Survival Of Subjects With Chronic Obstructive Pulmonary Disease (COPD)

NCT ID: NCT00268216

Last Updated: 2017-01-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

6228 participants

Study Classification

INTERVENTIONAL

Study Start Date

2000-09-30

Study Completion Date

2005-11-30

Brief Summary

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The purpose of this study is to see if fluticasone 500mcg/salmeterol 50mcg can improve the survival of subjects with COPD and also assess the long term safety profile of this drug.

Detailed Description

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A multicenter, randomized, double-blind, parallel group, placebo controlled study to investigate the effects of salmeterol/fluticasone 50/500mcg bd, salmeterol 50mcg bd, and fluticasone 500mcg bd, all delivered via the DISKUS/ACCUHALER inhaler, on the survival of subjects with chronic obstructive pulmonary disease over 3 years of treatment.

Conditions

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Pulmonary Disease, Chronic Obstructive

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Interventions

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Salmeterol 50mcg/ Fluticasone Propionate 500mcg

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients with COPD and FEV1 \<60% of predicted normal and baseline (pre-bronchodilator) FEV1/FVC ratio \<70%.
* Current or ex-smokers with a smoking history of at least 10 pack-years.

Exclusion Criteria

* Diagnosis of other respiratory disorders (including asthma).
* Requirement for long term oxygen therapy.
Minimum Eligible Age

40 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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GlaxoSmithKline

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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GSK Clinical Trials

Role: STUDY_DIRECTOR

GlaxoSmithKline

Locations

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Birmingham, Alabama, United States

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Birmingham, Alabama, United States

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Birmingham, Alabama, United States

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Jasper, Alabama, United States

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Mobile, Alabama, United States

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Ozark, Alabama, United States

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Phoenix, Arizona, United States

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Phoenix, Arizona, United States

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Scottsdale, Arizona, United States

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Berkeley, California, United States

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Burbank, California, United States

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Encinitas, California, United States

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Fresno, California, United States

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Fullerton, California, United States

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Long Beach, California, United States

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Los Angeles, California, United States

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Los Angeles, California, United States

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Rancho Mirage, California, United States

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Riverside, California, United States

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San Diego, California, United States

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San Diego, California, United States

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San Diego, California, United States

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San Diego, California, United States

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San Diego, California, United States

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San Francisco, California, United States

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San Luis Obispo, California, United States

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Sepuldeva, California, United States

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Stockton, California, United States

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Sunnyvale, California, United States

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Sylmar, California, United States

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Vista, California, United States

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Walnut Creek, California, United States

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Arvada, Colorado, United States

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Denver, Colorado, United States

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Denver, Colorado, United States

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Fort Collins, Colorado, United States

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Longmont, Colorado, United States

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Loveland, Colorado, United States

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Pueblo, Colorado, United States

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Wheat Ridge, Colorado, United States

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Hartford, Connecticut, United States

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Stamford, Connecticut, United States

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Altamonte Springs, Florida, United States

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Atlantis, Florida, United States

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Bay Pines, Florida, United States

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Brandon, Florida, United States

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Clearwater, Florida, United States

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Fort Lauderdale, Florida, United States

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Jacksonville, Florida, United States

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Jacksonville, Florida, United States

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Largo, Florida, United States

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Longwood, Florida, United States

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Loxahatchee Groves, Florida, United States

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Miami, Florida, United States

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Pace, Florida, United States

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Palm Springs, Florida, United States

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Pensacola, Florida, United States

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Sarasota, Florida, United States

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Tamarac, Florida, United States

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Tampa, Florida, United States

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West Palm Beach, Florida, United States

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Zephyrhills, Florida, United States

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Atlanta, Georgia, United States

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Augusta, Georgia, United States

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Blue Ridge, Georgia, United States

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Decatur, Georgia, United States

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Marietta, Georgia, United States

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Rome, Georgia, United States

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Roswell, Georgia, United States

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Coeur d'Alene, Idaho, United States

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Champaign, Illinois, United States

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Chicago, Illinois, United States

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Chicago, Illinois, United States

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Hines, Illinois, United States

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North Chicago, Illinois, United States

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Peoria, Illinois, United States

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South Bend, Indiana, United States

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Dubuque, Iowa, United States

