Phase II Study of Celecoxib and Concurrent Radiotherapy in Stage II-III NSCLC

NCT ID: NCT00181532

Last Updated: 2009-06-30

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 102 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2003-05-31
• Study Completion Date: 2008-01-31

Brief Summary

The purpose of this study is to investigate the effect of the adminstration of celecoxib, a cox2-inhibitor in patients with stage II-III non small cell lung cancer receiving radical radiotherapy.

The hypothesis is that celecoxib will increase the remission rate of radiotherapy.

Detailed Description

Treatment of non-small cell lung cancer (NSCLC) is difficult, even with the best classical radiation and chemotherapy schedule results remain disappointing. However, there is evidence that increasing the local control rate by delivering radiotherapy either in a short period of time or concomitantly with chemotherapy improves survival. Drawback of a higher radiation dose or addition of chemotherapy is a higher incidence of toxicity. So radiation dose escalation could lead to further improvements of prognosis, but the radiation dose is however limited by radiation-induced lung and esophageal damage.

For NSCLC, non-toxic agents who both increase the effectiveness of radiotherapy and decrease radiation induced lung and esophageal damage are needed. The cox-2-inhibitors seem to be suitable for this purpose. In experimental mice tumor models, it was already shown that COX-2-inhibitors both inhibit tumor growth and enhance the radio-response of the tumor. Moreover, anti-inflammatory agents, such asCOX-2-inhibitors, also lowered the incidence of radiation pneumonitis and esophagitis.

In this study the simultaneous favourable effects of COX-2 inhibitors on tumor response and radiation damage in human cancer patients will be investigated.

Patients will be randomised to receive Celecoxib or placebo. All patients will receive the same radiotherapy treatment. Primary outcome measure is tumor response, assessed by a CT-scan of the thorax, three months after radiotherapy.

The tumor response rate of the experimental group will be compared to the tumor response rate of the control group.

Conditions

Non Small Cell Lung Carcinoma

Keywords

NSCLC; cox-2-inhibitor; radiosensitizer; radiotherapy

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Interventions

Celecoxib

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• histologically proven non-small cell lung cancer
• UICC stage II-III
• WHO performance status 0-2
• less than 10% weight loss the last 6 month
• in case of previous chemotherapy, radiotherapy may start after a minimum of 21 days after the last chemotherapy course
• reasonable lung function: FEV1>30% of the predicted value
• no recent(<3month) severe cardiac disease
• no active peptic ulcer disease
• normal serum bilirubin
• normal serum creatinin
• life expectancy more than 6 month
• measurable cancer
• willing and able to comply with the study prescriptions
• able to give written informed consent before patient registration/randomisation
• no previous radiotherapy to the chest

Exclusion Criteria

• not not small cell histology, e.g. mesothelioma, lymphoma
• mixed pathology, e.g. non small cell plus small cell cancer
• malignant pleural or pericardial effusion
• concurrent chemotherapy with radiation
• recent (<3month) myocardial infarction
• uncontrolled infectious disease
• distant metastases (stage IV)
• patients with active peptic ulceration or gastrointestinal bleeding in the last year
• patients with a past history of adverse reaction to NSAIDs
• renal disease
• chronic use of NSAIDs, COX-2 inhibitors or Aspirin in dosis >120mg/day.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Pfizer

INDUSTRY

Sponsor Role: collaborator

Maastricht Radiation Oncology

OTHER

Sponsor Role: lead

Principal Investigators

Dirk De Ruysscher, PHD

Role: PRINCIPAL_INVESTIGATOR

Maastricht Radiation Oncology (MAASTRO-clinic)

Locations

Maastircht Radiation Oncology

Heerlen, Limburg, Netherlands

Countries

Netherlands

Other Identifiers

CKTO 2003-07

Identifier Type: -

Identifier Source: secondary_id

IKL 2003-02

Identifier Type: -

Identifier Source: secondary_id

MEC MAASTRO 0205

Identifier Type: -

Identifier Source: secondary_id

P02.1376L

Identifier Type: -

Identifier Source: org_study_id