Effect of Atomoxetine on ADHD-Related Insomnia in Children and Adolescents

NCT ID: NCT00252278

Last Updated: 2006-07-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE4

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-11-30

Brief Summary

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Children and adolescents with Attention-Deficit/Hyperactivity Disorder (ADHD) very commonly experience difficulty in initiating and maintaining sleep. Studies have shown that daytime sleepiness resulting from insufficient sleep can affect attention and learning. Therefore, treating insomnia in children with ADHD may not only improve sleep, but it could potentially improve ADHD symptoms as well.

The main purpose of this study is to examine the effects of atomoxetine on ADHD-related insomnia. Atomoxetine (Strattera®) is a non-stimulant drug used to treat ADHD symptoms in both children and adults, and there is evidence that it may also have a positive effect on sleep in children with ADHD. During the study, participants will receive either atomoxetine or placebo for a period of four weeks. We expect that the effects of atomoxetine on sleep will differ from those of placebo, with atomoxetine having a greater effect on improving sleep difficulties.

Detailed Description

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Conditions

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Attention-Deficit/Hyperactivity Disorder (ADHD) Insomnia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Interventions

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atomoxetine

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Boy or girl aged 6-17 years, inclusive, and English-speaking
* Meet the DSM-IV criteria for Attention-Deficit/Hyperactivity Disorder
* Have sleep initiation defined by:

1. difficulty initiating or maintaining sleep that is viewed as a problem by the child or caregiver
2. sleep onset delay that is not exclusively related to direct or rebound effects of psychostimulant treatment
* Have a parent or legal guardian willing to participate in the study

Exclusion Criteria

* Have any other primary sleep disorder(s) (e.g. obstructive sleep apnea or periodic limb movement disorder)
* Have a history of significant chronic medical (e.g. diabetes, severe asthma) or psychiatric (e.g. depression) illness
* Have a history of chronic use of sedating (e.g. antihistamines) or alertness enhancing (e.g. caffeine) medications
* Have a history of failure to respond to an adequate (defined as appropriate dose and adequate duration of therapy) previous trial with atomoxetine
Minimum Eligible Age

6 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Eli Lilly and Company

INDUSTRY

Sponsor Role collaborator

Rhode Island Hospital

OTHER

Sponsor Role lead

Principal Investigators

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Judith Owens, MD, MPH

Role: PRINCIPAL_INVESTIGATOR

Rhode Island Hospital

Locations

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Rhode Island Hospital

Providence, Rhode Island, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Gloria Velez, B.A.

Role: CONTACT

Phone: 401-444-3250

Email: [email protected]

Juhee Lee, B.A.

Role: CONTACT

Phone: 401-444-8815

Email: [email protected]

Other Identifiers

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0120-05

Identifier Type: -

Identifier Source: org_study_id