Trial Outcomes & Findings for Identifying the Anti-Blood-Clotting Compounds in Garlic (NCT NCT00200785)

NCT ID: NCT00200785

Last Updated: 2010-01-11

Results Overview

percent platelet aggregation in collagen-induced platelet aggregation in platelet rich plasma (PRP)

Recruitment status

COMPLETED

Study phase

Target enrollment

9 participants

Primary outcome timeframe

4 weeks

Results posted on

2010-01-11

Participant Flow

healthy participants were recruited in Utah county, Utah, in early 2006

Participant milestones

Participant milestones
Measure	Garlic Powder: High Allicin garlic powder in ambient water	Garlic Powder: No Allicin garlic powder in boiling water
First Intervention STARTED	9	6
First Intervention COMPLETED	9	6
First Intervention NOT COMPLETED	0	0
Washout Period of 1 Week STARTED	9	6
Washout Period of 1 Week COMPLETED	9	6
Washout Period of 1 Week NOT COMPLETED	0	0
Second Intervention STARTED	9	6
Second Intervention COMPLETED	9	6
Second Intervention NOT COMPLETED	0	0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Identifying the Anti-Blood-Clotting Compounds in Garlic

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Garlic Powder: High Allicin n=9 Participants garlic powder in ambient water	Garlic Powder: No Allicin n=6 Participants garlic powder in boiling water	Total n=15 Participants Total of all reporting groups
Age, Categorical <=18 years	0 Participants n=5 Participants	0 Participants n=7 Participants	0.0 Participants n=5 Participants
Age, Categorical Between 18 and 65 years	9 Participants n=5 Participants	6 Participants n=7 Participants	15.0 Participants n=5 Participants
Age, Categorical >=65 years	0 Participants n=5 Participants	0 Participants n=7 Participants	0.0 Participants n=5 Participants
Age Continuous	32.2 years STANDARD_DEVIATION 13.7 • n=5 Participants	36.5 years STANDARD_DEVIATION 15.1 • n=7 Participants	32.2 years STANDARD_DEVIATION 13.7 • n=5 Participants
Sex: Female, Male Female	4 Participants n=5 Participants	3 Participants n=7 Participants	7.0 Participants n=5 Participants
Sex: Female, Male Male	5 Participants n=5 Participants	3 Participants n=7 Participants	8.0 Participants n=5 Participants
Region of Enrollment United States	9 participants n=5 Participants	6 participants n=7 Participants	15.0 participants n=5 Participants
electrical impedance (ohms) at 0 weeks	12.7 ohms STANDARD_DEVIATION 1.2 • n=5 Participants	15.0 ohms STANDARD_DEVIATION 1.6 • n=7 Participants	13.9 ohms STANDARD_DEVIATION 1.4 • n=5 Participants
percent platelet aggregation at 0 weeks	76.0 percent platelet aggregation STANDARD_DEVIATION 1.6 • n=5 Participants	71.8 percent platelet aggregation STANDARD_DEVIATION 5.7 • n=7 Participants	73.9 percent platelet aggregation STANDARD_DEVIATION 3.7 • n=5 Participants

PRIMARY outcome

Timeframe: 4 weeks

percent platelet aggregation in collagen-induced platelet aggregation in platelet rich plasma (PRP)

Outcome measures

Outcome measures
Measure	Garlic Powder: High Allicin n=9 Participants garlic powder in ambient water	Garlic Powder: No Allicin n=6 Participants garlic powder in boiling water
Percent Platelet Aggregation	71.4 percent platelet aggregation Standard Deviation 4.3	72.5 percent platelet aggregation Standard Deviation 5.5

SECONDARY outcome

Timeframe: 4 weeks

Population: Nine persons participated in the "high allicin" test. Six of the same persons participated in the "no allicin" test.

Electrical impedance (ohms) was measured using 0.5 mL of whole blood plus 0.5 mL saline in a Chronolog Whole Blood aggregometer. Ten mL of whole blood were collected and tested every week. There is no mathematical correlation between impedance (ohms) and percent aggregation.

Outcome measures

Outcome measures
Measure	Garlic Powder: High Allicin n=9 Participants garlic powder in ambient water	Garlic Powder: No Allicin n=6 Participants garlic powder in boiling water
Electrical Impedance in Ohms	13.8 ohms Standard Deviation 1.5	15.0 ohms Standard Deviation 1.5

Adverse Events

Garlic Powder: High Allicin

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Garlic Powder: No Allicin

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Larry D. Lawson

Silliker, Inc./Plant Bioactives Research Institute, Inc.

Phone: 801-226-3041

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place