Study to Describe the Allergic Reactions to Factor IX in Patients With Hemophilia B

NCT ID: NCT00195221

Last Updated: 2007-12-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

166 participants

Study Classification

OBSERVATIONAL

Study Start Date

2005-02-28

Study Completion Date

2007-11-30

Brief Summary

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Retrospective, multicenter study in patients with hemophilia B. This study will be placed at 20 to 50 hemophilia treatment centers in North America and the EU, and is designed to estimate the frequency of Class II and III allergic reactions in association with the administration of any FIX concentrate.

Following informed consent and eligibility, historical patient information including demographics, allergy history, hemophilia history, frequency and severity of allergic reaction(s), number of exposure days with products causing allergic reactions, exposure days to blood products including FIX concentrates, treatment for allergic reaction(s), outcome of event(s), any other adverse event(s) occuring within 48 hours of onset of allergic reaction(s), rechallenge and outcome, switch to another FIX product (if applicable) and outcome, current status of patient, and results of any special studies (eg, skin or RAST testing, alloantibody analyses, ect) will be collected.

Detailed Description

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Conditions

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Hemophilia B Allergic Reactions

Keywords

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Hemophilia B

Study Design

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Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Written consent to release patient information
* Living or deceased patients with mild to severe hemophilia B who have had at least 1 exposure to replacement factor IX product(s).
* Living or deceased patients who had their first infusion of any FIX product between 1 January 1991 and 31 December 2003.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Wyeth is now a wholly owned subsidiary of Pfizer

INDUSTRY

Sponsor Role lead

Principal Investigators

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Medical Monitor

Role: STUDY_DIRECTOR

Wyeth is now a wholly owned subsidiary of Pfizer

Trial Manager

Role: PRINCIPAL_INVESTIGATOR

For Germany, [email protected]

Trial Manager

Role: PRINCIPAL_INVESTIGATOR

For Austria, [email protected]

Trial Manager

Role: PRINCIPAL_INVESTIGATOR

For UK, [email protected]

Trial Manager

Role: PRINCIPAL_INVESTIGATOR

For Italy, [email protected]

Locations

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Phoenix, Arizona, United States

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Orange, California, United States

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Atlanta, Georgia, United States

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Boise, Idaho, United States

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Peoria, Illinois, United States

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Iowa City, Iowa, United States

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East Lansing, Michigan, United States

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Rochester, Minnesota, United States

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New Brunswick, New Jersey, United States

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Dayton, Ohio, United States

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Philadelphia, Pennsylvania, United States

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Memphis, Tennessee, United States

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Fort Worth, Texas, United States

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San Antonio, Texas, United States

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Seattle, Washington, United States

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Vienna, , Austria

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Brussels, , Belgium

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Montegnée, , Belgium

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Calgary, Alberta, Canada

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Liffré, , France

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Montmorency, , France

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Paris, , France

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Strasbourg, , France

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Hamburg, , Germany

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Münster, , Germany

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Catania, , Italy

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Catanzaro, , Italy

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Milan, , Italy

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Naples, , Italy

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Padua, , Italy

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Palermo, , Italy

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Parma, , Italy

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Perugia, , Italy

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Vicenza, , Italy

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Valencia, , Spain

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Valladolid, , Spain

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Wolverhampton, Wstmid, United Kingdom

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Cardiff, , United Kingdom

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Countries

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United States Austria Belgium Canada France Germany Italy Spain United Kingdom

Other Identifiers

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3090A-101657

Identifier Type: -

Identifier Source: org_study_id