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Effects of Gynecological Age on LH Sensitivity to Energy Availability

NCT ID: NCT00260286

Last Updated: 2005-12-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

18 participants

Study Classification

INTERVENTIONAL

Study Start Date

2001-08-31

Study Completion Date

2004-05-31

Brief Summary

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The purpose of this experiment is to investigate whether the dependence of luteinizing hormone pulsatility on energy availability declines during adolescence.

Detailed Description

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The incidence of menstrual disorders declines during adolescence. This has long been attributed to the gradual "maturation" of the hypothalamic-pituitary-ovarian axis, but the mechanism of this "maturation" is not known. Ovarian function critically depends on the pulsatile secretion of gonadotropin-releasing hormone (GnRH) by the hypothalamus and on the consequent and more readily assessed pulsatility of luteinizing hormone (LH) secretion by the pituitary. LH pulsatility has been shown to depend on energy availability, operationally defined as dietary energy intake minus exercise energy expenditure. The effects of energy availability on LH pulsatility are thought to be mediated by certain metabolic substrates and hormones.

Comparison: By manipulating diet and exercise regimens, contrasting energy availability treatments of 10 and 45 kilocalories per kilogram of fat-free mass per day are being administered to adolescents with 5-8 years of gynecological age and to adults with 14-18 years of gynecological age for five days in the early follicular phase of separate menstrual cycles. Effects of low energy availability on LH pulsatility and on selected metabolic substrates and hormones are being measured.

Conditions

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Anovulation Amenorrhea Infertility Starvation

Keywords

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LH pulsatility energy availability exercise diet gynecological age

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Interventions

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Energy availability

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* 5-8 or 14-18 years of gynecological age
* menstrual cycles of 26 to 32 days for the previous 3 months
* luteal phase length \>11 days
* 18-32% body fat

Exclusion Criteria

* smoking
* oral contraceptives
* hematocrit \<35%
* diet with \<35 or \>55 kcal/kgFFM/day of energy
* habitually performing more than 60 minutes/week of aerobic exercise
* histories or evidence of heart, liver, or kidney disease, diabetes, menstrual or thyroid disorders, pregnancy, lactation, and congenital or acquired orthopedic abnormalities
Minimum Eligible Age

18 Years

Maximum Eligible Age

34 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Ohio State University

OTHER

Sponsor Role collaborator

Ohio University

OTHER

Sponsor Role lead

Principal Investigators

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Anne B Loucks, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Ohio University

Locations

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Ohio University

Athens, Ohio, United States

Site Status

Countries

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United States

References

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Loucks AB, Verdun M, Heath EM. Low energy availability, not stress of exercise, alters LH pulsatility in exercising women. J Appl Physiol (1985). 1998 Jan;84(1):37-46. doi: 10.1152/jappl.1998.84.1.37.

Reference Type BACKGROUND
PMID: 9451615 (View on PubMed)

Loucks AB, Heath EM. Induction of low-T3 syndrome in exercising women occurs at a threshold of energy availability. Am J Physiol. 1994 Mar;266(3 Pt 2):R817-23. doi: 10.1152/ajpregu.1994.266.3.R817.

Reference Type BACKGROUND
PMID: 8160876 (View on PubMed)

Hilton LK, Loucks AB. Low energy availability, not exercise stress, suppresses the diurnal rhythm of leptin in healthy young women. Am J Physiol Endocrinol Metab. 2000 Jan;278(1):E43-9. doi: 10.1152/ajpendo.2000.278.1.E43.

Reference Type BACKGROUND
PMID: 10644535 (View on PubMed)

Loucks AB, Callister R. Induction and prevention of low-T3 syndrome in exercising women. Am J Physiol. 1993 May;264(5 Pt 2):R924-30. doi: 10.1152/ajpregu.1993.264.5.R924.

Reference Type BACKGROUND
PMID: 8498602 (View on PubMed)

Loucks AB, Heath EM. Dietary restriction reduces luteinizing hormone (LH) pulse frequency during waking hours and increases LH pulse amplitude during sleep in young menstruating women. J Clin Endocrinol Metab. 1994 Apr;78(4):910-5. doi: 10.1210/jcem.78.4.8157720.

Reference Type BACKGROUND
PMID: 8157720 (View on PubMed)

Loucks AB, Verdun M. Slow restoration of LH pulsatility by refeeding in energetically disrupted women. Am J Physiol. 1998 Oct;275(4):R1218-26. doi: 10.1152/ajpregu.1998.275.4.R1218.

Reference Type BACKGROUND
PMID: 9756553 (View on PubMed)

Loucks AB, Thuma JR. Luteinizing hormone pulsatility is disrupted at a threshold of energy availability in regularly menstruating women. J Clin Endocrinol Metab. 2003 Jan;88(1):297-311. doi: 10.1210/jc.2002-020369.

Reference Type BACKGROUND
PMID: 12519869 (View on PubMed)

Ihle R, Loucks AB. Dose-response relationships between energy availability and bone turnover in young exercising women. J Bone Miner Res. 2004 Aug;19(8):1231-40. doi: 10.1359/JBMR.040410. Epub 2004 Apr 19.

Reference Type BACKGROUND
PMID: 15231009 (View on PubMed)

Other Identifiers

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DAMD_17-95-1-5053,

Identifier Type: -

Identifier Source: secondary_id

M01RR000034

Identifier Type: NIH

Identifier Source: secondary_id

View Link

Excalibur X

Identifier Type: -

Identifier Source: org_study_id