Glycine Treatment of Prodromal Symptoms

NCT ID: NCT00268749

Last Updated: 2012-03-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2002-07-31

Study Completion Date

2004-11-30

Brief Summary

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This is an open label trial of the NMDA agonist glycine used alone for symptoms that appear to be prodromal for schizophrenia in adolescents and young adults.

Detailed Description

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Conditions

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Schizophrenia

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Group Type EXPERIMENTAL

glycine

Intervention Type DRUG

0.8 g/kg/day

Interventions

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glycine

0.8 g/kg/day

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* age 14-35
* meets SIPS criteria for psychosis prodrome

Exclusion Criteria

* current antipsychotic medication
* more than 4 weeks of antipsychotic medication lifetime
Minimum Eligible Age

14 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Stanley Medical Research Institute

OTHER

Sponsor Role collaborator

Yale University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Scott W Woods, MD

Role: PRINCIPAL_INVESTIGATOR

Yale University

References

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Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. doi: 10.1016/j.euroneuro.2012.09.008. Epub 2012 Oct 22.

Reference Type DERIVED
PMID: 23089076 (View on PubMed)

Other Identifiers

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02T-175

Identifier Type: -

Identifier Source: org_study_id

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