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Wichita, Kansas, United States

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Wichita, Kansas, United States

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Lexington, Kentucky, United States

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Louisville, Kentucky, United States

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Lafayette, Louisiana, United States

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Shreveport, Louisiana, United States

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Sunset, Louisiana, United States

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Auburn, Maine, United States

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Baltimore, Maryland, United States

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Boston, Massachusetts, United States

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Swansea, Massachusetts, United States

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Cadillac, Michigan, United States

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Livonia, Michigan, United States

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Saint Joseph, Michigan, United States

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Traverse City, Michigan, United States

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Edina, Minnesota, United States

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Minneapolis, Minnesota, United States

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Jackson, Mississippi, United States

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Chesterfield, Missouri, United States

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Jefferson City, Missouri, United States

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Kansas City, Missouri, United States

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Saint Charles, Missouri, United States

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St Louis, Missouri, United States

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St Louis, Missouri, United States

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Billings, Montana, United States

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Omaha, Nebraska, United States

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Omaha, Nebraska, United States

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Omaha, Nebraska, United States

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Omaha, Nebraska, United States

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Omaha, Nebraska, United States

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Las Vegas, Nevada, United States

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Gilford, New Hampshire, United States

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Lebanon, New Hampshire, United States

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East Orange, New Jersey, United States

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New Brunswick, New Jersey, United States

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Newark, New Jersey, United States

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Summit, New Jersey, United States

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Trenton, New Jersey, United States

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Albuquerque, New Mexico, United States

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Albany, New York, United States

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Albany, New York, United States

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Bronxville, New York, United States

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Brooklyn, New York, United States

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Buffalo, New York, United States

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Great Neck, New York, United States

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Mineola, New York, United States

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New York, New York, United States

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New York, New York, United States

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New York, New York, United States

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New York, New York, United States

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Chapel Hill, North Carolina, United States

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Charlotte, North Carolina, United States

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Elizabeth City, North Carolina, United States

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Greenville, North Carolina, United States

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High Point, North Carolina, United States

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Wilmington, North Carolina, United States

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Winston-Salem, North Carolina, United States

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Winston-Salem, North Carolina, United States

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Cincinnati, Ohio, United States

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Cincinnati, Ohio, United States

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Cleveland, Ohio, United States

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Franklin, Ohio, United States

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Toledo, Ohio, United States

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Toledo, Ohio, United States

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Oklahoma City, Oklahoma, United States

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Lake Oswego, Oregon, United States

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Medford, Oregon, United States

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Portland, Oregon, United States

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Portland, Oregon, United States

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Allentown, Pennsylvania, United States

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Downington, Pennsylvania, United States

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Doylestown, Pennsylvania, United States

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Erie, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Pittsburgh, Pennsylvania, United States

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Pittsburgh, Pennsylvania, United States

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Ridley Park, Pennsylvania, United States

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Cranston, Rhode Island, United States

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East Providence, Rhode Island, United States

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Charleston, South Carolina, United States

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Charleston, South Carolina, United States

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Greer, South Carolina, United States

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Simpsonville, South Carolina, United States

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Spartanburg, South Carolina, United States

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Bristol, Tennessee, United States

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Johnson City, Tennessee, United States

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Kingsport, Tennessee, United States

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Milan, Tennessee, United States

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Morristown, Tennessee, United States

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Corsicana, Texas, United States

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Houston, Texas, United States

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Houston, Texas, United States

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Houston, Texas, United States

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San Antonio, Texas, United States

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San Antonio, Texas, United States

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Salt Lake City, Utah, United States

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Chesapeake, Virginia, United States

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Fredericksburg, Virginia, United States

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Richmond, Virginia, United States

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Richmond, Virginia, United States

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Roanoke, Virginia, United States

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Virginia Beach, Virginia, United States

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Bellingham, Washington, United States

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Spokane, Washington, United States

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Spokane, Washington, United States

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Charleston, West Virginia, United States

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Huntington, West Virginia, United States

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La Crosse, Wisconsin, United States

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Madison, Wisconsin, United States

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Buenos Aires, Buenos Aires, Argentina

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La Plata, Buenos Aires, Argentina

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Vicente López, Buenos Aires, Argentina

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Bankstown, New South Wales, Australia

