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Study of the Effects of Chemotherapy on Memory and Other Mental Functions in Women With Breast Cancer

NCT ID: NCT00260975

Last Updated: 2017-09-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

112 participants

Study Classification

OBSERVATIONAL

Study Start Date

2001-06-30

Study Completion Date

2008-02-29

Brief Summary

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Many breast cancer patients treated with chemotherapy complain of problems with concentration and memory. This has been referred to as chemo fog. The current study is investigating this phenomenon by measuring mental function of breast cancer patients prior to and after exposure to chemotherapy, and by comparing mental function in those patients who receive chemotherapy and those who do not.

Detailed Description

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Many breast cancer patients treated with chemotherapy complain of problems with concentration and memory. This has been referred to as chemo fog. The current study will investigate this phenomenon by measuring neuropsychological functioning in early stage breast cancer patients prior to and after exposure to chemotherapy, and by comparing change in cognitive function in patients who receive chemotherapy to similar breast cancer patients receiving hormonal therapy only.

Conditions

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Breast Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Chemotherapy patients

Breast cancer patients treated with adjuvant chemotherapy of various types.

No interventions assigned to this group

Hormonal patients

Breast cancer patients treated with adjuvant hormonal therapy but not chemotherapy.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* stage I or II breast cancer; woman; 50-65 years old; post-menopausal

Exclusion Criteria

* history of previous cancer or chemotherapy; significant neurological or psychiatric history
Minimum Eligible Age

50 Years

Maximum Eligible Age

65 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Canadian Breast Cancer Foundation

OTHER

Sponsor Role collaborator

Ottawa Hospital Research Institute

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Barbara Collins

Role: PRINCIPAL_INVESTIGATOR

OHRI

References

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Stewart A, Collins B, Mackenzie J, Tomiak E, Verma S, Bielajew C. The cognitive effects of adjuvant chemotherapy in early stage breast cancer: a prospective study. Psychooncology. 2008 Feb;17(2):122-30. doi: 10.1002/pon.1210.

Reference Type RESULT
PMID: 17518411 (View on PubMed)

Collins B, Mackenzie J, Stewart A, Bielajew C, Verma S. Cognitive effects of chemotherapy in post-menopausal breast cancer patients 1 year after treatment. Psychooncology. 2009 Feb;18(2):134-43. doi: 10.1002/pon.1379.

Reference Type RESULT
PMID: 18551510 (View on PubMed)

Collins B, Mackenzie J, Stewart A, Bielajew C, Verma S. Cognitive effects of hormonal therapy in early stage breast cancer patients: a prospective study. Psychooncology. 2009 Aug;18(8):811-21. doi: 10.1002/pon.1453.

Reference Type RESULT
PMID: 19085975 (View on PubMed)

Other Identifiers

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1999232-01H

Identifier Type: -

Identifier Source: org_study_id