Implementation Strategies for a Simple Intervention to Reduce Longterm Benzodiazepine Use in Dutch Community Pharmacies
NCT ID: NCT00268775
Last Updated: 2009-08-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
20000 participants
INTERVENTIONAL
2005-11-30
2006-12-31
Brief Summary
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Detailed Description
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One of the subjects to which attention is paid in community pharmacies, is the undesirable long-term use of benzodiazepines. Treatment methods for discontinuation of long-term benzodiazepine use have been studied rather extensively. A simple patient-directed discontinuation letter proved to be effective in several studies.
Comparison: a minimal intervention group (pharmacists carrying out the intervention guided by a manual only) compared to a maximal intervention group (pharmacists receiving a manual, a training aimed at better cooperation and communication with family practitioners and some support in the management of the project).
Conditions
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Study Design
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RANDOMIZED
SINGLE_GROUP
NONE
Interventions
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training and follow-up of pharmacists
patient-directed discontinuation letter
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
ALL
No
Sponsors
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Zorgverzekeraar CZ
OTHER
Scientific Institute for Dutch Pharmacists, The Netherlands
OTHER
Radboud University Medical Center
OTHER
Principal Investigators
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Peter G de Smet, PhD
Role: PRINCIPAL_INVESTIGATOR
Scientific Institute for Dutch Pharmacists, The Netherlands
Michel Wensing, PhD
Role: STUDY_DIRECTOR
Centre for Quality of Care Research Nijmegen
Locations
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Apotheek Schellekens
's-Hertogenbosch, , Netherlands
Apotheek Cleij
's-Hertogenbosch, , Netherlands
Apotheek Empel
's-Hertogenbosch, , Netherlands
Apotheek Asten
Asten, , Netherlands
Apotheek Bakel-Milheeze
Bakel, , Netherlands
Kring-apotheek Bergeyk
Bergeijk, , Netherlands
Apotheek Berlicum
Berlicum, , Netherlands
Lloyds Apotheek van Kollenburg
Best, , Netherlands
Apotheek de Schakel
Best, , Netherlands
Apotheek Heivelden
Best, , Netherlands
Apotheek Blanckenburgh
Beuningen, , Netherlands
Apotheek Bladel
Bladel, , Netherlands
Apotheek Bocholtz
Bocholtz, , Netherlands
Apotheek van de Wouw
Brunssum, , Netherlands
Apotheek Budel
Budel, , Netherlands
Apotheek in 't Groen
Deurne, , Netherlands
Apotheek Koolen-Motké
Deurne, , Netherlands
Apotheek de Schelde
Deurne, , Netherlands
Apotheek Druten
Druten, , Netherlands
Apotheek de Kempen
Eersel, , Netherlands
Apotheek Elsloo
Elsloo, , Netherlands
Apotheek Ewijk
Ewijk, , Netherlands
Apotheek Eygelshoven
Eygelshoven, , Netherlands
Lloyds Apotheek Geldrop
Geldrop, , Netherlands
Apotheek het Frans Brugske
Gemert, , Netherlands
Apotheek Lindner
Gemert, , Netherlands
Apotheek de Duivenakker
Gennep, , Netherlands
Apotheek Gennep
Gennep, , Netherlands
Apotheek de Pijlers
Goes, , Netherlands
Zeeuwse Apotheek
Goes, , Netherlands
Apotheek de Goese Polder
Goes, , Netherlands
Apotheek Groesbeek
Groesbeek, , Netherlands
Linde apotheek
Hapert, , Netherlands
Apotheek Heeswijk-Dinther
Heeswijk-Dinther, , Netherlands