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Camperdown, New South Wales, Australia

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North Gosford, New South Wales, Australia

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Adelaide, South Australia, Australia

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Toorak Gardens, South Australia, Australia

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Frankston, Victoria, Australia

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Geelong, Victoria, Australia

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Heidelberg, Victoria, Australia

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Melbourne, Victoria, Australia

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Melbourne, Victoria, Australia

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Nedlands, Western Australia, Australia

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Vienna, , Austria

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Vienna, , Austria

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Vienna, , Austria

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Wels, , Austria

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Brussels, , Belgium

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Namur, , Belgium

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Orp-Jauche, , Belgium

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Ostend, , Belgium

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Veurne, , Belgium

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Rio de Janeiro, Rio de Janeiro, Brazil

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Rio de Janeiro, Rio de Janeiro, Brazil

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Rio de Janeiro, Rio de Janeiro, Brazil

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Porto Alegre, Rio Grande do Sul, Brazil

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Porto Alegre, Rio Grande do Sul, Brazil

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Santo André, São Paulo, Brazil

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São Paulo, São Paulo, Brazil

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Pleven, , Bulgaria

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Rousse, , Bulgaria

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Sofia, , Bulgaria

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Sofia, , Bulgaria

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Varna, , Bulgaria

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Calgary, Alberta, Canada

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Calgary, Alberta, Canada

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Edmonton, Alberta, Canada

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Maple Ridge, British Columbia, Canada

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Saint John, New Brunswick, Canada

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St. John's, Newfoundland and Labrador, Canada

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Mississauga, Ontario, Canada

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Mississauga, Ontario, Canada

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Scarborough Village, Ontario, Canada

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Thunder Bay, Ontario, Canada

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Toronto, Ontario, Canada

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Windsor, Ontario, Canada

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Montreal, Quebec, Canada

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Québec, Quebec, Canada

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Sainte-Foy, Quebec, Canada

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Sherbrooke, Quebec, Canada

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Sherbrooke, Quebec, Canada

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Temuco, Región de La Araucania, Chile

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Valparaíso, Región de Valparaíso, Chile

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Santiago, Región Metro de Santiago, Chile

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Guangzhou, Guangdong, China

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Nanjing, Jiangsu, China

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Shenyang, Liaoning, China

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Xi'an, Shaanxi, China

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Beijing, , China

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Beijing, , China

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Beijing, , China

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Beijing, , China

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Chongqing, , China

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Shanghai, , China

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Wangfujing, Beijing, , China

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Zagreb, , Croatia

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Hradec Králové, , Czechia

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Jaroměř, , Czechia

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Ostrava - Fifejdy, , Czechia

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Prague, , Czechia

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Prague, , Czechia

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Prague, , Czechia

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Tábor, , Czechia

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Aarhus C, , Denmark

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Hvidovre, , Denmark

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København NV, , Denmark

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Silkenborg, , Denmark

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Kohtal-Jdrve, , Estonia

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Tallinn, , Estonia

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Tartu, , Estonia

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Helsinki, , Finland

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Helsinki, , Finland

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Kinkomaa, , Finland

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Lappeenranta, , Finland

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Lohja, , Finland

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Mikkeli, , Finland

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Oulainen, , Finland

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Pori, , Finland

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Vantaa, , Finland

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Annonay, , France

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Avrillé, , France

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Béthune, , France

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Bois-Guillaume, , France

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Caen, , France

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Chamalières, , France

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Cholet, , France

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Corbeil Essonne, , France

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Férolles-Attilly, , France

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Grenoble, , France

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Lille, , France

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Lomme, , France

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Marseille, , France

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Maurepas, , France

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Meaux, , France

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Nantes, , France

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Nîmes, , France

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Nîmes, , France

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Paris, , France

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Saint-Quentin, , France

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Tarbes, , France

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Toulouse, , France

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Tours, , France

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Verdun, , France

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Schwetzingen, Baden-Wurttemberg, Germany

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Darmstadt, Hesse, Germany

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Kassel, Hesse, Germany

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Hanover, Lower Saxony, Germany

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Bielefeld, North Rhine-Westphalia, Germany

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Bad Segeberg, Schleswig-Holstein, Germany

