Environmental Enterovirus Monitoring

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2005-05-31

Study Completion Date

2005-06-30

Brief Summary

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From last decades, because of lacking the powerful quantitative methods, such as real-time qPCR, there is no environmental monitoring data about enterovirus transmission. If the major transmission routes and risk factor are still not clear, it will be very hard for making the prevention and control strategies. Today, the most popular prevention suggestion for children is keeping them away from crowded public places during the peak contagious season, because enteroviruses are easily transmitted through aerosols over a distance of meters, and even between separated rooms (Chang et al., 2004). However, adults may as easily be infected, but don』t have any disease symptoms or carry the virus home. Another recommendation is washing hands to avoid contact of hands or anything else with the mouth and nose, as it is through contact of viruses with the mucosal membranes in the mouth and nasal passages that infection occurs. However, these actions did not be great helpful for preventing enterovirus infection and spread. Understanding and disrupting the major transmission pass way of enterovirus could be more effective than just keeping personal hygiene. Therefore, an applicable environmental monitoring program is needed for understanding the transmission routes and risk factor of enterovirus infection. In this study, we will monitor enteroviruses in hospital, household and kindergarten. For the environmental monitoring of enteroviruses, we will apply traditional plaque assay, real-time quantitative PCR and combine with questionnaire-based interviews to understand the infectious types and concentration of enterovirus from indoor air, surface and water for recognizing the transmission routes of enterovirus and the relationships between virus concentration and the symptoms of the cases.

Detailed Description

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Environmental Monitoring Program for Enterovirus (1) Case Collection. The studies cases include patients who were suspected of having enterovirus illnesses, such as HFMD and herpangina. Institutional review board approval was obtained from the Hospital for this study and informed consent was obtained from all patients or their parents. (2) Questionnaire. questionnaire based interviews were used to collect information about the family members, including demographic data, the number of bedrooms in the house, amount of contact time with the patient, presence and pattern of current or recent signs and symptoms. (3) Patient and culture samples. Laboratory evidence of enterovirus infection was defined as the isolation of enterovirus from a throat , and rectal swab sample. (4) Environmental Sampling. (a) Air sampling. For the filter/real-time qPCR assay, the air in each ward was filtered through a 37-mm-diameter Nuclepore filter (Costar, Cambridge, MA), which is a track-etched polycarbonate filter consisting of a polycarbonate membrane with straight-through pores of uniform size (0.4 μm). The filters were supported by cellulose pads and loaded into open-face three-piece plastic cassettes. The pump and filter apparatus were placed within 1 m from the patient's bed on an adjacent nightstand. (b) Surface sampling Regarding surface sampling, surfaces of environment and equipment were sampled with moistened sterile cotton swabs.

Conditions

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Transmission Condition

Keywords

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enterovirus, environment, aerosol, air

Study Design

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Study Time Perspective

OTHER

Eligibility Criteria

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Inclusion Criteria

* any case of enterovirus infection

Exclusion Criteria

* not enterovirus infection cases

Minimum Eligible Age

1 Week

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Principal Investigators

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Luan-Yin Chang Chang, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

National Taiwan University Hospital

Locations

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National Taiwan University Hsopital

Taipei, Taipei, Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Luan-Yin Chang, MD

Role: CONTACT

Phone: 886-2-23123456

Email: [email protected]

Facility Contacts

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Luan-Yin Chang, MD, PhD

Role: primary

Other Identifiers

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9461700414

Identifier Type: -

Identifier Source: org_study_id