Apotheek Tendijck
Helmond, , Netherlands
Service Apotheek de Bus
Helmond, , Netherlands
Service apotheek Vondellaan
Helmond, , Netherlands
Apotheek de Luifel
Helmond, , Netherlands
Apotheek Brouwhuis
Helmond, , Netherlands
Kring-apotheek de Rijpel
Helmond, , Netherlands
Lloyds Apotheek Herkenbosch
Herkenbosch, , Netherlands
Apotheek Hegtermans
Herten, , Netherlands
Apotheek Herten-Merum
Herten, , Netherlands
apotheek Kerkrade-centrum
Kerkrade, , Netherlands
Apotheek Schonefeld
Kerkrade, , Netherlands
Apotheek Bleijerheide
Kerkrade, , Netherlands
Apotheek Medische Centrum West Kerkrade
Kerkrade, , Netherlands
Apotheek Terwinselen
Kerkrade, , Netherlands
Apotheek Waubach
Landgraaf, , Netherlands
Apotheek Landgraaf
Landgraaf, , Netherlands
Apotheek MC Putstraat
Landgraaf, , Netherlands
Apotheek Schaesberg
Landgraaf, , Netherlands
Apotheek Nieuwenhagen
Landgraaf, , Netherlands
Apotheek Maarheeze
Maarheeze, , Netherlands
Apotheek Craveld
Maasbracht, , Netherlands
Apotheek Maasbracht
Maasbracht, , Netherlands
Service apotheek Malden
Malden, , Netherlands
Apotheek Maasdorpen
Meerlo, , Netherlands
Lloyds Apotheek de Roerstreek
Melick, , Netherlands
Apotheek Ringeling
Middelburg, , Netherlands
Apotheek Hummelen
Middelburg, , Netherlands
Apotheek Stromenwijk 't Zand
Middelburg, , Netherlands
Apotheek Welsinge
Middelburg, , Netherlands
Apotheek Dauwendaele
Middelburg, , Netherlands
Apotheek van der Ploeg
Nijmegen, , Netherlands
Kring-apotheek Beckers
Nijmegen, , Netherlands
Apotheek Souburg
Oost-Souburg, , Netherlands
Lloyds Apotheek Postert
Posterholt, , Netherlands
Apotheek Reusel
Reusel, , Netherlands
Lloyds Apotheek Clemens-Haan
Roermond, , Netherlands
Reinald apotheek
Roermond, , Netherlands
Apotheek Hendrickx-Maasniel
Roermond, , Netherlands
Lloyds Apotheek Donderberg
Roermond, , Netherlands
Apotheek Roermond Zuid
Roermond, , Netherlands
Apotheek Rosmalen-Walschot
Rosmalen, , Netherlands
Apotheek Rosmalen
Rosmalen, , Netherlands
apotheek Simpelveld-Bocholtz
Simpelveld, , Netherlands
Apotheek Hopveld
Sint-Michielsgestel, , Netherlands
Apotheek de Baandert
Sittard, , Netherlands
Wandelbos Apotheek
Tilburg, , Netherlands
Apotheek de Belleman
Valkenswaard, , Netherlands
Apotheek Valkenswaard
Valkenswaard, , Netherlands
Apotheek Vlaslant
Valkenswaard, , Netherlands
Apotheek Dommeldal
Valkenswaard, , Netherlands
apotheek 't Zuid
Veghel, , Netherlands
Veldhovense Apotheek
Veldhoven, , Netherlands
Apotheek Zonderwijk
Veldhoven, , Netherlands
Apotheek van Poppel
Wijchen, , Netherlands
Apotheek Dr. H. Kilian
Wijchen, , Netherlands
Apotheek Wijchen-Zuid
Wijchen, , Netherlands
Countries
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References
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Odedina FT, Hepler CD, Segal R, Miller D. The Pharmacists' Implementation of Pharmaceutical Care (PIPC) model. Pharm Res. 1997 Feb;14(2):135-44. doi: 10.1023/a:1012032223328.
Anderson GM, Lexchin J. Strategies for improving prescribing practice. CMAJ. 1996 Apr 1;154(7):1013-7.
Grimshaw JM, Shirran L, Thomas R, Mowatt G, Fraser C, Bero L, Grilli R, Harvey E, Oxman A, O'Brien MA. Changing provider behavior: an overview of systematic reviews of interventions. Med Care. 2001 Aug;39(8 Suppl 2):II2-45.
Collins TM, Mott DA, Bigelow WE, Zimmerman DR. A controlled letter intervention to change prescribing behavior: results of a dual-targeted approach. Health Serv Res. 1997 Oct;32(4):471-89.