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Berlin, State of Berlin, Germany

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Berlin, State of Berlin, Germany

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Berlin, State of Berlin, Germany

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Berlin, State of Berlin, Germany

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Athens, , Greece

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Chania, Crete, , Greece

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Heraklion, Crete, , Greece

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Heraklion, Crete, , Greece

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Kavala, , Greece

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Larissa, , Greece

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Maroussi, Athens, , Greece

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N. Efkarpia, Thessaloniki, , Greece

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Papagos/Athens, , Greece

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Pátrai, , Greece

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Thessaloniki, , Greece

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Thessaloniki, , Greece

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Aberdeen, , Hong Kong

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Kowloon, , Hong Kong

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Kwun Tong, , Hong Kong

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Lai Chi Kok, , Hong Kong

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Tai Po, , Hong Kong

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Budapest, , Hungary

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Cegléd, , Hungary

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Dunaújváros, , Hungary

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Szolnok, , Hungary

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Tatabánya, , Hungary

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Törökbálint, , Hungary

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Fossvogur. Reykjavic, , Iceland

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Reykjavik, , Iceland

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Ferrara, Emilia-Romagna, Italy

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Brescia, Lombardy, Italy

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Milan, Lombardy, Italy

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Sesto San Giovanni (MI), Lombardy, Italy

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Tradate (VA), Lombardy, Italy

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Pisa, Tuscany, Italy

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Bussolengo (VR), Veneto, Italy

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Riga, , Latvia

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Riga, , Latvia

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Kaunas, , Lithuania

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Kuala Lumpur, , Malaysia

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Kubang Kerian, , Malaysia

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Kuching, , Malaysia

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Tanjong Bungah, , Malaysia

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Guadalajara, Jalisco, Mexico

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Mexico City, , Mexico

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México, , Mexico

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Arnhem, , Netherlands

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Bilthoven, , Netherlands

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Breda, , Netherlands

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Dordrecht, , Netherlands

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Ede, , Netherlands

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Heerlen, , Netherlands

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Hengelo, , Netherlands

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Hoofddorp, , Netherlands

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Roosendaal, , Netherlands

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Terneuzen, , Netherlands

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Utrecht, , Netherlands

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Zwolle, , Netherlands

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Auckland, , New Zealand

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Auckland, , New Zealand

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Auckland, , New Zealand

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Hamilton, , New Zealand

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Tauranga, , New Zealand

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Wellington, , New Zealand

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Wellington South, , New Zealand

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Ålesund, , Norway

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Bardufoss, , Norway

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Bergen, , Norway

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Bodø, , Norway

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Harstad, , Norway

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Oslo, , Norway

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Oslo, , Norway

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Oslo, , Norway

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Oslo, , Norway

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Sandvika, , Norway

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Skien, , Norway

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Trondheim, , Norway

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Tønsberg, , Norway

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Volda, , Norway

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Lahore, , Pakistan

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Cebu City, , Philippines

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Manila, , Philippines

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Manila, , Philippines

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Quezon City, , Philippines

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Bialystok, , Poland

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Katowice, , Poland

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Warsaw, , Poland

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Wroclaw, , Poland

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Zabrze, , Poland

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Ponce, Puerto Rico, Puerto Rico

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Brasov, , Romania

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Bucharest, , Romania

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Bucharest, , Romania

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Iași, , Romania

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Moscow, , Russia

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Moscow, , Russia

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Moscow, , Russia

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Singapore, , Singapore

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Singapore, , Singapore

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Singapore, , Singapore

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Singapore, , Singapore

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Banská Bystrica, , Slovakia

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Kráľovský Chlmec, , Slovakia

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Nové Zámky, , Slovakia

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Partizánske, , Slovakia

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Durban, KwaZulu-Natal, South Africa

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Cape Town, , South Africa

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Cape Town, , South Africa

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Mowbray, , South Africa

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Pretoria, , South Africa

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Pretoria, , South Africa

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A Coruña, , Spain

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Alicante, , Spain

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Barakaldo (Vizcaya), , Spain

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Barcelona, , Spain

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Cadiz, , Spain

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Cartagena, , Spain

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Elda, , Spain

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Guadalajara, , Spain

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Madrid, , Spain

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Madrid, , Spain

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Orihuela/Alicante, , Spain

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Santiago de Compostela, , Spain

