Trial Outcomes & Findings for Chest Wall Oscillation for Asthma and COPD Exacerbations Trial (COAT) (NCT NCT00181285)

Results Overview

Patient adherence to therapy after four treatments.

Recruitment status

COMPLETED

Study phase

NA

Target enrollment

52 participants

Primary outcome timeframe

After four treatments of 15 minutes each

Results posted on

2018-08-08

Participant Flow

Participant milestones

Participant milestones
Measure	Sham High Frequency Chest Wall Oscillation Sham high frequency chest wall oscillation. High Frequency Chest Wall Oscillator: High velocity, low amplitude oscillatory airflow applied through a pneumatic vest worn over the thorax	Active High Frequency Chest Wall Oscillation High frequency chest wall oscillation High Frequency Chest Wall Oscillator: High velocity, low amplitude oscillatory airflow applied through a pneumatic vest worn over the thorax
Overall Study STARTED	27	25
Overall Study COMPLETED	27	25
Overall Study NOT COMPLETED	0	0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Sex/Gender was not collected from any participant.

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Sham High Frequency Chest Wall Oscillation n=27 Participants Sham high frequency chest wall oscillation High Frequency Chest Wall Oscillator: High velocity, low amplitude oscillatory airflow applied through a pneumatic vest worn over the thorax	Active High Frequency Chest Wall Oscillation n=25 Participants High frequency chest wall oscillation High Frequency Chest Wall Oscillator: High velocity, low amplitude oscillatory airflow applied through a pneumatic vest worn over the thorax	Total n=52 Participants Total of all reporting groups
Age, Continuous	50.4 years n=27 Participants	46.5 years n=25 Participants	48.5 years n=52 Participants
Sex: Female, Male Female	—	—	0 Participants Sex/Gender was not collected from any participant.
Sex: Female, Male Male	—	—	0 Participants Sex/Gender was not collected from any participant.
Race and Ethnicity Not Collected	—	—	0 Participants Race and Ethnicity were not collected from any participant.

PRIMARY outcome

Timeframe: After four treatments of 15 minutes each

Patient adherence to therapy after four treatments.

Outcome measures

Outcome measures
Measure	Sham High Frequency Chest Wall Oscillation n=27 Participants Sham high frequency chest wall oscillation High Frequency Chest Wall Oscillator: High velocity, low amplitude oscillatory airflow applied through a pneumatic vest worn over the thorax	Active High Frequency Chest Wall Oscillation n=25 Participants Active high frequency chest wall oscillation High Frequency Chest Wall Oscillator: High velocity, low amplitude oscillatory airflow applied through a pneumatic vest worn over the thorax
Patient Adherence to High Frequency Chest Wall Oscillation	93 Percent of 60 minutes prescribed Standard Deviation 18.7	91 Percent of 60 minutes prescribed Standard Deviation 21.1

PRIMARY outcome

Timeframe: After four treatments of 15 minutes each

Population: 1 participant in the Sham group and 1 participant in the Active group had missing data for the question regarding the convenience of the pneumatic vest, therefore these participants were not included in the number analyzed for the outcome measure data table below.

The study vest was convenient to use.

Outcome measures

Outcome measures
Measure	Sham High Frequency Chest Wall Oscillation n=26 Participants Sham high frequency chest wall oscillation High Frequency Chest Wall Oscillator: High velocity, low amplitude oscillatory airflow applied through a pneumatic vest worn over the thorax	Active High Frequency Chest Wall Oscillation n=24 Participants Active high frequency chest wall oscillation High Frequency Chest Wall Oscillator: High velocity, low amplitude oscillatory airflow applied through a pneumatic vest worn over the thorax
Number of Participants Who Considered the Pneumatic Vest Convenient to Use	24 Participants	19 Participants

Adverse Events

Sham High Frequency Chest Wall Oscillation

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Active High Frequency Chest Wall Oscillation

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Jerry A. Krishnan

University of Illinois at Chicago

Phone: 312-413-0637

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place