Cordis Bilateral AAA Device Compared to Open Surgical Repair of Abdominal Aortic Aneurysms (ARIBA)

NCT ID: NCT00235118

Last Updated: 2005-12-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1/PHASE2

Total Enrollment

29 participants

Study Classification

INTERVENTIONAL

Study Start Date

1999-12-31

Study Completion Date

2006-02-28

Brief Summary

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The objective of this study is to assess the safety and effectiveness of the Cordis Bilateral AAA device and its Delivery System compared to open surgical repair for the treatment of Abdominal Aortic Aneurysm (AAA).

Detailed Description

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Conditions

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Abdominal Aortic Aneurysm

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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Cordis AAA Bilateral Device

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

\- Anatomic (stent-graft)

Aortic Aneurysm Diameter

* \> 4.5 cm
* Those aortic aneurysms \< 4.5 cm that are at least 1.5 times the diameter of the aorta with a size increase of 5 mm or greater over a six month period will also be included for possible treatment.
* Aorto-iliac aneurysms in which the aortic aneurysm is \< 4.5 cm but the iliac artery aneurysms are \> 3.0 cm in diameter or there is evidence of recent expansion (5 mm or greater over a six month period) in iliac aneurysms \< 3.0 cm.
* Saccular aortic aneurysms \> 3.0 cm.

Aortic Neck

* Diameter \> 17 mm and \< 28 mm (Phase I)
* Diameter \> 14 mm and \< 28 mm (Phase II)

Angulation Neck Length \< 45° \> 15 mm \<60° \> 25 mm

Iliac Arteries

* Diameter \> 8 mm and \< 18 mm (Phase I and Phase II)
* At least one common iliac artery with a cuff \> 15 mm.

Diameter Aortic Neck Common Iliac 26-28 mm 13-18 mm 23-25.9 mm 10-17 mm 20-22.9 mm 9-15 mm 17-19.9 mm 8-13 mm 14-16.9 mm 8-11mm

\*NOTE: An aortic diameter cannot be treated if the iliac diameter is not in the same range (e.g. 26-28 mm aortic necks must be in conjunction with 13-18 mm common iliacs).

Anatomic (surgical controls)


Aortic Aneurysm Diameter

* \> 4.5 cm
* Those aortic aneurysms \<4.5 cm that are at least 1.5 times the diameter of the aorta with a size increase of 5 mm or greater over a six month period will also be included for possible treatment.
* Aorto-iliac aneurysm in which the aortic aneurysm is \<4.5 cm but the iliac artery aneurysm are \>3.0 cm in diameter or there is evidence of recent expansion (5 mm or greater over a six month period) in iliac aneurysms \<3.0 cm.
* Saccular aortic aneurysms \> 3.0 cm.
* Clinical (stent-graft)
* Males and non-pregnant females \> 40 years of age.
* Clinical (surgical controls)



Iliac Arteries

* \< 8 mm and \> 18 mm (native) (Phase I and Phase II)
* Highly calcified (common)
* Neither common iliac artery with a cuff \> 15 mm.


Anatomic (surgical controls)

Exclusion Criteria

Anatomic (stent-graft)

Aortic Aneurysm Diameter

· \< 4.5 cm that are not at least 1.5 times the diameter of the aorta with evidence of a size increase of 5 mm or greater within a six month period.

Aorto-iliac Aneurysms

* \< 3.0 cm in diameter unless evidence of recent expansion (5 mm or greater within a six month period).
* The iliac portion of the aneurysm extending to the bifurcation bilaterally which would necessitate covering both internal iliac arteries with the device.

Aortic Neck

* Diameter \< 17 mm and \> 28 mm (Phase I)
* Diameter \< 14 and \>28 (Phase II)
* Thrombus lined
* Highly calcified


Aortic Aneurysm Diameter

· \< 4.5 cm that are not at least 1.5 times the diameter of the aorta with evidence of a size increase of 5 mm or greater within a six month period.

Aorto-Iliac Aneurysms

* \< 3.0 cm in diameter unless evidence of recent expansion (5 mm or greater within a six month period).
* The iliac portion of the aneurysm extending to the bifurcation bilaterally which would necessitate surgically covering both internal iliac arteries.

Clinical (stent-graft)

1. Ruptured abdominal aortic aneurysm.
2. Renal insufficiency - creatinine level \> 2.5 mg/dl.
Minimum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Cordis Corporation

INDUSTRY

Sponsor Role lead

Principal Investigators

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Michael Marin, MD

Role: PRINCIPAL_INVESTIGATOR

MOUNT SINAI HOSPITAL

Locations

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Mt. Sinai Hospital

New York, New York, United States

Site Status

Countries

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United States

Other Identifiers

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P98-4601

Identifier Type: -

Identifier Source: org_study_id