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Valencia, , Spain

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Vigo/Pontevedra, , Spain

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Vizcaya, , Spain

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Boden, , Sweden

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Eksjö, , Sweden

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Gothenburg, , Sweden

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Helsingborg, , Sweden

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Helsingborg, , Sweden

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Lidköping, , Sweden

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Trollhättan, , Sweden

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Kaohsiung City, , Taiwan

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Taichung, , Taiwan

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Tainan City, , Taiwan

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Taipei, , Taiwan

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Tau-Yuan County, , Taiwan

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Bangkok, , Thailand

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Chiang Mai, , Thailand

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Kiev, , Ukraine

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Exeter, Devon, United Kingdom

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Bristol, Gloucestershire, United Kingdom

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Liverpool, Lancashire, United Kingdom

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Manchester, Lancashire, United Kingdom

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Newcastle upon Tyne, Northumberland, United Kingdom

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Headington, Oxfordshire, United Kingdom

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London, , United Kingdom

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, ,

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Countries

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United States Argentina Australia Austria Belgium Brazil Bulgaria Canada Chile China Croatia Czechia Denmark Estonia Finland France Germany Greece Hong Kong Hungary Iceland Italy Latvia Lithuania Malaysia Mexico Netherlands New Zealand Norway Pakistan Philippines Poland Puerto Rico Romania Russia Singapore Slovakia South Africa Spain Sweden Taiwan Thailand Ukraine United Kingdom

References

Explore related publications, articles, or registry entries linked to this study.

Briggs AH, Glick HA, Lozano-Ortega G, Spencer M, Calverley PM, Jones PW, Vestbo J; TOwards a Revolution in COPD Health (TORCH) investigators. Is treatment with ICS and LABA cost-effective for COPD? Multinational economic analysis of the TORCH study. Eur Respir J. 2010 Mar;35(3):532-9. doi: 10.1183/09031936.00153108. Epub 2009 Aug 28.

Reference Type BACKGROUND
PMID: 19717476 (View on PubMed)

Calverley PM, Anderson JA, Celli B, Ferguson GT, Jenkins C, Jones PW, Yates JC, Vestbo J; TORCH investigators. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N Engl J Med. 2007 Feb 22;356(8):775-89. doi: 10.1056/NEJMoa063070.

Reference Type BACKGROUND
PMID: 17314337 (View on PubMed)

Celli BR, Thomas NE, Anderson JA, Ferguson GT, Jenkins CR, Jones PW, Vestbo J, Knobil K, Yates JC, Calverley PM. Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study. Am J Respir Crit Care Med. 2008 Aug 15;178(4):332-8. doi: 10.1164/rccm.200712-1869OC. Epub 2008 May 29.

Reference Type BACKGROUND
PMID: 18511702 (View on PubMed)

Jenkins CR, Jones PW, Calverley PM, Celli B, Anderson JA, Ferguson GT, Yates JC, Willits LR, Vestbo J. Efficacy of salmeterol/fluticasone propionate by GOLD stage of chronic obstructive pulmonary disease: analysis from the randomised, placebo-controlled TORCH study. Respir Res. 2009 Jun 30;10(1):59. doi: 10.1186/1465-9921-10-59.

Reference Type BACKGROUND
PMID: 19566934 (View on PubMed)

Crim C, Calverley PM, Anderson JA, Celli B, Ferguson GT, Jenkins C, Jones PW, Willits LR, Yates JC, Vestbo J. Pneumonia risk in COPD patients receiving inhaled corticosteroids alone or in combination: TORCH study results. Eur Respir J. 2009 Sep;34(3):641-7. doi: 10.1183/09031936.00193908. Epub 2009 May 14.

Reference Type BACKGROUND
PMID: 19443528 (View on PubMed)

Ernst P, Suissa S. Pneumonia in elderly patients with chronic obstructive pulmonary disease. Curr Infect Dis Rep. 2008 May;10(3):223-8. doi: 10.1007/s11908-008-0037-4.

