Comprehensive Rimonabant Evaluation Study of Cardiovascular ENDpoints and Outcomes

NCT ID: NCT00263042

Last Updated: 2016-05-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

18695 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-12-31

Study Completion Date

2009-04-30

Brief Summary

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The primary objective is to show whether rimonabant reduces the risk of a heart attack (MI), stroke, or death from an MI or stroke in patients with abdominal obesity with other cardiovascular (CV) risk factors.

The secondary objective is to show whether rimonabant reduces the risk of MI, stroke, CV death, or CV hospitalization in these patients.

Detailed Description

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The estimated study duration per patient is 36 to 53 months. All patients will be followed from randomization until a common study end date, which will occur when the last patient has been followed for 33 months.

Conditions

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Cardiovascular Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Rimonabant

Rimonabant 20 mg once daily

Group Type EXPERIMENTAL

Rimonabant

Intervention Type DRUG

Tablet, oral administration

Placebo

Placebo (for Rimonabant) once daily.

Group Type PLACEBO_COMPARATOR

Placebo (for Rimonabant)

Intervention Type DRUG

Tablet, oral administration

Interventions

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Rimonabant

Tablet, oral administration

Intervention Type DRUG

Placebo (for Rimonabant)

Tablet, oral administration

Intervention Type DRUG

Other Intervention Names

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SR141716 Acomplia

Eligibility Criteria

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Inclusion Criteria

Waist circumference \>102 cm (40 inches) males, \>88 cm (35 inches) females, with one coronary heart disease (CHD) equivalent or two major risk factors for cardiovascular disease.

* CHD equivalents:

* Recent (within 3 years)documented heart attack
* Documented symptomatic coronary artery disease
* Recent (within 3 years) ischemic cerebrovascular episode (stroke or TIA)
* Documented symptomatic peripheral arterial disease
* Major risk factors:

* Documented type 2 diabetes mellitus
* Metabolic syndrome (NCEP criteria)
* Asymptomatic cerebrovascular, renal, or peripheral arterial disease, or past abdominal aortic aneurysm repair
* Elevated high-sensitivity C-reactive protein
* Age \> or = 65 years for males, age \> or = 70 years for females

Exclusion Criteria

* Obesity of known endocrine origin
* Pregnant or breastfeeding women
* Very low calorie diet or weight loss surgery within past 6 months
* Presence of any severe medical or psychological condition that, in the opinion of the investigator, would compromise the patient's safe participation, including uncontrolled serious psychiatric illness
* Likely cardiovascular intervention within next 1 month
* Allergy to rimonabant or excipients, or prior participation in a rimonabant trial
* Receipt of investigational product within past 30 days
Minimum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sanofi

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Eric Topol, MD

Role: STUDY_CHAIR

Scripps Clinic

Deepak L. Bhatt, MD

Role: PRINCIPAL_INVESTIGATOR

The Cleveland Clinic

Locations

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Sanofi-Aventis Administrative Office

