Microbubbles and Ultrasound in Stroke Trial: MUST Study
NCT ID: NCT00222040
Last Updated: 2010-04-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
PHASE2
20 participants
INTERVENTIONAL
2004-06-30
2004-06-30
Brief Summary
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Detailed Description
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Early recanalization is assessed using MR or CT angiography 4 to 8 hours after symptom onset. The evaluation of angiograms is performed by 2 neuroradiologists blinded to group of randomization and clinical details. The primary outcome measure is the rate of early recanalization. Recanalization is assessed using the TIMI classification. Secondary endpoints include the rate of symptomatic intracerebral hemorrhage, mortality, and functional outcome on the modified Rankin scale at 3 months.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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1
Levovist
Ultrasound
2-MHz, low intensity transcranial ultrasound
Levovist
D-Galactose and palmitic palmitique intravenous 4 g
2
No specific intervention
No interventions assigned to this group
Interventions
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Ultrasound
2-MHz, low intensity transcranial ultrasound
Levovist
D-Galactose and palmitic palmitique intravenous 4 g
Eligibility Criteria
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Inclusion Criteria
* MCA proximal occlusion on CT or MR angiography
* Thrombolysis with intravenous alteplase initiated within 3 hours of stroke onset
18 Years
80 Years
ALL
No
Sponsors
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Ministry of Health, France
OTHER_GOV
University Hospital, Toulouse
OTHER
Responsible Party
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University Hospital Toulouse
Principal Investigators
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LARRUE Vincent, MD
Role: PRINCIPAL_INVESTIGATOR
University Hospital, Toulouse, France
Locations
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Service de Neurologie
Besançon, , France
Service de Neurologie, Hôpital Gui de Chauliac
Montpellier, , France
Service de Neurologie, Hôpital Sainte Anne
Paris, , France
Service de Neurologie Vasculaire, University Hospital
Toulouse, , France
Service de Neurologie, University Hospital
Tours, , France
Countries
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References
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Cintas P, Le Traon AP, Larrue V. High rate of recanalization of middle cerebral artery occlusion during 2-MHz transcranial color-coded Doppler continuous monitoring without thrombolytic drug. Stroke. 2002 Feb;33(2):626-8. doi: 10.1161/hs0202.103073.
Cintas P, Nguyen F, Boneu B, Larrue V. Enhancement of enzymatic fibrinolysis with 2-MHz ultrasound and microbubbles. J Thromb Haemost. 2004 Jul;2(7):1163-6. doi: 10.1111/j.1538-7836.2004.00746.x.
Viguier A, Petit R, Rigal M, Cintas P, Larrue V. Continuous monitoring of middle cerebral artery recanalization with transcranial color-coded sonography and Levovist. J Thromb Thrombolysis. 2005 Feb;19(1):55-9. doi: 10.1007/s11239-005-0940-6.
Other Identifiers
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0302208
Identifier Type: -
Identifier Source: org_study_id