Study of RSD1235-SR for the Prevention of Atrial Fibrillation/Atrial Flutter Recurrence

NCT ID: NCT00267930

Last Updated: 2008-12-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

221 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-12-31

Study Completion Date

2006-08-31

Brief Summary

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This study is designed to evaluate the safety, tolerability and preliminary efficacy of vernakalant (oral) in subjects with sustained atrial fibrillation of greater than 72 hours and less than 6 months duration

Detailed Description

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Conditions

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Atrial Fibrillation

Keywords

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AFib AF

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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1

Tier 1: 1 placebo capsule b.i.d Tier 2: 2 placebo capsules b.i.d

Group Type PLACEBO_COMPARATOR

Placebo comparator

Intervention Type DRUG

2

Tier 1: Vernakalant (oral) 1 x 300 mg capsule b.i.d

Group Type EXPERIMENTAL

Vernakalant (oral)

Intervention Type DRUG

3

Tier 2: Vernakalant (oral) 2 x 300 mg (600 mg) b.i.d

Group Type EXPERIMENTAL

Vernakalant (oral)

Intervention Type DRUG

Interventions

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Vernakalant (oral)

Intervention Type DRUG

Placebo comparator

Intervention Type DRUG

Other Intervention Names

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RSD1235-SR

Eligibility Criteria

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Inclusion Criteria

* Subjects must have sustained, symptomatic atrial fibrillation for greater than 72 hours and less than 6 months duration
* Subjects must have adequate anticoagulant therapy

Exclusion Criteria

* Subjects may not have Class III or Class IV congestive heart failure
* Subjects may not have uncorrected electrolyte imbalance
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Advanz Pharma

INDUSTRY

Sponsor Role lead

Responsible Party

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Cardiome Pharma Corp.

Principal Investigators

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Greg Beatch, PhD

Role: STUDY_DIRECTOR

Advanz Pharma

Locations

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The Heart Center, P.C.

Huntsville, Alabama, United States

Site Status

Cardiovascular Consultants Medical Group, Inc.

Walnut Creek, California, United States

Site Status

Penn State Heart & Vascular Institute

Hershey, Pennsylvania, United States

Site Status

Marshfield Clinic

Marshfield, Wisconsin, United States

Site Status

Foothills Hospital

Calgary, Alberta, Canada

Site Status

Centre Hospitalier de l'Université de Montréal (CHUM) Hôtel Dieu

Montreal, Quebec, Canada

Site Status

Aalborg Sygehus Syd

Aalborg, , Denmark

Site Status

Aarhus Sygehus Kardiologisk Afd. A

Aarhus, , Denmark

Site Status

Bispebjerg Hospital

Copenhagen, , Denmark

Site Status

Kardiologisk/endokrinologisk afd. E Frederiksberg Hospital

Frederiksberg, , Denmark

Site Status

KAS Gentofte Kardiologisk Afdeling

Hellerup, , Denmark

Site Status

KAS Herlev

Herlev, , Denmark

Site Status

Sygehus Vendsyssel Hjorring

Hjørring, , Denmark

Site Status

Medicinsk Afdeling Kolding Sygehus

Kolding, , Denmark

Site Status

Roskilde Amts Sygehus Koge

Køge, , Denmark

Site Status

Reinier de Graaf Gasthuis

Delft, , Netherlands

Site Status

Catharina Ziekenhuis

Eindhoven, , Netherlands

Site Status

Medisch Spectrum Twente

Enschede, , Netherlands

Site Status

University Medical Center Groningen (UMCG)

Groningen, , Netherlands

Site Status

Trial sectie Cardiologie

Heerlen, , Netherlands

Site Status

Academisch Ziekenhuis Maastricht

Maastricht, , Netherlands

Site Status

Stichting Sint Antonius Ziekenhuis

Nieuwegein, , Netherlands

Site Status

Countries

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United States Canada Denmark Netherlands

Related Links

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Other Identifiers

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1235-SR-1005

Identifier Type: -

Identifier Source: org_study_id