Phase 2 Study of Atorvastatin Safety and Antitumor Effects in Non-Hodgkin's Lymphoma

NCT ID: NCT00185731

Last Updated: 2017-12-02

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 25 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2005-04-30
• Study Completion Date: 2012-11-30

Brief Summary

This is an approach which can inflict significant toxicity. An alternative is to block expression of oncogenes which are over-expressed only in cancer cells, a therapeutic approach which could reduce toxicity to the host while maximizing destruction of the oncogene-dependent malignant cells.

Detailed Description

Atorvastatin has been shown to decrease levels of active oncogenes in preclinical studies with murine and human lymphoma cell lines, and administration of statins leads to shrinkage of lymphoma in murine models. Therefore, it may be possible for atorvastatin to decrease levels of active oncogenes in human lymphomas. Further, upon decrease in levels of active oncogenes, human lymphomas may regress. Atorvastatin is a commonly prescribed drug for hypercholesterolemia: targeting the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase enzyme may also be a way to decrease activation of oncogenes in human lymphoma, with minimal toxicity. For human low grade non-Hodgkin lymphoma, no curative treatment is available; therefore new, non-toxic and targeted therapies are sought for this disease.

Conditions

Leukemia; Lymphoma, Non-Hodgkin

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

80 mg Atorvastatin

Atorvastatin, 80 mg tablet, will be taken orally by the patient daily, beginning on study day 1.

Group Type: EXPERIMENTAL

Atorvastatin

Intervention Type: DRUG

80 mg orally once daily

Interventions

Atorvastatin

80 mg orally once daily

Intervention Type: DRUG

Other Intervention Names

Lipitor

Eligibility Criteria

Inclusion Criteria

• > 18 years old
• Disease criteria: Confirmed by Stanford Pathology to be one of the following Non-Hodgkin's Lymphoma (NHL) subtypes:

• Chronic lymphocytic leukemia /small lymphocytic lymphoma (CLL/SLL)
• Extranodal marginal zone B-cell lymphoma
• Nodal marginal zone B-cell lymphoma
• Splenic marginal zone B-cell lymphoma
• Treatment criteria

• Untreated: watchful waiting currently appropriate (includes CLL stage 0) o OR
• Prior treatment: watchful waiting currently appropriate o OR
• Refractory disease
• Staging within 4 weeks prior to enrollment (SLL, marginal zone lymphoma)

• CT chest (date)
• CT abdomen (date)
• CT pelvis (date) OR
• Staging within 4 weeks prior to enrollment (CLL: CT not required)

• Total white blood cell count (WBC) (Value) (date)
• Absolute lymphoma cell count (ALC) (Value) (date)
• Measurable disease (Site) (Size) OR
• CLL (only): elevated absolute lymphoma cell count
• Disease amenable to biopsy (must check at least one):

• Circulating tumor cells
• Positive bone marrow
• Palpable involved site (such as lymph node) measuring > 1.5 cm
• Eastern Cooperative Oncology Group performance status <2 (Karnofsky >60)
• Life expectancy of greater than 3 months
• Patients must have adequate organ and marrow function

• Absolute neutrophil count > 1,000/uL
• Platelets > 30,000/uL
• Total bilirubin within normal institutional limits
• Aspartate aminotransferase (AST) / alanine aminotransferase (ALT) ratio < 2.5 x institutional upper limit of normal
• Creatinine within normal institutional limits OR creatinine clearance > 60 mL/min/1.73 m² for patients with creatinine levels above institutional normal.
• Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation. Women of child-bearing potential must have negative BetaHCG at enrollment

Exclusion Criteria

• Chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study
• Not recovered from adverse events due to agents administered more than four weeks earlier
• Has stable low grade lymphoma has had rituximab within 3 months Patient with relapsed or refractory disease has had rituximab within 1 month
• Not recovered from adverse events due to surgery performed 4 weeks earlier
• Receiving any other investigational agent. Known brain metastases
• Taken any statin within the past 6 months prior to enrollment in the trial
• Currently abuses alcohol
• Currently takes cyclosporin or gemfibrozil Patient has a prior history of rhabdomyolysis
• Has uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
• Pregnant: Patients are not excluded if they are breastfeeding at the time of enrollment, but breastfeeding should be discontinued if the mother is treated with atorvastatin.
• HIV-positive patients receiving combination anti-retroviral therapy

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

The Leukemia and Lymphoma Society

OTHER

Sponsor Role: collaborator

Damon Runyon Cancer Research Foundation

OTHER

Sponsor Role: collaborator

Burroughs Wellcome

INDUSTRY

Sponsor Role: collaborator

Dean Felsher

OTHER

Sponsor Role: lead

Responsible Party

Dean Felsher

Associate Professor

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Dean Felsher

Role: PRINCIPAL_INVESTIGATOR

Stanford University

Locations

Stanford University School of Medicine

Stanford, California, United States

Countries

United States

Other Identifiers

4328-07

Identifier Type: OTHER

Identifier Source: secondary_id

95140

Identifier Type: OTHER

Identifier Source: secondary_id

LYMNHL0020

Identifier Type: OTHER

Identifier Source: secondary_id

IRB-13683

Identifier Type: -

Identifier Source: org_study_id