
• No drug addiction or alcoholism
• Negative HIV
• Negative Hepatitis B or C
• No allergy to any of the protocol drugs
• No history of anaphylactic reaction to monoclonal antibodies
• No active infection

PRIOR CONCURRENT THERAPY:

• No more than 1 prior chemotherapy regimen OR chemotherapy that lasted > 6 months
• No prior radiotherapy
• No prior treatment with alemtuzumab
• No prior long-term (> 1 month) systemic corticosteroids
• No prior therapy with dexamethasone, carmustine, etoposide, cytarabine, and melphalan (Dexa-BEAM)

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

German CLL Study Group

OTHER

Sponsor Role: lead

Principal Investigators

Stephan Stilgenbauer, MD

Role: STUDY_CHAIR

Comprehensive Cancer Center Ulm at Universitaetsklinikum Ulm

Locations

Charite - Universitaetsmedizin Berlin - Campus Benjamin Franklin

Berlin, , Germany

Universitaetsklinikum Essen

Essen, , Germany

Asklepios Klinik St. Georg

Hamburg, , Germany

Medizinische Hochschule Hannover

Hanover, , Germany

Universitatsklinikum Heidelberg

Heidelberg, , Germany

Staedtisches Klinikum Karlsruhe gGmbH

Karlsruhe, , Germany

University Hospital Schleswig-Holstein - Kiel Campus

Kiel, , Germany

Universitaetsklinkum Magdeburg der Otto-von-Guericke-Universitaet Magdeburg

Magdeburg, , Germany

Universitatsklinik Mainz

Mainz, , Germany

Klinikum der Universitaet Muenchen - Grosshadern Campus

Munich, , Germany

Klinikum Rechts Der Isar - Technische Universitaet Muenchen

Munich, , Germany

Comprehensive Cancer Center Ulm at Universitaetsklinikum Ulm

Ulm, , Germany

Countries

Germany

Related Links

http://www.dcllsg.de

German CLL Study Group

Other Identifiers

EU-20556

Identifier Type: -

Identifier Source: secondary_id

MEDAC-GCLLSG-CLL3C

Identifier Type: -

Identifier Source: secondary_id

CLL3C

Identifier Type: -

Identifier Source: org_study_id