Comparison of the Two Immunosuppressive Regimens Based on Tacrolimus and Cyclosporine Following Kidney Transplantation

NCT ID: NCT00204191

Last Updated: 2007-10-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE4

Total Enrollment

300 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-05-31

Study Completion Date

2007-12-31

Brief Summary

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The purpose of this study is to evaluate and compare, in the single center setting, the safety, efficacy and cost-effectiveness of the two standard immunosuppressive regimens based on tacrolimus and cyclosporine.

Detailed Description

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Despite several multicenter studies, there is no hard evidence on the superiority of a cyclosporine or tacrolimus based immunosuppressive regimen following kidney transplantation, in a single-center setting. Existing studies concentrated on benefits in safety and efficacy, but seldomly evaluated the cost-effectiveness of one treatment.

The study has been designed in a fashion as close to the daily clinical practice as possible. Patients are randomized in pairs, receiving kidneys from the same donor, thus avoiding donor-related bias. Those having specific indications or contraindications for one of the study medications were not entered into the study. All other study-related decisions are made only on a clinical basis and according to the standard practice of the center. Patients are followed on the intention-to-treat rule. Cost-effectiveness will be calculated on 12-month treatment for each patient entered into the study.

Conditions

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Kidney Transplantation

Keywords

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kidney transplantation Immunosuppression Cyclosporine Tacrolimus

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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tacrolimus

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* First or second cadaveric kidney transplantation
* Age over 18 years old
* Specific indications or contraindications for cyclosporine or tacrolimus are absent
* Informed consent

Exclusion Criteria

* Specific indications for use of cyclosporine or tacrolimus
* Specific contraindications for use of cyclosporine or tacrolimus
* Participation in another interventional clinical trial
* Pregnancy or lactation
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Astellas Pharma Inc

INDUSTRY

Sponsor Role collaborator

Uniwersytet Mikolaja Kopernika w Toruniu

OTHER

Sponsor Role lead

Principal Investigators

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Zbigniew Wlodarczyk, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Klinika Transplantologii, Collegium Medicum UMK Torun

Locations

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Klinika Transplantologii, Szpital Uniwersytecki, ul. M. Sklodowskiej-Curie 9

Bydgoszcz, , Poland

Site Status RECRUITING

Countries

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Poland

Central Contacts

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Zbigniew Wlodarczyk, MD, PhD

Role: CONTACT

Phone: +48 52 585 4044

Email: [email protected]

Other Identifiers

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IDS PL-02-RG-122

Identifier Type: -

Identifier Source: secondary_id

1/25/03

Identifier Type: -

Identifier Source: org_study_id