Treatment Resistant Bipolar Depression

NCT ID: NCT00272025

Last Updated: 2015-12-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE1

Total Enrollment

1 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-10-31

Study Completion Date

2010-01-31

Brief Summary

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To determine if adding Escitalopram to current mood stabilizer (MS) or atypical antipsychotic (AA) will improve in rates similar to or better than adding a placebo (inactive pill)in resistant bipolar patients.

Detailed Description

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Conditions

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Bipolar Depression

Keywords

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Bipolar Depression Escitalopram Mood Stabilizer Atypical Antipsychotic

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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1

There is a 50% chance of being randomized to Escitalopram in addition to current atypical antipsychotic (minimum dose risperidone 3mg, olanzapine 10mg or seroquel 400mg) or mood stabilizer (lithium, epival or lamotrigine)

Group Type ACTIVE_COMPARATOR

Escitalopram

Intervention Type DRUG

10mg to 20mg tablet daily for 6 weeks

2

to be filled in

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type DRUG

Interventions

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Escitalopram

10mg to 20mg tablet daily for 6 weeks

Intervention Type DRUG

placebo

Intervention Type DRUG

Other Intervention Names

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Cipralex

Eligibility Criteria

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Inclusion Criteria

* Age 18 or older
* Diagnosis of Bipolar Disorder and currently be in depressive state, and not responded to mood stabilizer or atypical antipsychotic alone or combined with an antidepressant medication.

Exclusion Criteria

* Pregnant or breastfeeding
* History of seizure disorder or other unstable medical condition
* Received Electroconvulsive Therapy or Transcranial Magnetic Stimulation in the last three months
* Experienced hallucinations or delusions
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Queen's University

OTHER

Sponsor Role lead

Responsible Party

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Dr. Roumen Milev

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Roumen V. Milev, MD

Role: PRINCIPAL_INVESTIGATOR

Queen's University

Locations

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Providence Care, Mental Health Services

Kingston, Ontario, Canada

Site Status

Countries

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Canada

Other Identifiers

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PSIY-207-05

Identifier Type: -

Identifier Source: org_study_id