Study Evaluating Bazedoxifene/Conjugated Estrogens Combinations In Postmenopausal Women

NCT ID: NCT00242710

Last Updated: 2013-12-20

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

1083 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-09-30

Study Completion Date

2008-09-30

Brief Summary

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The purpose of this study is to determine whether bazedoxifene/conjugated estrogens combinations are effective for the prevention of endometrial hyperplasia and for the prevention of osteoporosis in postmenopausal women.

Detailed Description

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Conditions

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Endometrial Hyperplasia Osteoporosis

Keywords

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Endometrium Uterus Menopause

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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1

BZA 20mg/CE 0.625

Group Type EXPERIMENTAL

Bazedoxifene/Conjugated Estrogen

Intervention Type DRUG

Subjects will take 1 capsule orally, once daily, at approximately the same time each day continuously for the duration of the study.

Arm 2

BZA 20mg/CE 0.45

Group Type EXPERIMENTAL

Bazedoxifene/Conjugated Estrogen

Intervention Type DRUG

Subjects will take 1 capsule orally, once daily, at approximately the same time each day continuously for the duration of the study.

Arm 3

CE 0.45mg/MPA1.5mg

Group Type ACTIVE_COMPARATOR

CE 0.45 mg/MPA 1.5mg

Intervention Type DRUG

Subjects will take 1 capsule orally, once daily, at approximately the same time each day continuously for the duration of the study.

Arm 4

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

Subjects will take 1 capsule orally, once daily, at approximately the same time each day continuously for the duration of the study.

Interventions

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Bazedoxifene/Conjugated Estrogen

Subjects will take 1 capsule orally, once daily, at approximately the same time each day continuously for the duration of the study.

Intervention Type DRUG

Bazedoxifene/Conjugated Estrogen

Subjects will take 1 capsule orally, once daily, at approximately the same time each day continuously for the duration of the study.

Intervention Type DRUG

CE 0.45 mg/MPA 1.5mg

Subjects will take 1 capsule orally, once daily, at approximately the same time each day continuously for the duration of the study.

Intervention Type DRUG

Placebo

Subjects will take 1 capsule orally, once daily, at approximately the same time each day continuously for the duration of the study.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Generally healthy, postmenopausal women, aged 40 to less than 65 years
* Intact uterus
* At least 12 months of spontaneous amenorrhea, OR 6 months spontaneous amenorrhea with follicle-stimulating hormone (FSH) levels \> 40 mIU/mL.

Exclusion Criteria

* Use of oral estrogen-, progestin-, androgen-, or SERM-containing drug products within 8 weeks before screening (12 weeks for the osteoporosis substudy)
* A history or active presence of clinically important medical disease
* Malabsorption disorders
Minimum Eligible Age

40 Years

Maximum Eligible Age

65 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Pfizer Investigational Site

Upland, California, United States

Site Status

Pfizer Investigational Site

Inverness, Florida, United States

Site Status

Pfizer Investigational Site

West Palm Beach, Florida, United States

Site Status

Pfizer Investigational Site

Decatur, Georgia, United States

Site Status

Pfizer Investigational Site

Honolulu, Hawaii, United States

Site Status

Pfizer Investigational Site

Lexington, Kentucky, United States

Site Status

Pfizer Investigational Site

Billings, Montana, United States

Site Status

Pfizer Investigational Site

Eugene, Oregon, United States

Site Status

Pfizer Investigational Site

Pittsburgh, Pennsylvania, United States

Site Status

Countries

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United States

Related Links

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Other Identifiers

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3115A1-304

Identifier Type: -

Identifier Source: org_study_id