Study to Assess Satisfaction With Modafinil Treatment in Children and Adolescents With ADHD

NCT ID: NCT00228540

Last Updated: 2014-05-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Study Classification

INTERVENTIONAL

Study Start Date

2005-09-30

Study Completion Date

2006-09-30

Brief Summary

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An 8-week, Open-Label Study to Characterize the Response to Modafinil (85mg Film-Coated Tablet) Treatment at Dosages up to 425mg/Day in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder (ADHD) (With an Open-Ended Extension Period)

Detailed Description

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Conditions

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ADHD

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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Modafinil

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

Patients are included in the study if all of the following criteria are met:

* Written informed consent/assent is obtained.
* The patient is a boy or girl 6 through 17 years of age (inclusive) at the screening visit, and both the patient and parent/legal guardian are English-speaking.
* The patient has a previous diagnosis of ADHD and is currently receiving medication for the treatment of ADHD.
* The patient, or the patient's parent/legal guardian, is dissatified (VAS score \<50) with current ADHD medication (medication and reason for dissatisfaction documented).
* The patient is in good health as determined by a medical or psychiatric history, screening physical examination, and clinical laboratory evaluations.
* Girls who are postmenarche or sexually active, must have a negative urine pregnancy test prior to the baseline visit, must be using a medically acceptable method of birth control, and must agree to continue use of this method for the duration of the study (and for 30 days after participation in the study). Acceptable methods of birth control include the following: barrier method with spermicide; steroidal contraceptive (eg, oral, transdermal, implant, or injected) in conjunction with a barrier method; intrauterine device (IUD); and abstinence.
* The patient's parent/legal guardian must be willing and able to comply with study procedures and restrictions.

Exclusion Criteria

Patients are excluded from participating in this study if 1 or more of the following criteria are met:

* The patient has any current psychiatric comorbidity, including but not limited to depression or other mood disorder, or pervasive mental disorder, that requires pharmacotherapy.
* The patient is satisfied with current ADHD medication and has no side effects.
* The patient is using other prescription medications for ADHD with psychoactive properties (eg, amphetamine, dextroamphetamine, methylphenidate, pemoline, atomoxetine) after the baseline visit.
* The patient has used monoamine oxidase (MAO) inhibitors within 1 week before the baseline visit.
* The patient has used an investigational drug within 1 month before the screening visit.
* The patient has a known clinically significant drug sensitivity to modafinil or any of its inactive ingredients.
* The patient is pregnant or lactating. (Any patients becoming pregnant during the study will be withdrawn from study).
Minimum Eligible Age

6 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Cephalon

INDUSTRY

Sponsor Role lead

Locations

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Melmed Center

Scottsdale, Arizona, United States

Site Status

UCI Child Development Center

Irvine, California, United States

Site Status

Pharmacology Research Institut

Northridge, California, United States

Site Status

Pacific Sleep Medicine Service

San Diego, California, United States

Site Status

Sarkis Clinical Trials

Gainesville, Florida, United States

Site Status

Clinical Neuroscience Solution

Jacksonville, Florida, United States

Site Status

Clinical Neurosciences

Orlando, Florida, United States

Site Status

Laszlo J. Mate, MD, PA

West Palm Beach, Florida, United States

Site Status

Northwest Behavioral Research

Marietta, Georgia, United States

Site Status

Pediatrics and Adolescent

Woodstock, Georgia, United States

Site Status

Loyola University Medical Center Department of Psychiatry

Maywood, Illinois, United States

Site Status

HALP Clinic and ADHD Research

Northbrook, Illinois, United States

Site Status

Cientifica, Inc.

Wichita, Kansas, United States

Site Status

Michael J. Rieser, MD

Lexington, Kentucky, United States

Site Status

Pedia Research, LLC

Owensboro, Kentucky, United States

Site Status

Louisiana Research Associates

New Orleans, Louisiana, United States

Site Status

Psycopharmacology Research - LSU Health Science Center

Shreveport, Louisiana, United States

Site Status

Massachusetts General Hospital

Cambridge, Massachusetts, United States

Site Status

Odyssey Research

Dearborn, Michigan, United States

Site Status

Hurley Medical Center

Flint, Michigan, United States

Site Status

ProMed HealthCare

Kalamazoo, Michigan, United States

Site Status

Regions Hospital

Saint Paul, Minnesota, United States

Site Status

Odyssey Research

McCook, Nebraska, United States

Site Status

University of Nebraska

Omaha, Nebraska, United States

Site Status

Bancroft Clinical Research

Cherry Hill, New Jersey, United States

Site Status

Hunterdon Pediatric Associates

Flemington, New Jersey, United States

Site Status

Odyssey Research

Bismarck, North Dakota, United States

Site Status

Prairie at Saint John's

Fargo, North Dakota, United States

Site Status

Odyssey Research

Minot, North Dakota, United States

Site Status

Cincinnati Children's Hospital

Cincinnati, Ohio, United States

Site Status

OCCI, Inc Salem

Salem, Oregon, United States

Site Status

Medical University of SC

Charleston, South Carolina, United States

Site Status

UT Medical Group

Memphis, Tennessee, United States

Site Status

Clinical Neuroscience Solution

Memphis, Tennessee, United States

Site Status

Claghorn-Lesem Research

Bellaire, Texas, United States

Site Status

The Clinical Study Ceneter

Burlington, Vermont, United States

Site Status

Dominion Clinical Research

Midlothian, Virginia, United States

Site Status

Advanced Pediatrics

Vienna, Virginia, United States

Site Status

Eastside Therapeutic Resource

Kirkland, Washington, United States

Site Status

Countries

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United States

Other Identifiers

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C1538/3044/AD/US

Identifier Type: -

Identifier Source: org_study_id

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