Evaluation of Iron Supplementation During Darbepoetin Alfa Treatment in Prophylaxis of Severe Anaemia Chemo-Induced

NCT ID: NCT00210002

Last Updated: 2006-11-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE2

Total Enrollment

55 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-11-30

Study Completion Date

2006-04-30

Brief Summary

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The purpose of this study is to evaluate the response rate obtained in an heterogeneous oncologic population treated by chemotherapy, and either by Darbepoetin alfa classic treatment or by association of Darbepoetin alfa -ferric saccharose systematic supplementation, administered concomitantly with chemotherapy.

Detailed Description

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Conditions

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Neoplasms Anemia

Keywords

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Neoplasms Solid Anemia darbepoetin alfa ferric saccharose Venofer® Aranesp®

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Interventions

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Darbepoetin alfa (Aranesp®)

Intervention Type DRUG

Ferric saccharose(Venofer®)

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Age ≥ 18 years
* Well-informed written consent, signed by the patient
* Patient picked up for solid tumor treatment, whichever the localization, with or without metastasis
* Patient revealing, before or during chemotherapy, a moderate anemia, that means: Men: 9\<Hb\<12 g/dl; Women: 9\<Hb\<11 g/dl.
* Patient for who at least four chemotherapy cycles are planed (eight in case of weekly chemotherapy) after inclusion in the study
* Patients with life expectancy higher than three months
* Patient with general conditions compatible with the study's follow-up

Exclusion Criteria

* Contra-indication for Venofer
* Anemia which can have curative treatment
* Bloody transfusion during the previous four weeks
* Documented or suspected medullary invasion
* Uncontrolled arterial hypertension
* Acute bacterial infection
* Transferrin saturation's coefficient
* Pregnancy
* Ferric salts oral treatment interrupted since less than one week
* Patient with bad french language's comprehension
* Patient with a major psychiatric pathology
* Patient under guardianship, trusteeship or justice safeguard
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Institut Claudius Regaud

OTHER

Sponsor Role lead

Principal Investigators

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Roland Dugat, Pr

Role: PRINCIPAL_INVESTIGATOR

Institut Claudius Regaud

Locations

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Centre Hospitalier de Castres

Castres, , France

Site Status

Centre Hospitalier de Montauban

Montauban, , France

Site Status

Centre Hospitalier Joseph Ducuing

Toulouse, , France

Site Status

Institut Claudius Regaud

Toulouse, , France

Site Status

Countries

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France

Other Identifiers

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03 DIVE 01

Identifier Type: -

Identifier Source: org_study_id