Reference Type BACKGROUND
PMID: 18510885 (View on PubMed)

Ferguson GT, Calverley PMA, Anderson JA, Jenkins CR, Jones PW, Willits LR, Yates JC, Vestbo J, Celli B. Prevalence and progression of osteoporosis in patients with COPD: results from the TOwards a Revolution in COPD Health study. Chest. 2009 Dec;136(6):1456-1465. doi: 10.1378/chest.08-3016. Epub 2009 Jul 6.

Reference Type BACKGROUND
PMID: 19581353 (View on PubMed)

Hanania NA. The impact of inhaled corticosteroid and long-acting beta-agonist combination therapy on outcomes in COPD. Pulm Pharmacol Ther. 2008;21(3):540-50. doi: 10.1016/j.pupt.2007.12.004. Epub 2008 Jan 6.

Reference Type BACKGROUND
PMID: 18280761 (View on PubMed)

Houghton CM, Lawson N, Borrill ZL, Wixon CL, Yoxall S, Langley SJ, Woodcock A, Singh D. Comparison of the effects of salmeterol/fluticasone propionate with fluticasone propionate on airway physiology in adults with mild persistent asthma. Respir Res. 2007 Jul 14;8(1):52. doi: 10.1186/1465-9921-8-52.

Reference Type BACKGROUND
PMID: 17629923 (View on PubMed)

Johnson M, Agusti AG, Barnes NC. Reflections on TORCH: potential mechanisms for the survival benefit of salmeterol/fluticasone propionate in COPD patients. COPD. 2008 Dec;5(6):369-75. doi: 10.1080/15412550802522924.

Reference Type BACKGROUND
PMID: 19353351 (View on PubMed)

Keene ON, Vestbo J, Anderson JA, Calverley PM, Celli B, Ferguson GT, Jenkins C, Jones PW. Methods for therapeutic trials in COPD: lessons from the TORCH trial. Eur Respir J. 2009 Nov;34(5):1018-23. doi: 10.1183/09031936.00122608.

Reference Type BACKGROUND
PMID: 19880616 (View on PubMed)

Drummond MB, Wise RA, John M, Zvarich MT, McGarvey LP. Accuracy of death certificates in COPD: analysis from the TORCH trial. COPD. 2010 Jun;7(3):179-85. doi: 10.3109/15412555.2010.481695.

Reference Type BACKGROUND
PMID: 20486816 (View on PubMed)

Marchand E. Effect of pharmacotherapy on rate of decline of FEV(1) in the TORCH study. Am J Respir Crit Care Med. 2009 Mar 1;179(5):426; author reply 426-7. doi: 10.1164/ajrccm.179.5.426. No abstract available.

Reference Type BACKGROUND
PMID: 19234322 (View on PubMed)

McGarvey LP, John M, Anderson JA, Zvarich M, Wise RA; TORCH Clinical Endpoint Committee. Ascertainment of cause-specific mortality in COPD: operations of the TORCH Clinical Endpoint Committee. Thorax. 2007 May;62(5):411-5. doi: 10.1136/thx.2006.072348. Epub 2007 Feb 20.

Reference Type BACKGROUND
PMID: 17311843 (View on PubMed)

Middleton PG. Management of patients with COPD: a comparison of the INSPIRE and TORCH studies. Am J Respir Crit Care Med. 2008 Jul 1;178(1):106; author reply 106-7. doi: 10.1164/ajrccm.178.1.106. No abstract available.

Reference Type BACKGROUND
PMID: 18565964 (View on PubMed)

Miravitlles M, Anzueto A. Insights into interventions in managing COPD patients: lessons from the TORCH and UPLIFT studies. Int J Chron Obstruct Pulmon Dis. 2009;4:185-201. Epub 2009 May 7.

Reference Type BACKGROUND
PMID: 19516917 (View on PubMed)

Niewoehner DE. TORCH and UPLIFT: what has been learned from the COPD "mega-trials"? COPD. 2009 Feb;6(1):1-3. doi: 10.1080/15412550902723984.

Reference Type BACKGROUND
PMID: 19229702 (View on PubMed)

Calverley PM, Anderson JA, Celli B, Ferguson GT, Jenkins C, Jones PW, Crim C, Willits LR, Yates JC, Vestbo J; TORCH Investigators. Cardiovascular events in patients with COPD: TORCH study results. Thorax. 2010 Aug;65(8):719-25. doi: 10.1136/thx.2010.136077.

