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Congenital or Idiopathic Complete Right Bundle Branch Block: Physiological Significance and Molecular Characterization

NCT ID: NCT00173342

Last Updated: 2005-09-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2005-06-30

Brief Summary

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This study is to determine 1) the incidence of altered right bundle conduction, including CRBBB, IRBBB or rsR' pattern in the Taipei city based on the school survey databank from 1999 to 2002, 2) the associated cardiac lesions, 3) clinical presentations relevant to the altered right bundle conduction, 4) the association with QTc prolongation and dispersion and HRV from a 5-minutes recording. Finally, molecular characterization for those with CRBBB or Brugada pattern EKG, especially those with positive family history will be studied.

Detailed Description

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The EKG pattern and medical records from the school survey from 1999 to 2002 in Taipei city will be reviewed, and the basic data of those with CRBBB, IRBBB and rsR' pattern will be recorded. Interview will be made and the echocardiographic measurements will be performed to identify associated cardiac defects. EKG parameters and QT, QTc, QT dispersion, QTc dispersion and HRV parameters will be obtained from a semi-automated system. Time domain and frequency domain measures will be calculated and expressed as SDNN, triangular index, SDNN index, total power, low frequency power and high frequency power. Mutational analysis and DNA sequencing will be conducted in those with CRBBB or Brugada pattern EKG, especially those with positive family history.

Based on these data, the clinical significance of altered bundle branch conduction identified from a school survey may be defined. For those with isolated CRBBB or IRBBB, the adjunctive value of HRV and QT parameters will determined the high risk group, and 24 hour Holter recording and Treadmill exercise test will then perform in these patients to define association with ventricular arrhythmia.

Conditions

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Bundle-Branch Block

Keywords

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Right bundle branch block Electrocardiography Ion channel

Study Design

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Observational Model Type

DEFINED_POPULATION

Study Time Perspective

OTHER

Eligibility Criteria

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Inclusion Criteria

* ECG showed right bundle branch block

Exclusion Criteria

* can't tolerate Treadmill ECG study
Minimum Eligible Age

8 Years

Maximum Eligible Age

25 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Taiwan University Hospital

OTHER

Sponsor Role lead

Principal Investigators

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Mei-Hwan Wu, MD, PhD

Role: STUDY_CHAIR

National Taiwan University Hospital

Locations

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Department of Pediatrics, National Taiwan University Hospital

Taipei, , Taiwan

Site Status RECRUITING

Pediatric Department, National Taiwan University Hospital

Taipei, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Mei-Hwan Wu, MD, PhD

Role: CONTACT

Phone: 886-2-23123456

Email: [email protected]

Shuenn-Nan Chiu, MD

Role: CONTACT

Phone: 886-2-23123456

Email: [email protected]

Facility Contacts

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Mei-Hwan Wu, MD, PhD

Role: primary

Shuenn-Nan Chiu, MD

Role: backup

Shuenn-Nan Chiu, MD

Role: primary

Mei-Hwan Wu, MD, PhD

Role: backup

Other Identifiers

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9461700620

Identifier Type: -

Identifier Source: org_study_id