Immune Responses to BCG Vaccination in Malawi and the UK

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Study Classification

INTERVENTIONAL

Brief Summary

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BCG vaccination has been found to provide greater protection against TB in the UK than in Malawi. This study compares immune responses in BCG-vaccinated and unvaccinated teenagers and young adults in Malawi and in the UK.

Detailed Description

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Conditions

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Immunity, Cellular Hypersensitivity, Delayed Type

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Interventions

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BCG

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* BCG unvaccinated
* HIV negative
* Not pregnant
* Informed Consent

Exclusion Criteria

* HIV positive
* Pregnant
* Seriously ill

Minimum Eligible Age

12 Years

Maximum Eligible Age

25 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Principal Investigators

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Paul EM Fine, VMD, PhD

Role: PRINCIPAL_INVESTIGATOR

London School of Hygiene and Tropical Medicine

Locations

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Karonga Prevention Study

Chilumba, Karonga District, Malawi

Site Status

Redbridge and Waltham Forest Primary Care Trust

Ilford, Essex, United Kingdom