Study Evaluating Etanercept in the Treatment of Subjects With Psoriasis

NCT ID: NCT00195507

Last Updated: 2013-02-25

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

720 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-12-31

Study Completion Date

2007-02-28

Brief Summary

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This study will provide a direct comparison of 'continuous therapy' and 'intermittent therapy' with withdrawal and retreatment upon return of psoriasis.

Detailed Description

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Conditions

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Psoriasis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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Etanercept

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Stable, active plaque psoriasis
* Failure to respond to the following systemic therapies: Methotrexate, Cyclosporine, PUVA or Fumarate

Exclusion Criteria

* Evidence of skin conditions other than psoriasis that would interfere with evaluations of the effect of the study
* Systemic psoriasis therapy within 28 days prior
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Wyeth is now a wholly owned subsidiary of Pfizer

INDUSTRY

Sponsor Role lead

Principal Investigators

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Medical Monitor

Role: STUDY_DIRECTOR

Wyeth is now a wholly owned subsidiary of Pfizer

Trial Manager

Role: PRINCIPAL_INVESTIGATOR

For Italy,Greece, [email protected]

Trial Manager

Role: PRINCIPAL_INVESTIGATOR

For Denmark, Finland, Sweden, Norway, [email protected]

TRial manager

Role: PRINCIPAL_INVESTIGATOR

For Belgium, [email protected]

Trial Manager

Role: PRINCIPAL_INVESTIGATOR

For Austria, [email protected]

Trial Manager

Role: PRINCIPAL_INVESTIGATOR

For Netherlands, [email protected]

Trial Manager

Role: PRINCIPAL_INVESTIGATOR

For Hungary, [email protected]

Trial Manager

Role: PRINCIPAL_INVESTIGATOR

For Turkey, [email protected]

Trial Manager

Role: PRINCIPAL_INVESTIGATOR

For Poland, [email protected]

Trial Manager

Role: PRINCIPAL_INVESTIGATOR

For Germany, [email protected]

Trial Manager

Role: PRINCIPAL_INVESTIGATOR

For UK, [email protected]

Locations

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Feldkirch, , Austria

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Vienna, , Austria

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Vienna, , Austria

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Brussels, , Belgium

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Brussels, , Belgium

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Edegem, , Belgium

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Ghent, , Belgium

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Leuven, , Belgium

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Liège, , Belgium

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Prague, , Czechia

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Aarhus C, , Denmark

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Odense C, , Denmark

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Roskilde, , Denmark

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Kuopio, , Finland

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Lahti, , Finland

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Besançon, , France

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Bordeaux, , France

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Boulogne-Billancourt, , France

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Brest, , France

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Créteil, , France

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Dijon, , France

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Lille, , France

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Lyon, , France

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Lyon, , France

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Marseille, , France

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Marseille Cédex 09, , France

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Montpellier Cédex 5, , France

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Nancy, , France

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Nantes, , France

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Nice, , France

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Nîmes, , France

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Paris, , France

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Pessac, , France

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Pierre-Bénite, , France

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Poitiers, , France

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Reims, , France

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Rouen, , France

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Saint-Etienne, , France

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Strasbourg, , France

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Toulouse, , France

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Tours, , France

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Bochum, , Germany

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Düsseldorf, , Germany

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Erlangen, , Germany

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Essen, , Germany

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Frankfurt, , Germany

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Hamburg, , Germany

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Kiel, , Germany

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Leipzig, , Germany

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Magdeburg, , Germany

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Mainz, , Germany

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Münster, , Germany

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Nordheide, , Germany

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Osnabrück, , Germany

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Tübingen, , Germany

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Würzburg, , Germany

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Athens, , Greece

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Athens, , Greece

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Thessaloniki, , Greece

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Budapest, , Hungary

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Ancona, , Italy

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Cagliari, , Italy

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Genova, , Italy

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Modena, , Italy

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Padua, , Italy

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Pavia, , Italy

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Roma, , Italy

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Roma, , Italy

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Roma, , Italy

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Terni, , Italy

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Torino, , Italy

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Amsterdam, , Netherlands

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Amsterdam, , Netherlands

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Capelle aan den IJssel, , Netherlands

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Heerlen, , Netherlands

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Nijmegen, , Netherlands

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Rotterdam, , Netherlands

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Utrecht, , Netherlands

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Voorburg, , Netherlands

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Bergen, , Norway

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Oslo, , Norway

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Stavanger, , Norway

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Warsaw, , Poland

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Lisbon, , Portugal

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Lisbon, , Portugal

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Barcelona, , Spain

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Bilbao, , Spain

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Llobregat, , Spain

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Madrid, , Spain

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Madrid, , Spain

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Madrid, , Spain

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Málaga, , Spain

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Valencia, , Spain

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Danderyds, , Sweden

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Gothenburg, , Sweden

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Linköping, , Sweden

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Lund, , Sweden

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Stockholm, , Sweden

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Umeå, , Sweden

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Basel, , Switzerland

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Bern, , Switzerland

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Geneva, , Switzerland

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Bornova-Izmir, , Turkey (Türkiye)

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Capa-Istanbul, , Turkey (Türkiye)

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Kocamustafapasa-Istanbul, , Turkey (Türkiye)

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Aberdeen, , United Kingdom

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Airdrie, , United Kingdom

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Birmingham, , United Kingdom

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Cardiff, , United Kingdom

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Coventry, , United Kingdom

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Dublin, , United Kingdom

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Dundee, , United Kingdom

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Glasgow, , United Kingdom

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Lancaster, , United Kingdom

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Leeds, , United Kingdom

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Leicester, , United Kingdom

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Liverpool, , United Kingdom

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London, , United Kingdom

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London, , United Kingdom

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London, , United Kingdom

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London, , United Kingdom

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Newcastle upon Tyne, , United Kingdom

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Newport, , United Kingdom

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Norwich, , United Kingdom

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Salford, , United Kingdom

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Sheffield, , United Kingdom

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Suffolk, , United Kingdom

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Countries

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Austria Belgium Czechia Denmark Finland France Germany Greece Hungary Italy Netherlands Norway Poland Portugal Spain Sweden Switzerland Turkey (Türkiye) United Kingdom

References

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Griffiths CE, Christophers E, Szumski A, Jones H, Mallbris L. Impact of early vs. late disease onset on treatment response to etanercept in patients with psoriasis. Br J Dermatol. 2015 Nov;173(5):1271-3. doi: 10.1111/bjd.13865. Epub 2015 Aug 17. No abstract available.

Reference Type DERIVED
PMID: 25913550 (View on PubMed)

Griffiths CE, Luger TA, Brault Y, Germain JM, Mallbris L. Retreatment in patients with psoriasis achieving response with etanercept after relapse due to treatment interruption: results from the CRYSTEL study. J Eur Acad Dermatol Venereol. 2015 Mar;29(3):468-73. doi: 10.1111/jdv.12585. Epub 2014 Aug 4.

Reference Type DERIVED
PMID: 25087839 (View on PubMed)

Other Identifiers

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0881A6-101764

Identifier Type: -

Identifier Source: org_study_id

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