Head and Neck Phase III Iressa Versus Methotrexate Refractory: Iressa Versus Methotrexate (IMEX)

NCT ID: NCT00206219

Last Updated: 2011-01-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

477 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-11-30

Study Completion Date

2007-09-30

Brief Summary

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This study is to compare ZD1839 (250mg and 500mg) versus methotrexate in head and neck cancer in terms of overall survival.

Detailed Description

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Conditions

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Squamous Cell Carcinoma of the Head and Neck

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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Gefitinib

Intervention Type DRUG

methotrexate

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Histological confirmation of evidence of squamous cell carcinoma of the head and neck.
* Tumors have progressed after primary treatment with radiation or chemoradiation and have failed to respond to at least one course of standard platinum-based chemotherapy.
* Tumors have progressed after primary treatment with radiation or chemoradiation and are considered unsuitable for platinum-based chemotherapy.

Exclusion Criteria

* Carcinomas of the post-nasal space, thyroid, sinus or salivary gland tumors.
* Isolated recurrent disease that may be amenable to local therapy; e.g., surgical intervention or radiation therapy.
* Known severe hypersensitivity to ZD1839, Methotrexate or any of the excipients of these products.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AstraZeneca

INDUSTRY

Sponsor Role lead

Principal Investigators

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AstraZeneca Iressa Medical Science Director, MD

Role: STUDY_DIRECTOR

AstraZeneca

Locations

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Birmingham, Alabama, United States

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Tucson, Arizona, United States

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Palm Springs, California, United States

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Aurora, Colorado, United States

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New Haven, Connecticut, United States

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Norwalk, Connecticut, United States

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Miami, Florida, United States

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Orlando, Florida, United States

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Ormand Beach, Florida, United States

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Savannah, Georgia, United States

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Chicago, Illinois, United States

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Des Moines, Iowa, United States

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Louisville, Kentucky, United States

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Baton Rouge, Louisiana, United States

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Waterville, Maine, United States

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Bethesda, Maryland, United States

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Detroit, Michigan, United States

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Omaha, Nebraska, United States

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Hackensack, New Jersey, United States

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Brooklyn, New York, United States

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New York, New York, United States

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Oklahoma City, Oklahoma, United States

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Philadelphia, Pennsylvania, United States

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Norfolk, Virginia, United States

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Olympia, Washington, United States

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Milwaukee, Wisconsin, United States

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Capital Federal, Buenos Aires, Argentina

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El Palomar, Buenos Aires, Argentina

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Salta, Salta Province, Argentina

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Santa Fe, Santa Fe Province, Argentina

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Westmead, New South Wales, Australia

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Brussels, , Belgium

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Brussels (Woluwé-St-Lambert), , Belgium

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Edegem, , Belgium

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Ghent, , Belgium

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Haine-Saint-Paul, , Belgium

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Goiânia, Goiás, Brazil

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Rio de Janeiro, Rio de Janeiro, Brazil

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São Paulo, São Paulo, Brazil

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Vancouver, British Columbia, Canada

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Winnipeg, Manitoba, Canada

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Halifax, Nova Scotia, Canada

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London, Ontario, Canada

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Windsor, Ontario, Canada

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Montreal, Quebec, Canada

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Zagreb, , Croatia

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Brno, , Czechia

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Ostrava, , Czechia

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Ostrava - Poruba, , Czechia

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Prague, , Czechia

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Tallinn, , Estonia

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Tartu, , Estonia

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Thessaloniki, , Greece

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Kochi, Kerala, India

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Thiruvananthapuram, Kerala, India

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Bhopal, Madhya Pradesh, India

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Pune, Maharashtra, India

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Ansārinagar, New Dehli, India

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Jaipur, Rajasthan, India

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Kolkata, West Bengal, India

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New Dehli, , India

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Petah Tikva, , Israel

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Tel Litwinsky, , Israel

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Bologna, , Italy

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Cuneo, , Italy

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Forlì, , Italy

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Genova, , Italy

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Milan, , Italy

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Napoli, , Italy

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Roma, , Italy

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Torino, , Italy

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Riga, , Latvia

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Klaipėda, , Lithuania

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Vilnius, , Lithuania

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Kampung Baharu Nilai, , Malaysia

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Petaling Jaya, , Malaysia

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Amsterdam, , Netherlands

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Maastricht, , Netherlands

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Nijmegen, , Netherlands

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Utrecht, , Netherlands

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Oslo, , Norway

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Krasnogorsk, , Russia

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Moscow, , Russia

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Saint Petersburg, , Russia

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Zaloska, Ljubljana, Slovenia

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Ljubljana, , Slovenia

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Bloemfontein, , South Africa

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Cape Town, , South Africa

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Durban, , South Africa

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Johannesburg, , South Africa

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Pretoria, , South Africa

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Tygerberg, , South Africa

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Santiago de Compostela, A Coruña, Spain

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Granada, Granada, Spain

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Leganés, Madrid, Spain

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Madrid, Madrid, Spain

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Pontevedra, Pontevedra, Spain

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Valencia, Valencia, Spain

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Barakaldo, Vizcaya, Spain

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Santander, , Spain

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Valencia, , Spain

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Vitoria-Gasteiz, Álava, Spain

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Gothenburg, , Sweden

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Malmo, , Sweden

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Stockholm, , Sweden

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Bangkok, , Thailand

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Chiang Mai, , Thailand

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Leeds, , United Kingdom

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London, , United Kingdom

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Countries

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United States Argentina Australia Belgium Brazil Canada Croatia Czechia Estonia Greece India Israel Italy Latvia Lithuania Malaysia Netherlands Norway Russia Slovenia South Africa Spain Sweden Thailand United Kingdom

Other Identifiers

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EudraCT no.2004-002662-38

Identifier Type: -

Identifier Source: secondary_id

1839IL/0704

Identifier Type: -

Identifier Source: org_study_id

NCT00072878

Identifier Type: -

Identifier Source: nct_alias

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