Reference Type BACKGROUND
PMID: 20685748 (View on PubMed)

Salmeterol plus fluticasone fails to reduce mortality in patients with COPD. Formulary 2007;42:245-6.

Reference Type BACKGROUND

Stockley RA. Progression of chronic obstructive pulmonary disease: impact of inflammation, comorbidities and therapeutic intervention. Curr Med Res Opin. 2009 May;25(5):1235-45. doi: 10.1185/03007990902868971.

Reference Type BACKGROUND
PMID: 19335322 (View on PubMed)

Suissa S, Ernst P, Vandemheen KL, Aaron SD. Methodological issues in therapeutic trials of COPD. Eur Respir J. 2008 May;31(5):927-33. doi: 10.1183/09031936.00098307. Epub 2008 Jan 23.

Reference Type BACKGROUND
PMID: 18216056 (View on PubMed)

Vestbo J; TORCH Study Group. The TORCH (towards a revolution in COPD health) survival study protocol. Eur Respir J. 2004 Aug;24(2):206-10. doi: 10.1183/09031936.04.00120603.

Reference Type BACKGROUND
PMID: 15332386 (View on PubMed)

Vestbo J, Anderson JA, Calverley PM, Celli B, Ferguson GT, Jenkins C, Knobil K, Willits LR, Yates JC, Jones PW. Adherence to inhaled therapy, mortality and hospital admission in COPD. Thorax. 2009 Nov;64(11):939-43. doi: 10.1136/thx.2009.113662. Epub 2009 Aug 23.

Reference Type BACKGROUND
PMID: 19703830 (View on PubMed)

Paly VF, Naya I, Gunsoy NB, Driessen MT, Risebrough N, Briggs A, Ismaila AS. Long-term cost and utility consequences of short-term clinically important deterioration in patients with chronic obstructive pulmonary disease: results from the TORCH study. Int J Chron Obstruct Pulmon Dis. 2019 May 3;14:939-951. doi: 10.2147/COPD.S188898. eCollection 2019.

Reference Type DERIVED
PMID: 31190781 (View on PubMed)

Naya IP, Tombs L, Muellerova H, Compton C, Jones PW. Long-term outcomes following first short-term clinically important deterioration in COPD. Respir Res. 2018 Nov 20;19(1):222. doi: 10.1186/s12931-018-0928-3.

Reference Type DERIVED
PMID: 30453972 (View on PubMed)

Jenkins CR, Celli B, Anderson JA, Ferguson GT, Jones PW, Vestbo J, Yates JC, Calverley PM. Seasonality and determinants of moderate and severe COPD exacerbations in the TORCH study. Eur Respir J. 2012 Jan;39(1):38-45. doi: 10.1183/09031936.00194610. Epub 2011 Jul 7.

Reference Type DERIVED
PMID: 21737561 (View on PubMed)

Jones PW, Anderson JA, Calverley PM, Celli BR, Ferguson GT, Jenkins C, Yates JC, Vestbo J, Spencer MD; TORCH investigators. Health status in the TORCH study of COPD: treatment efficacy and other determinants of change. Respir Res. 2011 May 31;12(1):71. doi: 10.1186/1465-9921-12-71.

Reference Type DERIVED
PMID: 21627828 (View on PubMed)

Celli B, Vestbo J, Jenkins CR, Jones PW, Ferguson GT, Calverley PM, Yates JC, Anderson JA, Willits LR, Wise RA; Investigators of the TORCH Study. Sex differences in mortality and clinical expressions of patients with chronic obstructive pulmonary disease. The TORCH experience. Am J Respir Crit Care Med. 2011 Feb 1;183(3):317-22. doi: 10.1164/rccm.201004-0665OC. Epub 2010 Sep 2.

Reference Type DERIVED
PMID: 20813884 (View on PubMed)

Study Documents

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Document Type: Annotated Case Report Form

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Document Type: Informed Consent Form

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Document Type: Clinical Study Report

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Document Type: Dataset Specification

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Document Type: Study Protocol

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Document Type: Individual Participant Data Set

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Document Type: Statistical Analysis Plan

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Related Links

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Other Identifiers

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SCO30003

Identifier Type: -

Identifier Source: org_study_id

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