Muijrers PE, Knottnerus JA, Sijbrandij J, Janknegt R, Grol RP. Changing relationships: attitudes and opinions of general practitioners and pharmacists regarding the role of the community pharmacist. Pharm World Sci. 2003 Oct;25(5):235-41. doi: 10.1023/a:1025872907411.
Zitman FG, Couvee JE. Chronic benzodiazepine use in general practice patients with depression: an evaluation of controlled treatment and taper-off: report on behalf of the Dutch Chronic Benzodiazepine Working Group. Br J Psychiatry. 2001 Apr;178:317-24. doi: 10.1192/bjp.178.4.317.
Vorma H, Naukkarinen H, Sarna S, Kuoppasalmi K. Long-term outcome after benzodiazepine withdrawal treatment in subjects with complicated dependence. Drug Alcohol Depend. 2003 Jun 5;70(3):309-14. doi: 10.1016/s0376-8716(03)00014-0.
Voshaar RC, Gorgels WJ, Mol AJ, van Balkom AJ, van de Lisdonk EH, Breteler MH, van den Hoogen HJ, Zitman FG. Tapering off long-term benzodiazepine use with or without group cognitive-behavioural therapy: three-condition, randomised controlled trial. Br J Psychiatry. 2003 Jun;182:498-504. doi: 10.1192/bjp.182.6.498.
Couvee JE, Timmermans MA, Zitman FG; Dutch Chronic Benzodiazepine Working Group. The long-term outcome of a benzodiazepine discontinuation programme in depressed outpatients. J Affect Disord. 2002 Jul;70(2):133-41. doi: 10.1016/s0165-0327(01)00330-5.
Mol AJ, Oude Voshaar RC, Gorgels WJ, Breteler MH, van Balkom AJ, van de Lisdonk EH, Kan CC, Mulder J, Zitman FG. The absence of benzodiazepine craving in a general practice benzodiazepine discontinuation trial. Addict Behav. 2006 Feb;31(2):211-22. doi: 10.1016/j.addbeh.2005.04.024. Epub 2005 Jun 13.
Morin CM, Bastien C, Guay B, Radouco-Thomas M, Leblanc J, Vallieres A. Randomized clinical trial of supervised tapering and cognitive behavior therapy to facilitate benzodiazepine discontinuation in older adults with chronic insomnia. Am J Psychiatry. 2004 Feb;161(2):332-42. doi: 10.1176/appi.ajp.161.2.332.
McGregor C, Machin A, White JM. In-patient benzodiazepine withdrawal: comparison of fixed and symptom-triggered taper methods. Drug Alcohol Rev. 2003 Jun;22(2):175-80. doi: 10.1080/09595230100100615.
Gorgels WJ, Oude Voshaar RC, Mol AJ, van de Lisdonk EH, van Balkom AJ, van den Hoogen HJ, Mulder J, Breteler MH, Zitman FG. Discontinuation of long-term benzodiazepine use by sending a letter to users in family practice: a prospective controlled intervention study. Drug Alcohol Depend. 2005 Apr 4;78(1):49-56. doi: 10.1016/j.drugalcdep.2004.09.001.
Oude Voshaar RC, Gorgels WJ, Mol AJ, Couvee JE, van Balkom AJ, Zitman FG. [Treatment methods for discontinuation of long-term benzodiazepine use]. Ned Tijdschr Geneeskd. 2001 Jul 14;145(28):1347-50. Dutch.
Cormack MA, Sweeney KG, Hughes-Jones H, Foot GA. Evaluation of an easy, cost-effective strategy for cutting benzodiazepine use in general practice. Br J Gen Pract. 1994 Jan;44(378):5-8.
van de Steeg-van Gompel CH, Wensing M, De Smet PA. Implementation of a discontinuation letter to reduce long-term benzodiazepine use--a cluster randomized trial. Drug Alcohol Depend. 2009 Jan 1;99(1-3):105-14. doi: 10.1016/j.drugalcdep.2008.07.009. Epub 2008 Sep 17.
Other Identifiers
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WOK/WINAp/CZ-01
Identifier Type: -
Identifier Source: org_study_id
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