L-arginine Supplementation and Exercise; L-arginine Supplementation and Renal Function
NCT ID: NCT00213915
Last Updated: 2025-12-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
30 participants
INTERVENTIONAL
2004-02-29
2004-12-31
Brief Summary
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* cyclosporin-induced renal dysfunction may be due to renal endothelial dysfunction and can be reversed in an animal model by L-arginine supplementation
* to determine the potential beneficial effect of L-arginine supplementation on exercise capacity and renal function of heart transplant recipients
Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Interventions
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12 g of L-arginine glutamate during 6 weeks twice a day
Eligibility Criteria
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Inclusion Criteria
* Stable treatment for at least 3 months
* Sedentary people
Exclusion Criteria
* Obesity (IMC \> 40)
* Participation in another study in the last month
* Chronic renal failure (creatinine clearance \< 20 ml/min)
* Renal transplantation
* Diabetes
* Impossibility to practice exercise test
* Nitrate therapy
18 Years
ALL
No
Sponsors
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University Hospital, Strasbourg, France
OTHER
Responsible Party
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Principal Investigators
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Stephane DOUTRELEAU, MD
Role: PRINCIPAL_INVESTIGATOR
Service de Physiologie et d'Explorations Fonctionnelles
Locations
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Institut de Physiologie
Strasbourg, , France
Service de Chirurgie Vasculaire
Strasbourg, , France
Service des Explorations Fonctionnelles Respiratoires et de l'Exercice
Strasbourg, , France
Countries
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References
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Doutreleau S, Rouyer O, Di Marco P, Lonsdorfer E, Richard R, Piquard F, Geny B. L-arginine supplementation improves exercise capacity after a heart transplant. Am J Clin Nutr. 2010 May;91(5):1261-7. doi: 10.3945/ajcn.2009.27881. Epub 2010 Mar 3.
Other Identifiers
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3031
Identifier Type: -
Identifier Source: org_study_id