Bridgewater, New Jersey, United States

Site Status

Sanofi-Aventis Administrative Office

Buenos Aires, , Argentina

Site Status

sanofi-aventis Australia & New Zealand administrative office

Macquarie Park, New South Wales, Australia

Site Status

Sanofi-Aventis Administrative Office

Vienna, , Austria

Site Status

Sanofi-Aventis Administrative Office

Diegem, , Belgium

Site Status

Sanofi-Aventis Administrative Office

São Paulo, , Brazil

Site Status

Sanofi-Aventis Administrative Office

Laval, Quebec, Canada

Site Status

Sanofi-Aventis Administrative Office

Santiago, , Chile

Site Status

Sanofi-Aventis Administrative Office

Shangaï, , China

Site Status

Sanofi-Aventis Administrative Office

Bogotá, , Colombia

Site Status

Sanofi-Aventis Administrative Office

Prague, , Czechia

Site Status

Sanofi-Aventis Administrative Office

Hørsholm, , Denmark

Site Status

Sanofi-Aventis Administrative Office

Helsinki, , Finland

Site Status

Sanofi-Aventis Administrative Office

Paris, , France

Site Status

Sanofi-Aventis Administrative Office

Berlin, , Germany

Site Status

Sanofi-Aventis Administrative Office

Athens, , Greece

Site Status

Sanofi-Aventis Administrative Office

Hong Kong, , Hong Kong

Site Status

Sanofi-Aventis Administrative Office

Budapest, , Hungary

Site Status

Sanofi-Aventis Administrative Office

Mumbai, , India

Site Status

Sanofi-Aventis Administrative Office

Dublin, , Ireland

Site Status

Sanofi-Aventis Administrative Office

Netanya, , Israel

Site Status

Sanofi-Aventis Administrative Office

Milan, , Italy

Site Status

Sanofi-Aventis Administrative Office

Kuala Lumpur, , Malaysia

Site Status

Sanofi-Aventis Administrative Office

México, , Mexico

Site Status

Sanofi-Aventis Administrative Office

Gouda, , Netherlands

Site Status

Sanofi-Aventis Administrative Office

Lysaker, , Norway

Site Status

Sanofi-Aventis Administrative Office

Lima, , Peru

Site Status

Sanofi-Aventis Administrative Office

Makati City, , Philippines

Site Status

Sanofi-Aventis Administrative Office

Warsaw, , Poland

Site Status

Sanofi-Aventis Administrative Office

Porto Salvo, , Portugal

Site Status

Sanofi-Aventis Administrative Office

Bucharest, , Romania

Site Status

Sanofi-Aventis Administrative Office

Moscow, , Russia

Site Status

Sanofi-Aventis Administrative Office

Singapore, , Singapore

Site Status

Sanofi-Aventis Administrative Office

Midrand, , South Africa

Site Status

Sanofi-Aventis Administrative Office

Seoul, , South Korea

Site Status

Sanofi-Aventis Administrative Office

Madrid, , Spain

Site Status

Sanofi-Aventis Administrative Office

Bromma, , Sweden

Site Status

Sanofi-Aventis Administrative Office

Geneva, , Switzerland

Site Status

Sanofi-Aventis Administrative Office

Taipei, , Taiwan

Site Status

Sanofi-Aventis Administrative Office

Bangkok, , Thailand

Site Status

Sanofi-Aventis Administrative Office

Mégrine, , Tunisia

Site Status

Sanofi-Aventis Administrative Office

Istanbul, , Turkey (Türkiye)

Site Status

Sanofi-Aventis Administrative Office

Guildford, , United Kingdom

Site Status

Countries

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United States Argentina Australia Austria Belgium Brazil Canada Chile China Colombia Czechia Denmark Finland France Germany Greece Hong Kong Hungary India Ireland Israel Italy Malaysia Mexico Netherlands Norway Peru Philippines Poland Portugal Romania Russia Singapore South Africa South Korea Spain Sweden Switzerland Taiwan Thailand Tunisia Turkey (Türkiye) United Kingdom

References

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Topol EJ, Bousser MG, Fox KA, Creager MA, Despres JP, Easton JD, Hamm CW, Montalescot G, Steg PG, Pearson TA, Cohen E, Gaudin C, Job B, Murphy JH, Bhatt DL; CRESCENDO Investigators. Rimonabant for prevention of cardiovascular events (CRESCENDO): a randomised, multicentre, placebo-controlled trial. Lancet. 2010 Aug 14;376(9740):517-23. doi: 10.1016/S0140-6736(10)60935-X.

Reference Type RESULT
PMID: 20709233 (View on PubMed)

Bhatia G, Bansal V, Harismendy O, Schork NJ, Topol EJ, Frazer K, Bafna V. A covering method for detecting genetic associations between rare variants and common phenotypes. PLoS Comput Biol. 2010 Oct 14;6(10):e1000954. doi: 10.1371/journal.pcbi.1000954.

Reference Type DERIVED
PMID: 20976246 (View on PubMed)

Other Identifiers

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2005-002942-20

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

EFC5826

Identifier Type: -

Identifier Source: org_study_id

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